Structural analysis of DNA oligomers in single crystals and in aqueous solutions by micro-FTIR and Raman spectroscopy

Being interested in the effects of base sequence and environmental conditions on the DNA structure, we have analyzed the solution and crystal structures of some G/C-rich DNA oligomers by vibrational spectroscopy. Here, we report on the analysis of the octamer d(GGGATCCC) and the decamer d(CCAGGCCTGG). Raman spectra were recorded on a Raman spectrometer as in, infrared spectra were measured with a Fourier transform infrared spectrophotometer Bruker IFS-66, for infrared measurements on crystals, the IFS-66 was coupled to an IR-microscope.