The ACTH test in the diagnosis of hirsutism.

The ACTH test has been used to confirm the diagnosis of adrenal insufficiency and the classic and the non-classic adrenal hyperplasia due to the 3-HSD, 21 OH e 110H deficiencies. This article reviews the historical aspects of the use of ACTH in the diagnosis of hirsutism and points out its mains indications. In spite of new biological molecular advances in the diagnosis of adrenal enzymatic deficiencies, the use of the ACTH test can help the physician to predict both genothipus and fenothipus in populations with hyperandrogenic manifestations due to non-classical or late-onset congenital adrenal hyperplasia.

[1]  Marco Fábio,et al.  Avaliação da atividade de 3B-hidroxiesteroide desidrogenase em mulheres hirsutas após estímulo com ACTH DEPOT. , 1994 .

[2]  D. Ehrmann,et al.  Ovarian steroidogenic responses to gonadotropin-releasing hormone agonist testing with nafarelin in hirsute women with adrenal responses to adrenocorticotropin suggestive of 3 beta-hydroxy-delta 5-steroid dehydrogenase deficiency. , 1993, The Journal of clinical endocrinology and metabolism.

[3]  A. Rösler,et al.  Secondary biosynthetic defects in women with late-onset congenital adrenal hyperplasia. , 1990, The New England journal of medicine.

[4]  R. Azziz,et al.  21-Hydroxylase deficiency in female hyperandrogenism: screening and diagnosis. , 1989, The Journal of clinical endocrinology and metabolism.

[5]  P. Fossati,et al.  Clinical and biological phenotypes in late-onset 21-hydroxylase deficiency. , 1986, The Journal of clinical endocrinology and metabolism.

[6]  J. Melby,et al.  Discordance of plasma DHEA-S, DHEA, and cortisol responses with various ACTH regimens. , 1985, Metabolism: clinical and experimental.

[7]  M. New,et al.  Late-onset adrenal steroid 3 beta-hydroxysteroid dehydrogenase deficiency. I. A cause of hirsutism in pubertal and postpubertal women. , 1985, The Journal of clinical endocrinology and metabolism.

[8]  R. Chang,et al.  The incidence of late-onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency among hirsute women. , 1984, The Journal of clinical endocrinology and metabolism.

[9]  J. Opitz,et al.  Nonsalt-losing congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency with normal glomerulosa function. , 1983, The Journal of clinical endocrinology and metabolism.

[10]  R. Lobo,et al.  Evidence for reduced 3 beta-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome. , 1981, The Journal of clinical endocrinology and metabolism.

[11]  I. Schiff,et al.  Abnormal adrenal responses to adrenocorticotropic hormone in hyperandrogenic women. , 1980, Fertility and sterility.

[12]  T Yamaji,et al.  Plasma dehydroepiandrosterone sulfate in normal and pathological conditions. , 1969, The Journal of clinical endocrinology and metabolism.

[13]  G. W. Thorn,et al.  Use of ACTH in the diagnosis of adrenal cortical insufficiency. , 1955, The American journal of medicine.

[14]  G. W. Thorn,et al.  A test for adrenal cortical insufficiency; the response to pituitary andrenocorticotropic hormone. , 1948, Journal of the American Medical Association.