The Effect of Tubocurarine and Alcuronium on Suxamethonium‐Induced Changes in Cardiac Rate and Rhythm

The effect of prior administration of tubocurarine (5 mg) or alcuronium (3 mg) on changes in cardiac rate and rhythm caused by the second dose of suxamethonium (1 mg/kg) during halothane‐nitrous oxide‐oxygen anaesthesia was studied in 60 patients. Tubocurarine and, particularly alcuronium were found to prevent bradyarrhythmias caused by the second dose of suxamethonium. These non‐depolarizing relaxants had a moderate stabilizing action on the cardiac rhythm also during intubation and the commencement of artificial ventilation. The relaxation obtained by the first dose of suxamethonium (1 mg/kg) was sufficient to permit quiet intubation in all cases. The use of a non‐depolarizing muscle relaxant prior to suxamethonium during halothane‐nitrous oxide‐oxygen anaesthesia is recommended.

[1]  A. A. Birch,et al.  CHANGES IN SERUM POTASSIUM RESPONSE TO SUCCINYLCHOLINE FOLLOWING TRAUMA , 1971 .

[2]  D. Cour.  PREVENTION OF RISE IN INTRAGASTRIC PRESSURE DUE TO SUXAMETHONIUM FASCICULATIONS BY PRIOR DOSE OF D‐TUBOCURARINE , 1970 .

[3]  T. P. Beach,et al.  Succinylcholine--danger in the spinal-cord-injured patient. , 1970, Anesthesiology.

[4]  L. Cooperman,et al.  Massive hyperkalemia after administration of succinylcholine. , 1970, Anesthesiology.

[5]  R. Mazze,et al.  Hyperkalemia and Cardiovascular Collapse Following Administration of Succinylcholine to the Traumatized Patient , 1969, Anesthesiology.

[6]  L. Cooperman,et al.  Changes in plasma potassium concentration after depolarizing blockers in anaesthetized man. , 1969, British journal of anaesthesia.

[7]  A. A. Birch,et al.  Changes in serum potassium response to succinylcholine following trauma. , 1969, JAMA.

[8]  J. Dillon,et al.  Clinical studies of the interaction between d-tubocurarine and succinylcholine. , 1969 .

[9]  J. Dillon,et al.  Clinical Studies of the Interaction between d-Tubocurarine and Succinylcholine , 1969, Anesthesiology.

[10]  H. Wüthrich,et al.  The clinical importance of hyperkalaemia following suxamethonium administration. , 1969, British journal of anaesthesia.

[11]  T. Tammisto,et al.  The effect of alcuronium and tubocurarine on blood pressure and heart rate: a clinical comparison. , 1969, British journal of anaesthesia.

[12]  W. Riker,et al.  Pharmacology of motor nerve terminals. , 1969, Annual review of pharmacology.

[13]  M. Airaksinen,et al.  THE INHIBITORY EFFECT OF D‐TUBOCURARINE ON THE INCREASE OF SERUM‐CREATINE‐KINASE ACTIVITY PRODUCED BY INTERMITTENT SUXAMETHONIUM ADMINISTRATION DURING HALOTHANE ANAESTHESIA , 1967, Acta anaesthesiologica Scandinavica.

[14]  W. List.  Serum potassium changes during induction of anaesthesia. , 1967, British journal of anaesthesia.

[15]  T. H. Joyce,et al.  Succinylcholine danger in the burned patient. , 1967, Anesthesiology.

[16]  S. Kenny.  The Adelaide ventilation guide. , 1967, British journal of anaesthesia.

[17]  L. Juhlin,et al.  Basophil leukocytes in cantharidin blisters on patients with internal disorders. , 2009, Acta medica Scandinavica.

[18]  L. W. Fabian,et al.  VENTRICULAR ARRHYTHMIAS INDUCED BY SUCCINYLCHOLINE IN DIGITALIZED PATIENTS: A PRELIMINARY REPORT , 1963 .

[19]  C. Whitcher,et al.  Observations on the Mechanism of Succinyldicholine‐Induced Cardiac Arrhythmias , 1963, Anesthesiology.

[20]  R. Dripps,et al.  EFFECTS OF INTRAVENOUSLY ADMINISTERED SUCCINYLDICHOLINE ON CARDIAC RATE, RHYTHM, AND ARTERIAL BLOOD PRESSURE IN ANESTHETIZED MAN , 1961, Anesthesiology.

[21]  D. D. Morris,et al.  SUXAMETHONIUM CHLORIDE ADMINISTRATION AND POSTOPERATIVE MUSCLE PAIN , 1958 .

[22]  M. Leigh,et al.  BRADYCARDIA FOLLOWING INTRAVENOUS ADMINISTRATION OF SUCCINYLCHOLINE CHLORIDE TO INFANTS AND CHILDREN , 1957, Anesthesiology.

[23]  D. D. Morris,et al.  Suxamethonium Chloride Administration and Post-operative Muscle Pain , 1957 .

[24]  W. Riker,et al.  THE PHARMACOLOGY OF FLAXEDIL, WITH OBSERVATIONS ON CERTAIN ANALOGS , 1951, Annals of the New York Academy of Sciences.