Reconsolidation: the advantage of being refocused

Ample evidence suggests that upon their retrieval, items in long-term memory enter a transient special state, in which they might become prone to change. The process that generates this state is dubbed 'reconsolidation'. The dominant conceptual framework in this revitalized field of memory research focuses on whether reconsolidation resembles consolidation, which is the process that converts an unstable short-term memory trace into a more stable long-term trace. However, this emphasis on the comparison of reconsolidation to consolidation deserves reassessment. Instead, the phenomenon of reconsolidation, irrespective of its relevance to consolidation, provides a unique opportunity to tap into the molecular, cellular and circuit correlates of memory persistence and retrieval, of which we currently know only little.

[1]  JaneR . Taylor,et al.  Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A , 2006, Nature Neuroscience.

[2]  B. Hars,et al.  Memory Consolidation and Reconsolidation in the Rat Pup Require Protein Synthesis , 2004, The Journal of Neuroscience.

[3]  Y. Dudai,et al.  Stability of Retrieved Memory: Inverse Correlation with Trace Dominance , 2003, Science.

[4]  Yadin Dudai,et al.  Reconsolidation of fresh, remote, and extinguished fear memory in medaka: old fears don't die , 2004, The European journal of neuroscience.

[5]  Y. Dudai.  The neurobiology of consolidations, or, how stable is the engram? , 2004, Annual review of psychology.

[6]  W. F. Prokasy,et al.  Classical conditioning II: Current research and theory. , 1972 .

[7]  M. E. Pedreira,et al.  Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction. , 2004, Learning & memory.

[8]  Alcino J. Silva,et al.  Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures , 2004, The Journal of Neuroscience.

[9]  K. Nader,et al.  Response to Alberini: right answer, wrong question , 2005, Trends in Neurosciences.

[10]  H. Maldonado,et al.  Memory strengthening by a real‐life episode during reconsolidation: an outcome of water deprivation via brain angiotensin II , 2005, The European journal of neuroscience.

[11]  Yadin Dudai,et al.  Amygdalar circuits required for either consolidation or extinction of taste aversion memory are not required for reconsolidation , 2004, The European journal of neuroscience.

[12]  Joseph E LeDoux,et al.  Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala , 2004, Neuroscience.

[13]  B. Everitt,et al.  Disrupting Reconsolidation of Drug Memories Reduces Cocaine-Seeking Behavior , 2005, Neuron.

[14]  M. Guha.  Memory from A to Z: Keywords, Concepts and Beyond , 2003 .

[15]  S. Tonegawa,et al.  Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval , 2022 .

[16]  H. Maldonado,et al.  Activation of the transcription factor NF-kappaB by retrieval is required for long-term memory reconsolidation. , 2005, Learning & memory.

[17]  D. Lewis.  Psychobiology of active and inactive memory. , 1979 .

[18]  R. Pitman,et al.  Conceptually Driven Pharmacologic Approaches to Acute Trauma , 2005, CNS Spectrums.

[19]  I. Izquierdo,et al.  Retrieval does not induce reconsolidation of inhibitory avoidance memory. , 2004, Learning & memory.

[20]  K. Giese,et al.  Memory Reconsolidation Engages Only a Subset of Immediate-Early Genes Induced during Consolidation , 2005, The Journal of Neuroscience.

[21]  B. Everitt,et al.  Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation , 2004, Science.

[22]  Y. Dudai,et al.  Rites of Passage of the Engram Reconsolidation and the Lingering Consolidation Hypothesis , 2004, Neuron.

[23]  M. E. Pedreira,et al.  Protein Synthesis Subserves Reconsolidation or Extinction Depending on Reminder Duration , 2003, Neuron.

[24]  Karim Nader,et al.  Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[25]  S. Rose,et al.  Reminder effects: the molecular cascade following a reminder in young chicks does not recapitulate that following training on a passive avoidance task , 2004, The European journal of neuroscience.

[26]  E. Tulving.  Elements of episodic memory , 1983 .

[27]  Ken Lukowiak,et al.  Impairing forgetting by preventing new learning and memory. , 2005, Behavioral neuroscience.

[28]  S. Rose,et al.  Recalling an aversive experience by day-old chicks is not dependent on somatic protein synthesis. , 2005, Learning & memory.

[29]  José María Delgado-García,et al.  Acquisition, Consolidation, Reconsolidation, and Extinction of Eyelid Conditioning Responses Require De Novo Protein Synthesis , 2005, The Journal of Neuroscience.

[30]  J. D. McGaugh,et al.  Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: the role of re-exposure duration. , 2006, Learning & memory.

[31]  F. Bermúdez-Rattoni,et al.  Protein synthesis underlies post-retrieval memory consolidation to a restricted degree only when updated information is obtained. , 2005, Learning & memory.

[32]  Randolf Menzel,et al.  Spontaneous Recovery from Extinction Depends on the Reconsolidation of the Acquisition Memory in an Appetitive Learning Paradigm in the Honeybee (Apis mellifera) , 2005, The Journal of Neuroscience.

[33]  Retrograde Amnesia , 2003 .

[34]  S. Sara.  Retrieval and reconsolidation: toward a neurobiology of remembering. , 2000, Learning & memory.

[35]  R. Rescorla.  A theory of pavlovian conditioning: The effectiveness of reinforcement and non-reinforcement , 1972 .

[36]  Karim Nader,et al.  Memory traces unbound , 2003, Trends in Neurosciences.

[37]  B. Balleine,et al.  Consolidation and Reconsolidation of Incentive Learning in the Amygdala , 2005, The Journal of Neuroscience.

[38]  C. Alberini,et al.  Linking New Information to a Reactivated Memory Requires Consolidation and Not Reconsolidation Mechanisms , 2005, PLoS biology.

[39]  R. Morris,et al.  Competing for Memory Hippocampal LTP under Regimes of Reduced Protein Synthesis , 2004, Neuron.

[40]  P. Balaban,et al.  Reconsolidation of a context long-term memory in the terrestrial snail requires protein synthesis. , 2005, Learning & memory.

[41]  Reconsolidation after remembering an odor-reward association requires NMDA receptors. , 2005, Learning & memory.

[42]  K. Nader,et al.  Characterization of Fear Memory Reconsolidation , 2004, The Journal of Neuroscience.

[43]  S. J. Martin,et al.  Forgetting, Reminding, and Remembering: The Retrieval of Lost Spatial Memory , 2004, PLoS biology.

[44]  Cristina M. Alberini,et al.  Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? , 2005, Trends in Neurosciences.

[45]  P. Dash,et al.  Inhibition of hippocampal protein synthesis following recall disrupts expression of episodic‐like memory in trace conditioning , 2005, Hippocampus.

[46]  Joseph E LeDoux,et al.  Activation of extracellular signal‐regulated kinase– mitogen‐activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioning , 2005, The European journal of neuroscience.