A Novel Coronavirus from Patients with Pneumonia in China, 2019

Summary In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)

[1]  G. Gao,et al.  A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases — Wuhan, China 2019−2020 , 2020, China CDC weekly.

[2]  Marta Gwinn,et al.  Pathogen Genomics in Public Health. , 2019, The New England journal of medicine.

[3]  R. Lu,et al.  Viral and Bacterial Etiology of Acute Febrile Respiratory Syndrome among Patients in Qinghai, China , 2019, Biomedical and Environmental Sciences.

[4]  Zhènglì Shí,et al.  Origin and evolution of pathogenic coronaviruses , 2018, Nature Reviews Microbiology.

[5]  G. Gao,et al.  From “A”IV to “Z”IKV: Attacks from Emerging and Re-emerging Pathogens , 2018, Cell.

[6]  G. Gao,et al.  Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses , 2016, Trends in Microbiology.

[7]  R. Dijkman,et al.  Coronaviruses and the human airway: a universal system for virus-host interaction studies , 2016, Virology Journal.

[8]  Boping Zhou,et al.  MERS, SARS, and Ebola: The Role of Super-Spreaders in Infectious Disease , 2015, Cell Host & Microbe.

[9]  A. Osterhaus,et al.  Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. , 2012, The New England journal of medicine.

[10]  S. Weiss,et al.  Coronavirus Pathogenesis , 2011, Advances in Virus Research.

[11]  J. Simons,et al.  A new arenavirus in a cluster of fatal transplant-associated diseases. , 2008, The New England journal of medicine.

[12]  J. Peiris,et al.  Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003 , 2003, The Lancet.

[13]  Christian Drosten,et al.  Identification of a novel coronavirus in patients with severe acute respiratory syndrome. , 2003, The New England journal of medicine.

[14]  J. A. Comer,et al.  A novel coronavirus associated with severe acute respiratory syndrome. , 2003, The New England journal of medicine.