Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.

[1]  S. Sligar,et al.  Proton coupling in the cytochrome P-450 spin and redox equilibria. , 1979, Biochemistry.

[2]  S. Kawato,et al.  Evidence from cross‐linking and rotational diffusion studies that cytochrome P450 can form molecular aggregates in rabbit‐liver microsomal membranes , 1980, FEBS letters.

[3]  R. Greinert,et al.  Cytochrome P-450 rotamers control mixed-function oxygenation in reconstituted membranes. Rotational diffusion studied by delayed fluorescence depolarizationd` , 1982 .

[4]  S. Kawato,et al.  Rotation of cytochrome P-450. I. Investigations of protein-protein interactions of cytochrome P-450 in phospholipid vesicles and liver microsomes. , 1982, The Journal of biological chemistry.

[5]  M. Marden,et al.  The pressure dependence of the spin equilibrium in camphor-bound ferric cytochrome P-450. , 2005, European journal of biochemistry.

[6]  S. Sligar,et al.  High-pressure investigations of cytochrome P-450 spin and substrate binding equilibria. , 1985, Archives of biochemistry and biophysics.

[7]  E. Orlova,et al.  Quaternary structure of the liver microsomal cytochrome P‐450 , 1986, FEBS letters.

[8]  G. H. Hoa,et al.  P-450 binding to substrates camphor and linalool versus pressure. , 1987, Archives of biochemistry and biophysics.

[9]  C. Di Primo,et al.  Conformational changes of cytochromes P-450cam and P-450lin induced by high pressure. , 1989, Biochemistry.

[10]  M. J. Coon,et al.  Membrane topology of microsomal cytochrome P-450: saturation transfer EPR and freeze-fracture electron microscopy studies. , 1990, Biochemical and biophysical research communications.

[11]  C. Di Primo,et al.  Effect of the tyrosine 96 hydrogen bond on the inactivation of cytochrome P-450cam induced by hydrostatic pressure. , 1990, European journal of biochemistry.

[12]  P. Berndt,et al.  Cytochrome P‐450LM2 oligomers in proteoliposomes , 1990, FEBS letters.

[13]  H. Gelboin,et al.  Interactions among cytochromes P-450 in the endoplasmic reticulum. Detection of chemically cross-linked complexes with monoclonal antibodies. , 1991, The Journal of biological chemistry.

[14]  C. Di Primo,et al.  Heme-pocket-hydration change during the inactivation of cytochrome P-450camphor by hydrostatic pressure. , 1992, European journal of biochemistry.

[15]  G. H. Hoa,et al.  High pressure induced inactivation of ferrous cytochrome P-450 LM2 (IIB4) CO complex: evidence for the presence of two conformers in the oligomer. , 1992, Biochemical and Biophysical Research Communications - BBRC.

[16]  D. Mansuy,et al.  Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5. , 1992, European journal of biochemistry.

[17]  C. Di Primo,et al.  A critical role of protein‐bound water in the catalytic cycle of cytochrome P‐450 camphor , 1992, FEBS letters.

[18]  J Deisenhofer,et al.  Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's. , 1993, Science.

[19]  V. Tsuprun,et al.  Cytochrome P‐450: hexameric structure of the purified LM4 form , 1993, FEBS letters.

[20]  M. Delaforge,et al.  High affinity of ergopeptides for cytochromes P450 3A. Importance of their peptide moiety for P450 recognition and hydroxylation of bromocriptine. , 1994, European Journal of Biochemistry.

[21]  A. P. Koley,et al.  CO Binding Kinetics of Human Cytochrome P450 3A4 , 1995, Journal of Biological Chemistry.

[22]  G. P. Kuznetsova,et al.  High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers. , 1995, Archives of biochemistry and biophysics.

[23]  C. Di Primo,et al.  Antagonistic effects of hydrostatic pressure and osmotic pressure on cytochrome P-450cam spin transition. , 1995, Biophysical journal.

[24]  M. Alterman,et al.  Effect of different solubilizing agents on the aggregation state and catalytic activity of two purified rabbit cytochrome P450 isozymes, CYP1A2 (LM4) and CYP2B4 (LM2). , 1995, Biochemical and biophysical research communications.

[25]  D. Mansuy,et al.  Thermodynamic studies of substrate binding and spin transitions in human cytochrome P-450 3A4 expressed in yeast microsomes. , 1996, The Biochemical journal.

[26]  K. Heremans.  High pressure research in the biosciences and biotechnology : proceedings of the XXXIVth Meeting of the European High Pressure Research Group, Leuven, Belgium, September 1-5, 1996 , 1997 .

[27]  N. Bec,et al.  A central role for water in the control of the spin state of cytochrome P-450scc. , 1997, European Journal of Biochemistry.

[28]  J. Liu,et al.  Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation. , 1998, Archives of biochemistry and biophysics.

[29]  K. Heremans,et al.  Protein structure and dynamics at high pressure. , 1998, Biochimica et biophysica acta.

[30]  P. R. Montellano,et al.  PRESSURE-INDUCED DEFORMATION OF THE CYTOCHROME P450CAM ACTIVE SITE , 1998 .

[31]  S. Sligar,et al.  Characterization of a cytochrome P450 from the acidothermophilic archaea Sulfolobus solfataricus. , 1998, Biochemical and biophysical research communications.

[32]  N. Bec,et al.  HIGH CONFORMATIONAL STABILITY OF CYTOCHROME P-450 1A2. EVIDENCE FROM UV ABSORPTION SPECTRA , 1998 .

[33]  J. Peterson,et al.  Dynamics of protein-bound water in the heme domain of P450BM3 studied by high-pressure spectroscopy: comparison with P450cam and P450 2B4. , 1999, Biochemistry.

[34]  F. Guengerich,et al.  Cytochrome P-450 3A4: regulation and role in drug metabolism. , 1999, Annual review of pharmacology and toxicology.

[35]  G. Miller,et al.  Elucidation of distinct ligand binding sites for cytochrome P450 3A4. , 2000, Biochemistry.

[36]  A. Archakov,et al.  Stabilization of P450 2B4 by its association with P450 1A2 revealed by high-pressure spectroscopy. , 2000, Biochemical and biophysical research communications.

[37]  P. Souček,et al.  Flexibility and stability of the structure of cytochromes P450 3A4 and BM-3. , 2000, European journal of biochemistry.

[38]  J. Halpert,et al.  Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity. , 2001, Biochemistry.

[39]  T. Baillie,et al.  A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4* , 2001, Journal of Biological Chemistry.

[40]  P. Ortiz de Montellano,et al.  Reversible pressure deformation of a thermophilic cytochrome P450 enzyme (CYP119) and its active-site mutants. , 2001, Journal of the American Chemical Society.

[41]  C. Jung.  Cytochrome P-450-CO and substrates: lessons from ligand binding under high pressure. , 2002, Biochimica et biophysica acta.

[42]  R. Macgregor.  The interactions of nucleic acids at elevated hydrostatic pressure. , 2002, Biochimica et biophysica acta.

[43]  J. Kornblatt,et al.  The effects of osmotic and hydrostatic pressures on macromolecular systems. , 2002, Biochimica et Biophysica Acta.

[44]  S. Sligar,et al.  High pressure, a tool for exploring heme protein active sites. , 2002, Biochimica et Biophysica Acta.

[45]  Sean Ekins,et al.  In vitro and pharmacophore insights into CYP3A enzymes. , 2003, Trends in pharmacological sciences.

[46]  J. Halpert,et al.  Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study. , 2003, Drug metabolism and disposition: the biological fate of chemicals.