A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity

[1]  Bum-Tae Kim,et al.  Structure-Based Virtual Screening: Identification of a Novel NS2B-NS3 Protease Inhibitor with Potent Antiviral Activity against Zika and Dengue Viruses , 2021, Microorganisms.

[2]  Duncan R. Smith,et al.  Analysis of the virus propagation profile of 14 dengue virus isolates in Aedes albopictus C6/36 cells , 2020, BMC research notes.

[3]  J. Smit,et al.  Recent advances in antiviral drug development towards dengue virus. , 2020, Current opinion in virology.

[4]  Jessica L. Cohen,et al.  Development of a potent Zika virus vaccine using self-amplifying messenger RNA , 2020, Science Advances.

[5]  H. Harapan,et al.  Dengue: A Minireview , 2020, Viruses.

[6]  Yong Wei,et al.  A Review on Dengue Vaccine Development , 2020, Vaccines.

[7]  A. Debnath,et al.  Identification of Novel Natural Products as Effective and Broad-Spectrum Anti-Zika Virus Inhibitors , 2019, Viruses.

[8]  Lu Lu,et al.  A Peptide-Based Virus Inactivator Protects Male Mice Against Zika Virus-Induced Damage of Testicular Tissue , 2019, Front. Microbiol..

[9]  S. Vasudevan,et al.  Assessing the utility of antivirals for preventing maternal-fetal transmission of zika virus in pregnant mice. , 2019, Antiviral research.

[10]  Fang Li,et al.  Rational Design of Zika Virus Subunit Vaccine with Enhanced Efficacy , 2019, Journal of Virology.

[11]  S. Khurana,et al.  Differential human antibody repertoires following Zika infection and the implications for serodiagnostics and disease outcome , 2019, Nature Communications.

[12]  L. Du,et al.  Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding Domain , 2019, Viruses.

[13]  D. Kessler,et al.  Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise , 2019, Front. Microbiol..

[14]  Rajanish Giri,et al.  Hydroxychloroquine Inhibits Zika Virus NS2B-NS3 Protease , 2018, ACS omega.

[15]  R. Schooley,et al.  Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice. , 2018, Cell host & microbe.

[16]  K. Meng,et al.  Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes , 2018, Science Advances.

[17]  J. Hardy,et al.  The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins. , 2018, ACS chemical biology.

[18]  Jenifer B. Kaplan,et al.  Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. , 2018, Cell chemical biology.

[19]  N. Gray,et al.  Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein. , 2018, ACS infectious diseases.

[20]  H. Hotta,et al.  Time-of-addition and Temperature-shift Assays to Determine Particular Step(s) in the Viral Life Cycle that is Blocked by Antiviral Substance(s). , 2018, Bio-protocol.

[21]  H. Rothan,et al.  Current concerns and perspectives on Zika virus co-infection with arboviruses and HIV. , 2018, Journal of autoimmunity.

[22]  L. Kramer,et al.  Erythrosin B is a potent and broad‐spectrum orthosteric inhibitor of the flavivirus NS2B‐NS3 protease , 2018, Antiviral research.

[23]  A. Saghatelian,et al.  Blocking Zika virus vertical transmission , 2018, Scientific Reports.

[24]  J. Pasto,et al.  Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation , 2018, Journal of Virology.

[25]  J. Mascola,et al.  Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials , 2017, The Lancet.

[26]  Alison E Kosel,et al.  Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials , 2017, The Lancet.

[27]  D. Fremont,et al.  Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses , 2018, Emerging Microbes & Infections.

[28]  T. Noda,et al.  Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane , 2017, Scientific Reports.

[29]  P. Shi,et al.  A single mutation in the prM protein of Zika virus contributes to fetal microcephaly , 2017, Science.

[30]  T. Keller,et al.  Zika Virus Protease: An Antiviral Drug Target. , 2017, Trends in microbiology.

[31]  A. Nath,et al.  Therapeutic Approaches for Zika Virus Infection of the Nervous System , 2017, Neurotherapeutics.

[32]  Zheng Zhu,et al.  Structure‐based discovery of clinically approved drugs as Zika virus NS2B‐NS3 protease inhibitors that potently inhibit Zika virus infection in vitro and in vivo , 2017, Antiviral research.

[33]  Qisheng Zhang,et al.  High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain. , 2017, Cell stem cell.

[34]  K. Yuen,et al.  A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses , 2017, Nature Communications.

[35]  E. Zeng,et al.  Global Epidemiology of Dengue Outbreaks in 1990–2015: A Systematic Review and Meta-Analysis , 2017, Front. Cell. Infect. Microbiol..

[36]  Susan A. Jones,et al.  Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction , 2017, Cell Research.

