Oxidants -Antioxidant Status in Neonatal Jaundic With Severe G6PD Deficiency

ummary: Study of oxidative stress and some anti-oxidants with lipid peroxidation end product malondialdehyde in male neonatal jaundice with severe G6PD deficiency in Diwaniyah province of Iraq and the obtained results were compared with that found in control group. The mean ± SD of antioxidant status and oxidative stress parameters which include erythrocyte GSH, MDA, G-Red, G-Px and catalase were determined. There was a significant decrease in each of erythrocyte GSH, G-Red and catalase activity levels (P<0.05), whereas the lipid peroxidation end product MDA levels and G-Px activity levels were significantly increased in all neonatal jaundice (P < 0.05) as compared with the control group. G6PD activity values identified were found to be positively correlated with each of GSH concentrations, G-Red and catalase activity levels in which their values were found to decrease in patient groups, while it was found to be negatively correlated with each of G-Px activity and MDA levels in which their values were elevated in severe G6PD-deficient neonates. These data indicates an increases in free radical generation and thus antioxidant defense mechanisms is impaired in peroxidation associated with a significant elevation in MDA levels in the erythrocytes of neonatal jaundice with severe G6PD deficiency than that found in the control group which demonstrate the presence of an increased oxidative stress due to reduction in NADPH which is generated in RBCs by HMPshunt only.

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