GENETIC PREDISPOSITION TO ISCHEMIC HEART DISEASE

[1]  Maria Laura De Marchis,et al.  Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels , 2018, International journal of molecular sciences.

[2]  Zhi Li,et al.  Effect of AMP‐activated protein kinase subunit alpha 2 (PRKAA2) genetic polymorphisms on susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a Chinese population , 2018, Journal of diabetes.

[3]  Pål Aukrust,et al.  Increased Levels of Lectin‐Like Oxidized Low‐Density Lipoprotein Receptor‐1 in Ischemic Stroke and Transient Ischemic Attack , 2018, Journal of the American Heart Association.

[4]  R. Fisberg,et al.  Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study. , 2017, Clinical nutrition.

[5]  Z. Wang,et al.  Relationship between inducible NOS single-nucleotide polymorphisms and hypertension in Han Chinese , 2018, Herz.

[6]  H. Deng,et al.  Novel common variants associated with body mass index and coronary artery disease detected using a pleiotropic cFDR method. , 2017, Journal of molecular and cellular cardiology.

[7]  T. Henle,et al.  Lectin-like oxidized low-density lipoprotein receptor-1 promotes endothelial dysfunction in LDL receptor knockout background. , 2017, Atherosclerosis. Supplements.

[8]  A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors , 2017, Scientific Reports.

[9]  M. Banach,et al.  The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction , 2017, Scientific Reports.

[10]  J. A. Thompson,et al.  Genetic Deletion of NADPH Oxidase 1 Rescues Microvascular Function in Mice With Metabolic Disease , 2017, Circulation research.

[11]  Xinchun Yang,et al.  The association of eight potentially functional polymorphisms in five adrenergic receptor-encoding genes with myocardial infarction risk in Han Chinese. , 2017, Gene.

[12]  Ruyao Wang,et al.  Microsatellite and Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 Promoter with Insulin Sensitivity and Insulin Secretion , 2017, Medical science monitor : international medical journal of experimental and clinical research.

[13]  Jesse M. Engreitz,et al.  A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression , 2017, Cell.

[14]  Stephen Burgess,et al.  Association of Genetic Variants Related to Serum Calcium Levels With Coronary Artery Disease and Myocardial Infarction , 2017, JAMA.

[15]  Chen Wang,et al.  Polymorphism in ERCC1 confers susceptibility of coronary artery disease and severity of coronary artery atherosclerosis in a Chinese Han population , 2017, Scientific Reports.

[16]  Qingxiao Fang,et al.  The Gas6 gene rs8191974 and Ap3s2 gene rs2028299 are associated with type 2 diabetes in the northern Chinese Han population. , 2017, Acta biochimica Polonica.

[17]  S. Humphries,et al.  Effect of Coronary Artery Disease risk SNPs on serum cytokine levels and cytokine imbalance in Premature Coronary Artery Disease. , 2017, Cytokine.

[18]  Xiang-Yang Zhang,et al.  Myeloperoxidase polymorphism and coronary artery disease risk , 2017, Medicine.

[19]  Kristin G Ardlie,et al.  Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease , 2017, Nature Genetics.

[20]  Ping Yang,et al.  Association of single nucleotide polymorphisms in the 5′ upstream region of the C4BPA gene with essential hypertension in a northeastern Han Chinese population , 2017, Molecular medicine reports.

[21]  Yufeng Yao,et al.  The association of six single nucleotide polymorphisms and their haplotypes in CDH13 with T2DM in a Han Chinese population , 2017, Medicine.

[22]  R. D. Rudic,et al.  Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction , 2017, Arteriosclerosis, thrombosis, and vascular biology.

[23]  S. Harrap,et al.  Familial Analysis of Epistatic and Sex-Dependent Association of Genes of the Renin–Angiotensin–Aldosterone System and Blood Pressure , 2017, Circulation. Cardiovascular genetics.

