What effect does asthma treatment have on airway remodeling? Current perspectives.

[1]  M. Ostrovskyy,et al.  Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling , 2013 .

[2]  P. Howarth,et al.  Effect of bronchoconstriction on airway remodeling in asthma. , 2011, The New England journal of medicine.

[3]  Ching-Chi Lin,et al.  Effects of erlotinib on pulmonary function and airway remodeling after sensitization and repeated allergen challenge in Brown-Norway rats , 2011, Respiratory Physiology & Neurobiology.

[4]  Chan Kwon Park,et al.  Effect of Imatinib on Airway Smooth Muscle Thickening in a Murine Model of Chronic Asthma , 2011, International Archives of Allergy and Immunology.

[5]  E. Israel,et al.  Tiotropium bromide step-up therapy for adults with uncontrolled asthma. , 2010, The New England journal of medicine.

[6]  S. Staibano,et al.  Angiogenesis and lymphangiogenesis in bronchial asthma , 2010, Allergy.

[7]  K. Ohta,et al.  Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[8]  A. Bodzenta-Lukaszyk,et al.  Anti-IgE Therapy with Omalizumab Decreases Endothelin-1 in Exhaled Breath Condensate of Patients with Severe Persistent Allergic Asthma , 2010, Respiration.

[9]  P. O'Byrne,et al.  Recent advances in the pathophysiology of asthma. , 2010, Chest.

[10]  Q. Hamid,et al.  Airway remodeling in asthma. , 2010, Current opinion in pharmacology.

[11]  P. O'Byrne,et al.  Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma. , 2010, The Journal of allergy and clinical immunology.

[12]  Parameswaran Nair,et al.  Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. , 2009, The New England journal of medicine.

[13]  L. Bjermer,et al.  Montelukast in the treatment of asthma and beyond , 2009, Expert review of clinical immunology.

[14]  A. Miller-Larsson,et al.  Budesonide/formoterol effects on metalloproteolytic balance in TGFbeta-activated human lung fibroblasts. , 2009, Respiratory medicine.

[15]  D. McDonald,et al.  TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. , 2009, The Journal of clinical investigation.

[16]  I. Pavord,et al.  Airway inflammation in patients with asthma with high-fixed or low-fixed plus as-needed budesonide/formoterol. , 2009, The Journal of allergy and clinical immunology.

[17]  E. Kerwin,et al.  A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. , 2009, American journal of respiratory and critical care medicine.

[18]  Ana Sousa,et al.  Mepolizumab and exacerbations of refractory eosinophilic asthma. , 2009, The New England journal of medicine.

[19]  S. Royce,et al.  Effect of extracellular matrix composition on airway epithelial cell and fibroblast structure: implications for airway remodeling in asthma. , 2009, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[20]  L. Fabbri,et al.  Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma. , 2008, American journal of respiratory and critical care medicine.

[21]  D. Broide Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. , 2008, The Journal of allergy and clinical immunology.

[22]  P. J. Barnes,et al.  Global strategy for asthma management and prevention: GINA executive summary , 2008, European Respiratory Journal.

[23]  W. Busse,et al.  A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. , 2007, American journal of respiratory and critical care medicine.

[24]  P. Sterk,et al.  Asthma therapy and airway remodeling. , 2007, The Journal of allergy and clinical immunology.

[25]  A. Halayko,et al.  Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison , 2007, European Respiratory Journal.

[26]  D. Postma,et al.  Severe exacerbations predict excess lung function decline in asthma , 2007, European Respiratory Journal.

[27]  C. Seow,et al.  Structural basis for exaggerated airway narrowing. , 2007, Canadian journal of physiology and pharmacology.

[28]  P. Chanez,et al.  Specificity of basement membrane thickening in severe asthma. , 2007, The Journal of allergy and clinical immunology.

[29]  E. Walters,et al.  Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma , 2006, Thorax.

[30]  L. Fabbri,et al.  Epithelial damage and angiogenesis in the airways of children with asthma. , 2006, American journal of respiratory and critical care medicine.

[31]  Maree H. Poniris,et al.  A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro. , 2006, The Journal of allergy and clinical immunology.

[32]  I. Hall,et al.  Glucocorticoids Increase Repair Potential in a Novel in vitro Human Airway Epithelial Wounding Model , 2006, Journal of Clinical Immunology.

