Discovery of New Antimalarial Compounds by use of Molecular Connectivity Techniques

Molecular connectivity has been applied to the search for new compounds with antimalarial activity. Linear discriminant analysis and connectivity functions were used to select several potentially suitable drugs which were tested for antimalarial properties by use of an in‐vitro micro test which estimates parasite growth by measurement of incorporation of [3H]hypoxanthine.

[1]  Ramón García-Domenech,et al.  Molecular connectivity to find β-blockers with low toxicity , 1997 .

[2]  Jorge Gálvez,et al.  Charge Indexes. New Topological Descriptors , 1994, J. Chem. Inf. Comput. Sci..

[3]  S. Unger.  Molecular Connectivity in Structure–activity Analysis , 1987 .

[4]  J. Gálvez,et al.  New cytostatic agents obtained by molecular topology , 1996 .

[5]  J. Gálvez,et al.  New bronchodilators selected by molecular topology. , 1998, Bioorganic & medicinal chemistry letters.

[6]  P. Brasseur,et al.  High level of sensitivity to chloroquine of 72 Plasmodium falciparum isolates from southern Cameroon in January 1985. , 1986, The American journal of tropical medicine and hygiene.

[7]  R. García-Domenech,et al.  Pharmacological Studies of 1‐(p‐Chlorophenyl)propanol and 2‐(1‐Hydroxy‐3‐butenyl)phenol: Two New Non‐narcotic Analgesics Designed by Molecular Connectivity , 1997, The Journal of pharmacy and pharmacology.

[8]  W. Dixon,et al.  BMDP statistical software , 1983 .

[9]  Ramón García-Domenech,et al.  Use of topological descriptiors in chromatographic chiral separations , 1996 .

[10]  J. Gálvez,et al.  New Analgesics Designed by Molecular Topology , 1996 .

[11]  Ramón García-Domenech,et al.  Topological approach to analgesia. , 1994, Journal of chemical information and computer sciences.

[12]  J. Gálvez,et al.  New antibacterial drugs designed by molecular connectivity , 1996 .

[13]  Jesús Vicente de Julián-Ortiz,et al.  Topological Approach to Drug Design , 1995, J. Chem. Inf. Comput. Sci..