Applications of immobilized biocatalysts in chemical analysis

In 1974, Weetall published a report in Analytical Chemistry documenting the increasing interest in a relatively new concept in catalysis involving enzymes physically or covalently bound to a solid support. Very few reports of a new immobilization chemistry can stir enthusiasm, and the descriptions of new analysis systems have become less and less frequent. With these advances in mind, it seems appropriate to evaluate the use of immobilized enzymes as routine laboratory tools, a prediction made in 1976 (2), and the reasons for the success or failure of the technique. 20 references, 5 figures, 2 tables.

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