[33]  J. Fahy Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation. , 2006, The Journal of allergy and clinical immunology.

[34]  N. Ilhan,et al.  The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model , 2006, Experimental and Molecular Medicine.

[35]  E. Chi,et al.  Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade. , 2006, American journal of respiratory and critical care medicine.

[36]  I. Pavord,et al.  Evidence of a role of tumor necrosis factor alpha in refractory asthma. , 2006, The New England journal of medicine.

[37]  Q. Hamid,et al.  Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide. , 2005, The Journal of allergy and clinical immunology.

[38]  Yu‐Ching Huang,et al.  Effects of omalizumab and budesonide on markers of inflammation in human bronchial epithelial cells. , 2005, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[39]  K. Rabe,et al.  Bronchial matrix and inflammation respond to inhaled steroids despite ongoing allergen exposure in asthma , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[40]  C. Lemière,et al.  Differences in airway remodeling between subjects with severe and moderate asthma. , 2005, The Journal of allergy and clinical immunology.

[41]  A. James,et al.  Remodelling of airway smooth muscle in asthma: what sort do you have? , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[42]  K. Chung,et al.  Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features. , 2005, The Journal of allergy and clinical immunology.

[43]  T. Haahtela,et al.  Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. , 2005, American journal of respiratory and critical care medicine.

[44]  S. Orkin,et al.  A Critical Role for Eosinophils in Allergic Airways Remodeling , 2004, Science.

[45]  M. Bihl,et al.  Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. , 2004, The New England journal of medicine.

[46]  M. Hoshino Impact of inhaled corticosteroids and leukotriene receptor antagonists on airway remodeling , 2004, Clinical reviews in allergy & immunology.

[47]  A. Ionescu,et al.  Mucus hypersecretion: a common symptom, a common mechanism? , 2004, European Respiratory Journal.

[48]  Reynold A Panettieri,et al.  Is airway remodeling clinically relevant in asthma? , 2003, The American journal of medicine.

[49]  S. Phipps,et al.  Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. , 2003, The Journal of clinical investigation.

[50]  E. Gelfand,et al.  Histopathology of severe childhood asthma: a case series. , 2003, Chest.

[51]  P. Macklem,et al.  Airway wall remodeling: friend or foe? , 2003, Journal of applied physiology.

[52]  L. Boulet,et al.  Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. , 2003, The Journal of allergy and clinical immunology.

[53]  M. Aubier,et al.  Airway structural alterations selectively associated with severe asthma. , 2003, American journal of respiratory and critical care medicine.

[54]  R. D'Ippolito,et al.  Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. , 2003, American journal of respiratory and critical care medicine.

[55]  S. Holgate,et al.  Airway remodeling in asthma: new insights. , 2003, The Journal of allergy and clinical immunology.

[56]  D. Dorscheid,et al.  Corticosteroid-induced apoptosis of airway epithelium: a potential mechanism for chronic airway epithelial damage in asthma. , 2002, Chest.

[57]  M. Adachi,et al.  Structural changes of the airway wall impair respiratory function, even in mild asthma. , 2002, Chest.

[58]  R. Pauwels,et al.  Dose-related effect of inhaled fluticasone on allergen-induced airway changes in rats , 2002, European Respiratory Journal.

[59]  R. Pauwels,et al.  Fluticasone inhibits the progression of allergen‐induced structural airway changes , 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[60]  D. Johns,et al.  Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma , 2002, Thorax.

[61]  M. Adachi,et al.  Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma , 2002, Thorax.

[62]  M. Adachi,et al.  Reduction of eosinophilic inflammation in the airways of patients with asthma using montelukast. , 2002, Chest.

[63]  Steven Sun,et al.  Apoptosis of airway epithelial cells induced by corticosteroids. , 2001, American journal of respiratory and critical care medicine.

[64]  D. Johns,et al.  Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma. , 2001, American journal of respiratory and critical care medicine.

[65]  R. Pellegrino,et al.  On the functional consequences of bronchial basement membrane thickening. , 2001, Journal of applied physiology.

[66]  N. Aoike,et al.  Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthma , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[67]  R. Pauwels,et al.  Fluticasone inhibits but does not reverse allergen-induced structural airway changes. , 2001, American journal of respiratory and critical care medicine.

