5-HT 3 Receptors

The 5-HT3receptor directly gates an ion-channel. This makes it unique among the receptors for 5-HT. This unique nature is reflected in some of the characteristics of this receptor. In this review we give an overview of the characteristics of the 5-HT3receptor focusing on the more interesting features.

[1]  R. Myers,et al.  Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. , 1991, Science.

[2]  R. North,et al.  5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala , 1992, Neuron.

[3]  K. Bunce,et al.  Clinical evaluation of 5-HT3 receptor antagonists as anti-emetics. , 1991, Trends in pharmacological sciences.

[4]  G. Engel,et al.  Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs , 1985, Nature.

[5]  Gavin Kilpatrick,et al.  Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species. , 1989, European journal of pharmacology.

[6]  N. Ropert,et al.  Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro. , 1991, The Journal of physiology.

[7]  J. Leeser,et al.  Prevention of Postoperative Nausea and Vomiting Using Ondansetron, a New, Selective, 5‐HT3 Receptor Antagonist , 1991, Anesthesia and analgesia.

[8]  Gavin Kilpatrick,et al.  The pharmacological characterization of 5‐HT3 receptors in three isolated preparations derived from guinea‐pig tissues , 1990, British journal of pharmacology.

[9]  N. Newberry,et al.  Evidence that the 5‐HT3 receptors of the rat, mouse and guinea‐pig superior cervical ganglion may be different , 1991, British journal of pharmacology.

[10]  C. Ashby,et al.  Characterization of 5-hydroxytryptamine3 receptors in the medial prefrontal cortex: a microiontophoretic study. , 1989, European journal of pharmacology.

[11]  J. A. Peters,et al.  Physiological and pharmacological properties of 5-HT3 receptors — A patch clamp-study , 1991, Neuropeptides.

[12]  R. North,et al.  5-HT3 receptors are membrane ion channels , 1989, Nature.

[13]  B. Costall,et al.  The psychopharmacology of 5-HT3 receptors. , 1990, Pharmacology & therapeutics.

[14]  J. A. Peters,et al.  Electrophysiology of 5-HT3 receptors in neuronal cell lines. , 1989, Trends in pharmacological sciences.

[15]  M B Jackson,et al.  Three serotonin responses in cultured mouse hippocampal and striatal neurons , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[16]  B. Costall,et al.  Agonist interactions with 5‐HT3 receptor recognition sites in the rat entorhinal cortex labelled by structurally diverse radioligands , 1992, British journal of pharmacology.

[17]  Gavin Kilpatrick,et al.  5‐HT3 receptors , 1990, Annals of the New York Academy of Sciences.

[18]  A Butler,et al.  1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. , 1990, European journal of pharmacology.

[19]  G. Higgins,et al.  5‐HT3 receptor antagonists injected into the area postrema inhibit cisplatin‐induced emesis in the ferret , 1989, British journal of pharmacology.

[20]  J. Fozard Differences between receptors for 5-hydroxytryptamine on autonomic neurones revealed by nor-(-)-cocaine. , 1983, Journal of autonomic pharmacology.

[21]  B. Costall,et al.  The pharmacological characterization of 5-HT3 receptor binding sites in rabbit ileum: Comparison with those in rat ileum and rat brain , 1991, Neurochemistry International.

[22]  Gavin Kilpatrick,et al.  Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding , 1987, Nature.