[24]  C. Xiao,et al.  Association of CYP17A1 Genetic Polymorphisms and Susceptibility to Essential Hypertension in the Southwest Han Chinese Population , 2017, Medical science monitor : international medical journal of experimental and clinical research.

[25]  S. Tang,et al.  Associations of CYP4A11 gene–gene and gene–smoking interactions with essential hypertension in the male eastern Chinese Han population , 2017, Clinical and experimental hypertension.

[26]  Andrew D. Johnson,et al.  Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms , 2017, Nature Genetics.

[27]  H. Baqai,et al.  The communal relation of MTHFR, MTR, ACE gene polymorphisms and hyperhomocysteinemia as conceivable risk of coronary artery disease. , 2017, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[28]  V. Stepanov,et al.  The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population , 2017, Clinical and experimental hypertension.

[29]  Vahagn Ohanyan,et al.  Kv1.3 channels facilitate the connection between metabolism and blood flow in the heart , 2017, Microcirculation.

[30]  Xiaofeng Zhu,et al.  Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations , 2017, PLoS genetics.

[31]  Y. Fujiwara,et al.  Identification of polymorphisms in 12q24.1, ACAD10, and BRAP as novel genetic determinants of blood pressure in Japanese by exome-wide association studies , 2017, Oncotarget.

[32]  Y. Izumiya,et al.  CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina , 2017, International journal of cardiology. Heart & vasculature.

[33]  V. Lánská,et al.  Polygenic hypercholesterolemia: examples of GWAS results and their replication in the Czech-Slavonic population. , 2017, Physiological research.

[34]  Z. Rancic,et al.  Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: Evaluation of the novel radiotracer [11C]RS-016 targeting CB2 in atherosclerosis. , 2017, Nuclear medicine and biology.

[35]  Yujing Li,et al.  Genetic association analysis of polymorphisms in PSD3 gene with obesity, type 2 diabetes, and HDL cholesterol. , 2017, Diabetes research and clinical practice.

[36]  K. Lunetta,et al.  A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women , 2017, PloS one.

[37]  G. Paré,et al.  The 9p21.3 locus and cardiovascular risk in familial hypercholesterolemia. , 2017, Journal of clinical lipidology.

[38]  He Zhang,et al.  Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease , 2017, Journal of the American College of Cardiology.

[39]  V. Sandrim,et al.  IL-6, TNF-α, and IL-10 levels/polymorphisms and their association with type 2 diabetes mellitus and obesity in Brazilian individuals , 2017, Archives of endocrinology and metabolism.

[40]  Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis , 2017, Cardiology research.

[41]  I. Drenjančević,et al.  Coronary microvascular dysfunction in diabetes mellitus , 2017, The Journal of international medical research.

[42]  Y. Nishijima,et al.  Contribution of KV1.5 Channel to Hydrogen Peroxide–Induced Human Arteriolar Dilation and Its Modulation by Coronary Artery Disease , 2016, Circulation research.

[43]  P. Nihoyannopoulos,et al.  The -174 G>C Interleukin-6 Gene Polymorphism is Associated with Angiographic Progression of Coronary Artery Disease over a 4-Year Period. , 2017, Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese.

[44]  A. Momin,et al.  Association of Single Nucleotide Polymorphisms of Adiponectin Gene with Type 2 Diabetes Mellitus, and Their Influence on Cardiovascular Risk Markers , 2017, Indian Journal of Clinical Biochemistry.

[45]  M. Habib,et al.  Association of endothelial nitric oxide synthase (eNOS) gene G894T polymorphism with hypertension risk and complications , 2016, Molecular and Cellular Biochemistry.

[46]  A. Dirican,et al.  Polymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients. , 2016, Clinical biochemistry.

[47]  K. Sakamoto,et al.  Sex differences in the impact of CYP2C19 polymorphisms and low-grade inflammation on coronary microvascular disorder. , 2016, American journal of physiology. Heart and circulatory physiology.

[48]  Jiantao Song,et al.  Association of Genetic Polymorphisms on VEGFA and VEGFR2 With Risk of Coronary Heart Disease , 2016, Medicine.

