Temporal Classification of Medical Events

We investigate the task of assigning medical events in clinical narratives to discrete time-bins. The time-bins are defined to capture when a medical event occurs relative to the hospital admission date in each clinical narrative. We model the problem as a sequence tagging task using Conditional Random Fields. We extract a combination of lexical, section-based and temporal features from medical events in each clinical narrative. The sequence tagging system outperforms a system that does not utilize any sequence information modeled using a Maximum Entropy classifier. We present results with both hand-tagged as well as automatically extracted features. We observe over 8% improvement in overall tagging accuracy with the inclusion of sequence information.

[1]  James F. Allen An Interval-Based Representation of Temporal Knowledge , 1981, IJCAI.

[2]  George Hripcsak,et al.  Temporal reasoning with medical data - A review with emphasis on medical natural language processing , 2007, J. Biomed. Informatics.

[3]  Robert J. Gaizauskas,et al.  Task-Oriented Extraction of Temporal Information: The Case of Clinical Narratives , 2006, Thirteenth International Symposium on Temporal Representation and Reasoning (TIME'06).

[4]  Adam L. Berger,et al.  A Maximum Entropy Approach to Natural Language Processing , 1996, CL.

[5]  Andrew McCallum,et al.  Conditional Random Fields: Probabilistic Models for Segmenting and Labeling Sequence Data , 2001, ICML.

[6]  James Pustejovsky,et al.  The TempEval challenge: identifying temporal relations in text , 2009, Lang. Resour. Evaluation.

[7]  Wayne H. Ward,et al.  Towards Temporal Relation Discovery from the Clinical Narrative , 2009, AMIA.

[8]  A. J. Conger Integration and generalization of kappas for multiple raters. , 1980 .

[9]  James Pustejovsky,et al.  TimeML: Robust Specification of Event and Temporal Expressions in Text , 2003, New Directions in Question Answering.

[10]  Ying Li,et al.  Section classification in clinical notes using supervised hidden markov model , 2010, IHI.

[11]  George Hripcsak,et al.  A temporal constraint structure for extracting temporal information from clinical narrative , 2006, J. Biomed. Informatics.

[12]  Alan R. Aronson,et al.  Effective mapping of biomedical text to the UMLS Metathesaurus: the MetaMap program , 2001, AMIA.

[13]  Nate Blaylock,et al.  Building Timelines from Narrative Clinical Records: Initial Results Based-on Deep Natural Language Understanding , 2011, BioNLP@ACL.

[14]  Xiaoying Wu,et al.  EliXR: an approach to eligibility criteria extraction and representation , 2011, J. Am. Medical Informatics Assoc..