[37]  A. Strongin,et al.  Characterization of the Zika virus two‐component NS2B‐NS3 protease and structure‐assisted identification of allosteric small‐molecule antagonists , 2017, Antiviral research.

[38]  B. Guy,et al.  A recombinant live attenuated tetravalent vaccine for the prevention of dengue , 2017, Expert review of vaccines.

[39]  C. Rice,et al.  Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico , 2017, Cell.

[40]  C. Yip,et al.  Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B‐NS3 protease inhibitor , 2017, Antiviral research.

[41]  Ping Liu,et al.  25‐Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model , 2017, Immunity.

[42]  R. DeBiasi,et al.  Zika Virus Infection With Prolonged Maternal Viremia and Fetal Brain Abnormalities , 2017 .

[43]  Jennifer E. Golden,et al.  Evaluation of anti‐Zika virus activities of broad‐spectrum antivirals and NIH clinical collection compounds using a cell‐based, high‐throughput screen assay , 2017, Antiviral research.

[44]  W. Sheridan,et al.  Efficacy of the broad‐spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model , 2017, Antiviral research.

[45]  James E. Crowe,et al.  Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice , 2016, Nature.

[46]  G. Gao,et al.  Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice , 2016, Cell.

[47]  S. Perlman,et al.  Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines , 2016, Nature Communications.

[48]  B. Giordano,et al.  Zika Virus: Quantification, Propagation, Detection, and Storage. , 2016, Current protocols in microbiology.

[49]  Justin M. Richner,et al.  Zika virus infection damages the testes in mice , 2016, Nature.

[50]  D. Page,et al.  Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice , 2016, Scientific Reports.

[51]  Zuguang Wang,et al.  Infection of human uterine fibroblasts by Zika virus in vitro: implications for viral transmission in women. , 2016, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[52]  Ruili Huang,et al.  Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen , 2016, Nature Medicine.

[53]  P. Zanotto,et al.  Prolonged Shedding of Zika Virus Associated with Congenital Infection. , 2016, The New England journal of medicine.

[54]  M. Beltramello,et al.  Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection , 2016, Science.

[55]  C. Nelson,et al.  Structural Basis of Zika Virus-Specific Antibody Protection , 2016, Cell.

[56]  Nikos Vasilakis,et al.  A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection. , 2016, Cell host & microbe.

[57]  Christoph Nitsche,et al.  Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor , 2016, Science.

[58]  Zhiheng Xu,et al.  Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. , 2016, Cell stem cell.

[59]  Carlos G Schrago,et al.  Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. , 2016, The Lancet. Infectious diseases.

[60]  R. Tesh,et al.  Characterization of a Novel Murine Model to Study Zika Virus , 2016, The American journal of tropical medicine and hygiene.

[61]  M. Diamond,et al.  Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise , 2016, Cell.

[62]  W. Cao,et al.  Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice , 2016, Cell Research.

[63]  Amadou A. Sall,et al.  The Brazilian Zika virus strain causes birth defects in experimental models , 2016, Nature.

[64]  J. An,et al.  Zika virus and Zika fever , 2016, Virologica Sinica.

[65]  Giovanini Evelim Coelho,et al.  Zika virus in the Americas: Early epidemiological and genetic findings , 2016, Science.

[66]  S. Rasmussen,et al.  Zika Virus and Birth Defects--Reviewing the Evidence for Causality. , 2016, The New England journal of medicine.

[67]  D. Butler.  First Zika-linked birth defects detected in Colombia , 2016, Nature.

[68]  M. Diamond,et al.  Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere , 2016, Journal of Virology.

[69]  A. Act,et al.  Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report. , 2016 .

[70]  C. Yip,et al.  Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease , 2016, Journal of Infection.

[71]  J. Neyts,et al.  The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model , 2016, bioRxiv.

[72]  R. Lanciotti,et al.  Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses--Brazil, 2015. , 2016, MMWR. Morbidity and mortality weekly report.

[73]  Marko Kolenc,et al.  Zika Virus Associated with Microcephaly. , 2016, The New England journal of medicine.

[74]  A. Ko,et al.  Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise , 2016, PLoS neglected tropical diseases.

[75]  G. Malinger,et al.  Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? , 2016, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[76]  L. R. Petersen,et al.  Zika Virus. , 2016, The New England journal of medicine.

[77]  Andrew Curry,et al.  ßΣΤΛ testing. , 2021, Diabetes forecast.

[78]  A. Barrett,et al.  Mouse models of dengue virus infection for vaccine testing. , 2015, Vaccine.