[49]  M. Pirinen,et al.  The Contribution of GWAS Loci in Familial Dyslipidemias , 2016, PLoS genetics.

[50]  Y. Deshaies,et al.  A CpG-SNP Located within the ARPC3 Gene Promoter Is Associated with Hypertriglyceridemia in Severely Obese Patients , 2016, Annals of Nutrition and Metabolism.

[51]  Y. Bossé,et al.  Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease. , 2016, Epigenomics.

[52]  Yeong-Renn Chen,et al.  Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction , 2016, Basic Research in Cardiology.

[53]  Ruth McPherson,et al.  Genetics of Coronary Artery Disease. , 2016, Circulation research.

[54]  A. Geurts,et al.  The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. , 2016, American journal of physiology. Heart and circulatory physiology.

[55]  Dongming Zhang,et al.  Association of Genetic Polymorphisms on Vascular Endothelial Growth Factor and its Receptor Genes with Susceptibility to Coronary Heart Disease , 2016, Medical science monitor : international medical journal of experimental and clinical research.

[56]  Huiping Zhang,et al.  Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population , 2015, Lipids in Health and Disease.

[57]  Jing He,et al.  Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation , 2015, Nature Genetics.

[58]  K. Bailey,et al.  Design of a randomized controlled trial of disclosing genomic risk of coronary heart disease: the Myocardial Infarction Genes (MI-GENES) study , 2015, BMC Medical Genomics.

[59]  M. Endres,et al.  Modifiable cardiovascular risk factors in adults aged 40–79 years in Germany with and without prior coronary heart disease or stroke , 2015, BMC Public Health.

[60]  F. Romeo,et al.  Oxidized LDL attenuates protective autophagy and induces apoptotic cell death of endothelial cells: Role of oxidative stress and LOX-1 receptor expression. , 2015, International journal of cardiology.

[61]  P. Libby,et al.  Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions. , 2015, European heart journal.

[62]  T. Beaty,et al.  Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians. , 2015, Journal of Clinical Endocrinology and Metabolism.

[63]  J. Leopold.  Microvascular dysfunction: genetic polymorphisms suggest sex-specific differences in disease phenotype. , 2014, Coronary artery disease.

[64]  J. Cunningham,et al.  Single nucleotide polymorphisms associated with abnormal coronary microvascular function , 2014, Coronary artery disease.

[65]  Yunchao Su,et al.  Increasing Muscle Mass Improves Vascular Function in Obese (db/db) Mice , 2014, Journal of the American Heart Association.

[66]  B. Saffari,et al.  Non-modifiable Factors of Coronary Artery Stenosis in Late Onset Patients with Coronary Artery Disease in Southern Iranian Population , 2014, Journal of cardiovascular and thoracic research.

[67]  C. Sena,et al.  Endothelial dysfunction - a major mediator of diabetic vascular disease. , 2013, Biochimica et biophysica acta.

[68]  R. Leis,et al.  Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case–control multicentre study , 2013, BMC Medical Genetics.

[69]  F. Fedele,et al.  Role of ion channels in coronary microcirculation: a review of the literature. , 2013, Future cardiology.

[70]  Peter Scarborough,et al.  Cardiovascular disease in Europe: epidemiological update. , 2014, European heart journal.

[71]  F. Fedele,et al.  Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease , 2013, Basic Research in Cardiology.

[72]  T. Villarreal-Molina,et al.  Single Nucleotide Polymorphisms within LIPA (Lysosomal Acid Lipase A) Gene Are Associated with Susceptibility to Premature Coronary Artery Disease. A Replication in the Genetic of Atherosclerotic Disease (GEA) Mexican Study , 2013, PloS one.

[73]  M. Eren,et al.  Evaluation of coronary microvascular function and nitric oxide synthase intron 4a/b polymorphism in patients with coronary slow flow , 2013, Coronary artery disease.

[74]  W. Shen,et al.  Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart , 2013, Circulation research.

