Optimal design of automatic control system for the fed-batch production of 1,3-propanediol with pH logic control

In this work, the fed-batch fermentation of glycerol by Klebsiella pneumoniae with pH logic control is discussed. We propose a hybrid system constrained optimal control problem with glycerol feeding instants as control variables to maximize the concentration of the objective product at the terminal time. Correspondingly, we explore an automatic control system to implement the optimal control strategy, in which the designs of control diagram, PLC control and supervisory computer control system are involved. This work achieves a goal of applying numerical optimal control analysis to the design of control system in glycerol fed-batch fermentation.

[1]  M. Sauer,et al.  Microbial production of 1,3-propanediol. , 2008, Recent patents on biotechnology.

[2]  Enmin Feng,et al.  Vector measure as controls for explicit nonlinear impulsive system of fed-batch culture , 2009 .

[3]  An Li,et al.  Mathematical modeling of kinetics and research on multiplicity of glycerol bioconversion to 1,3-propanediol , 2000 .

[4]  Lei Wang.  Modelling and Regularity of Nonlinear Impulsive Switching Dynamical System in Fed-Batch Culture , 2012 .

[5]  Shan Jiang,et al.  Automatic Control Design for Optimal Strategy in Fed-batch Culture with Coupled Feed of Glycerol and Alkali , 2010 .

[6]  A. Zeng,et al.  High concentration and productivity of 1,3-propanediol from continuous fermentation of glycerol by Klebsiella pneumoniae , 1997 .

[7]  W. Jian-feng.  Determination of glycerin concentration during the fermentation of glycerin to 1,3-propanediol , 2001 .

[8]  Zong-ming Zheng,et al.  3-Hydroxypropionaldehyde guided glycerol feeding strategy in aerobic 1,3-propanediol production by Klebsiella pneumoniae , 2008, Journal of Industrial Microbiology & Biotechnology.

[9]  Lei Wang,et al.  Determining the transport mechanism of an enzyme-catalytic complex metabolic network based on biological robustness , 2013, Bioprocess and Biosystems Engineering.

[10]  Enmin Feng,et al.  Modelling and well-posedness of a nonlinear hybrid system in fed-batch production of 1,3-propanediol with open loop glycerol input and pH logic control , 2011 .

[11]  E. Feng,et al.  MODELLING AND OPTIMAL CONTROL FOR NONLINEAR MULTISTAGE DYNAMICAL SYSTEM OF MICROBIAL FED-BATCH CULTURE , 2009 .

[12]  Z. Xiu,et al.  V4-Y-046Dynamic behavior of glycerol–glucose co-fermentation for 1,3-propanediol production by Klebsiella pneumoniae under micro-aerobic conditions , 2008 .

[13]  E. Feng,et al.  μ-Synthesis of dissimilation process of glycerol to 1,3-propanediol in microbial continuous culture , 2014, World journal of microbiology & biotechnology.

[14]  Enmin Feng,et al.  Modelling and pathway identification involving the transport mechanism of a complex metabolic system in batch culture , 2014, Commun. Nonlinear Sci. Numer. Simul..

[15]  Shan-Jing Yao,et al.  Microbial production of 1,3-propanediol from glycerol by encapsulated Klebsiella pneumoniae , 2006 .

[16]  Yan Sun,et al.  Pilot-scale production of 1,3-propanediol using Klebsiella pneumoniae , 2007 .