[79]  A. Barrett,et al.  Characterization of lethal dengue virus type 4 (DENV-4) TVP-376 infection in mice lacking both IFN-α/β and IFN-γ receptors (AG129) and comparison with the DENV-2 AG129 mouse model. , 2015, The Journal of general virology.

[80]  Yufei Wang,et al.  Discovery of pentacyclic triterpenoids as potential entry inhibitors of influenza viruses. , 2014, Journal of medicinal chemistry.

[81]  M. M. Melo,et al.  Gossypol Toxicity from Cottonseed Products , 2014, TheScientificWorldJournal.

[82]  M. Besnard,et al.  Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. , 2014, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[83]  A. Barrett,et al.  A Lethal Murine Infection Model for Dengue Virus 3 in AG129 Mice Deficient in Type I and II Interferon Receptors Leads to Systemic Disease , 2014, Journal of Virology.

[84]  A. Amara,et al.  Flavivirus Entry Receptors: An Update , 2013, Viruses.

[85]  A. K. Rathinam,et al.  Inhibition of Dengue Virus Entry into Target Cells Using Synthetic Antiviral Peptides , 2013, International journal of medical sciences.

[86]  John S. Brownstein,et al.  The global distribution and burden of dengue , 2013, Nature.

[87]  F. Lang,et al.  Gossypol-induced suicidal erythrocyte death. , 2012, Toxicology.

[88]  Hong Lu,et al.  A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains , 2012, Retrovirology.

[89]  Lei Shi,et al.  Rapid identification of Chikungunya and Dengue virus by a real-time reverse transcription-loop-mediated isothermal amplification method. , 2012, The American journal of tropical medicine and hygiene.

[90]  R. Ray,et al.  Identification of a Small-Molecule Entry Inhibitor for Filoviruses , 2011, Journal of Virology.

[91]  R. Lanciotti,et al.  Zika virus outbreak on Yap Island, Federated States of Micronesia. , 2009, The New England journal of medicine.

[92]  Albert D. M. E. Osterhaus,et al.  Dengue Virus Pathogenesis: an Integrated View , 2009, Clinical Microbiology Reviews.

[93]  Shibo Jiang,et al.  Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity , 2009, Virology.

[94]  W. Messer,et al.  Comparison of Plaque- and Flow Cytometry-Based Methods for Measuring Dengue Virus Neutralization , 2007, Journal of Clinical Microbiology.

[95]  G. Kuno,et al.  Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses , 2007, Archives of Virology.

[96]  K. Stiasny,et al.  Flavivirus membrane fusion. , 2006, The Journal of general virology.

[97]  Ting-Chao Chou,et al.  Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies , 2006, Pharmacological Reviews.

[98]  J. Kenar.  Reaction chemistry of gossypol and its derivatives , 2006 .

[99]  K. Dodou.  Investigations on gossypol: past and present developments , 2005, Expert opinion on investigational drugs.

[100]  R. Johnston,et al.  Flow Cytometry-Based Assay for Titrating Dengue Virus , 2005, Journal of Clinical Microbiology.

[101]  M. Álvarez,et al.  Improved Dengue Virus Plaque Formation on BHK21 and LLCMK 2 Cells: Evaluation of Some Factors , 2005 .

[102]  A. Debnath,et al.  N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion , 2004, Antimicrobial Agents and Chemotherapy.

[103]  P. Kovacic.  Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. , 2003, Current medicinal chemistry.

[104]  C. King,et al.  Flow Cytometry Compared with Indirect Immunofluorescence for Rapid Detection of Dengue Virus Type 1 after Amplification in Tissue Culture , 2001, Journal of Clinical Microbiology.

[105]  J. Roehrig,et al.  New Mouse Model for Dengue Virus Vaccine Testing , 1999, Journal of Virology.

[106]  D. Gubler,et al.  Dengue and dengue hemorrhagic fever. , 2014 .

[107]  S. Young,et al.  Synthesis and anti-HIV activity of 1,1'-dideoxygossypol and related compounds. , 1995, Journal of medicinal chemistry.

[108]  R F Schinazi,et al.  Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol. , 1993, Biochemical pharmacology.

[109]  K. Watanabe,et al.  Anti-fertility and other actions of gossypol analogues. , 1988, Contraception.

[110]  S. Matlin,et al.  Ultrastructural, fertility, and spermicidal studies with isomers and derivatives of gossypol in male hamsters. , 1987, Biology of reproduction.

[111]  S. Qian,et al.  Gossypol: a potential antifertility agent for males. , 1984, Annual review of pharmacology and toxicology.

[112]  N. Marchette,et al.  Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. , 1969, The American journal of tropical medicine and hygiene.

[113]  Seventeenth Meeting.  [Pan American Health Organization]. , 1968, Boletin de odontologia.