[68]  N. Zamel,et al.  Unsuspected pseudophysiologic emphysema in chronic persistent asthma. , 2000, American journal of respiratory and critical care medicine.

[69]  L. Boulet,et al.  Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of inhaled corticosteroids. , 2000, American journal of respiratory and critical care medicine.

[70]  W. Busse,et al.  Increased matrix metalloproteinase-9 in the airway after allergen challenge. , 2000, American journal of respiratory and critical care medicine.

[71]  S. Peters,et al.  Airway remodeling and persistent airway obstruction in asthma. , 1999, The Journal of allergy and clinical immunology.

[72]  M. Hoshino,et al.  Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma. , 1999, The Journal of allergy and clinical immunology.

[73]  P. Vadiveloo,et al.  Glucocorticoids inhibit proliferation, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle. , 1999, American journal of respiratory cell and molecular biology.

[74]  J. Vandenbroucke,et al.  Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. , 1999, American journal of respiratory and critical care medicine.

[75]  F. Thien,et al.  Vascularity in asthmatic airways: relation to inhaled steroid dose. , 1999, Thorax.

[76]  Hoshino,et al.  Inhaled corticosteroid reduced lamina reticularis of the basement membrane by modulation of insulin‐like growth factor (IGF)‐I expression in bronchial asthma , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[77]  I. Virtanen,et al.  Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. , 1997, American journal of respiratory and critical care medicine.

[78]  Third Expert Panel on theDiagnosis,et al.  Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma , 1997 .

[79]  A. Casalini,et al.  Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: a placebo-controlled study. , 1997, American journal of respiratory and critical care medicine.

[80]  M. Jordana,et al.  Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. , 1996, American journal of respiratory cell and molecular biology.

[81]  S. Wenzel,et al.  Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. , 1995, American journal of respiratory and critical care medicine.

[82]  F. Sundler,et al.  Effects of topical budesonide on epithelial restitution in vivo in guinea pig trachea. , 1995, Thorax.

[83]  M. Calderón,et al.  Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. , 1994, American journal of respiratory and critical care medicine.

[84]  R. Schellenberg,et al.  Hypothesis: excessive bronchoconstriction in asthma is due to decreased airway elastance. , 1994, The European respiratory journal.

[85]  P. Paré,et al.  Small airways dimensions in asthma and in chronic obstructive pulmonary disease. , 1993, The American review of respiratory disease.

[86]  M. Ebina,et al.  Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. , 1993, The American review of respiratory disease.

[87]  P. Jeffery,et al.  Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. , 1992, The American review of respiratory disease.

[88]  M. Ebina,et al.  Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. , 1992, Chest.

[89]  S. Holgate,et al.  SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS , 1989, The Lancet.

[90]  R. Stenling,et al.  Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids. , 1988, The European respiratory journal.

[91]  B. Weeke,et al.  Fiberoptic bronchoscopy and bronchial mucosal biopsies in asthmatics undergoing long‐term high‐dose budesonide aerosol treatment , 1988, Allergy.

[92]  A. Cats,et al.  HL-A 27 AND ANKYLOSING SPONDYLITIS , 1975, The Lancet.

[93]  B. Naylor The Shedding of the Mucosa of the Bronchial Tree in Asthma , 1962, Thorax.

[94]  Chun-Tao Liu,et al.  Effects of formoterol-budesonide on airway remodeling in patients with moderate asthma , 2011, Acta Pharmacologica Sinica.

[95]  J. Castro‐Rodriguez,et al.  Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: a systematic review. , 2011, Chest.

[96]  William W Busse,et al.  Severe exacerbations and decline in lung function in asthma. , 2009, American journal of respiratory and critical care medicine.

[97]  C. Brightling,et al.  Targeting TNF-α: A novel therapeutic approach for asthma , 2008 .

[98]  Q. Hamid,et al.  Airway remodeling in asthma. , 2007, Allergology international : official journal of the Japanese Society of Allergology.

[99]  A. Bush,et al.  Early thickening of the reticular basement membrane in children with difficult asthma. , 2003, American journal of respiratory and critical care medicine.

[100]  T. Koelmeyer,et al.  The effect of age and duration of disease on airway structure in fatal asthma. , 2000, American journal of respiratory and critical care medicine.