[75]  W. Chung,et al.  A novel channelopathy in pulmonary arterial hypertension. , 2013, The New England journal of medicine.

[76]  A. Stewart,et al.  Genetics of Coronary Artery Disease in the 21st Century , 2012, Clinical cardiology.

[77]  L. Shaw,et al.  Myocardial Ischemia in Women: Lessons From the NHLBI WISE Study , 2012, Clinical cardiology.

[78]  F. Hu,et al.  Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies. , 2011, Journal of the American College of Cardiology.

[79]  M. Ackerman,et al.  Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations. , 2011, Journal of the American College of Cardiology.

[80]  B. Gao,et al.  Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. , 2011, Molecular aspects of medicine.

[81]  T. Isbir,et al.  Cox-2 gene polymorphism and IL-6 levels in coronary artery disease. , 2011, Genetics and molecular research : GMR.

[82]  M. Nothnagel,et al.  CDKN2BAS is associated with periodontitis in different European populations and is activated by bacterial infection , 2010, Journal of Medical Genetics.

[83]  Susan R. Heckbert,et al.  Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo , 2010, PLoS genetics.

[84]  M. Gooz.  ADAM-17: the enzyme that does it all , 2010, Critical reviews in biochemistry and molecular biology.

[85]  J. M. Lynch,et al.  PKC‐permitted elevation of sarcolemmal KATP concentration may explain female‐specific resistance to myocardial infarction , 2009, The Journal of physiology.

[86]  Nikolai Petrovsky,et al.  Common sequence variation in the VEGFA gene predicts risk of diabetic retinopathy. , 2009, Investigative ophthalmology & visual science.

[87]  M. Sturek,et al.  Impaired function of coronary BK(Ca) channels in metabolic syndrome. , 2009, American journal of physiology. Heart and circulatory physiology.

[88]  Diana C. Chong,et al.  Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation. , 2009, Developmental biology.

[89]  M. Yacoub,et al.  Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis , 2009, Nature Reviews Cardiology.

[90]  T. Lumley,et al.  Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study , 2009, Stroke.

[91]  Rachael,et al.  Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy. , 2008, Mayo Clinic proceedings.

[92]  G. King,et al.  Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes , 2007, Nature Clinical Practice Endocrinology &Metabolism.

[93]  K. Sunagawa,et al.  Vasospastic angina and microvascular angina are differentially influenced by PON1 A632G polymorphism in the Japanese. , 2005, Circulation journal : official journal of the Japanese Circulation Society.

[94]  A. Fowler,et al.  HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. , 2005, American journal of physiology. Heart and circulatory physiology.

[95]  S. Gupte,et al.  Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[96]  C. Stehouwer,et al.  Endothelial Dysfunction, Cellular Adhesion Molecules and the Metabolic Syndrome , 2005, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[97]  H. Drexler,et al.  Endothelial function: a critical determinant in atherosclerosis? , 2004, Circulation.

[98]  S. Blankenberg,et al.  Adhesion molecules and atherosclerosis. , 2003, Atherosclerosis.

[99]  D. Kereiakes,et al.  Endothelial dysfunction. , 2003, Circulation.

[100]  D. Collen,et al.  Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories. , 2003, Biochimica et biophysica acta.

[101]  P. Libby.  Inflammation in atherosclerosis , 2002, Nature.

[102]  Y. Ueki,et al.  Comparison of serum concentrations of soluble adhesion molecules in diabetic microangiopathy and macroangiopathy , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[103]  D. Harrison,et al.  Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. , 2000, Circulation research.

[104]  R. de Caterina.  Endothelial dysfunctions: common denominators in vascular disease. , 2000, Current opinion in lipidology.

[105]  J. Loscalzo,et al.  Cellular adhesion molecules and atherogenesis. , 1999, The American journal of medicine.

[106]  K. Williams,et al.  Atherosclerosis--an inflammatory disease. , 1999, The New England journal of medicine.

[107]  A. Yeung,et al.  The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. , 1995, The New England journal of medicine.