Brain regional angiogenic potential at the neurovascular unit during normal aging

[1]  D. Vivien,et al.  Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF , 2011, Neurobiology of Learning and Memory.

[2]  M. Burnett,et al.  Aging Causes Collateral Rarefaction and Increased Severity of Ischemic Injury in Multiple Tissues , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[3]  C. Bass,et al.  Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression , 2011, Neuroscience.

[4]  J. LaManna,et al.  Hypoxia-induced angiogenesis is delayed in aging mouse brain , 2011, Brain Research.

[5]  P. Grammas,et al.  Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease , 2011, Journal of Neuroinflammation.

[6]  W. Brown,et al.  Review: Cerebral microvascular pathology in ageing and neurodegeneration , 2011, Neuropathology and applied neurobiology.

[7]  D. Feng,et al.  From the vascular microenvironment to neurogenesis , 2011, Brain Research Bulletin.

[8]  S. Menon,et al.  Microarray studies in pulmonary arterial hypertension , 2011, International journal of clinical practice. Supplement.

[9]  J. LaManna,et al.  Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain , 2010, Brain Research.

[10]  B. Zlokovic,et al.  Neurodegeneration and the neurovascular unit , 2010, Nature Medicine.

[11]  Robert A. Smith,et al.  Angiogenesis in old-aged subjects after ischemic stroke: a cautionary note for investigators , 2010, Journal of angiogenesis research.

[12]  J. Hebling,et al.  Hypoxia enhances the angiogenic potential of human dental pulp cells. , 2010, Journal of endodontics.

[13]  L. McCullough,et al.  The Blood–Brain Barrier: Geriatric Relevance of a Critical Brain–Body Interface , 2010, Journal of the American Geriatrics Society.

[14]  Yong Tang,et al.  Stereological Investigation of Age‐Related Changes of the Capillaries in White Matter , 2010, Anatomical record.

[15]  J. LaManna,et al.  In the hypoxic central nervous system, endothelial cell proliferation is followed by astrocyte activation, proliferation, and increased expression of the α6β4 integrin and dystroglycan , 2010, Glia.

[16]  C. Rosen,et al.  Pathophysiology of the vascular wall and its relevance for cerebrovascular disorders in aged rodents. , 2010, Current neurovascular research.

[17]  R. Watts,et al.  Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier. , 2010, Annual review of neuroscience.

[18]  T. Yan,et al.  Physical exercise induces expression of CD31 and facilitates neural function recovery in rats with focal cerebral infarction , 2010, Neurological research.

[19]  G. Sorrentino,et al.  Biological Mechanisms of Physical Activity in Preventing Cognitive Decline , 2010, Cellular and Molecular Neurobiology.

[20]  D. Crowe,et al.  Chronologic aging decreases tumor angiogenesis and metastasis in a mouse model of head and neck cancer. , 2010, International journal of oncology.

[21]  Stephen R. Aylward,et al.  The effects of healthy aging on intracerebral blood vessels visualized by magnetic resonance angiography , 2010, Neurobiology of Aging.

[22]  J. Pachter,et al.  Endothelial cell heterogeneity of blood‐brain barrier gene expression along the cerebral microvasculature , 2009, Journal of neuroscience research.

[23]  N. Ferrara VEGF-A: a critical regulator of blood vessel growth. , 2009, European cytokine network.

[24]  J K Smith,et al.  The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography , 2009, American Journal of Neuroradiology.

[25]  J. Madri,et al.  Modeling the neurovascular niche: implications for recovery from CNS injury. , 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[26]  Peter J Clark,et al.  Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain , 2009, Hippocampus.

[27]  P. Carmeliet,et al.  The neurovascular link in health and disease: an update. , 2009, Trends in molecular medicine.

[28]  Yang-ming Yang,et al.  eNOS uncoupling and endothelial dysfunction in aged vessels. , 2009, American journal of physiology. Heart and circulatory physiology.

[29]  D. Ferriero,et al.  Signaling pathway involved in hypoxia-inducible factor-1α regulation in hypoxic-ischemic cortical neurons in vitro , 2009, Neuroscience Letters.

[30]  K. Arai,et al.  Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke , 2009, The FEBS journal.

[31]  J. LaManna,et al.  Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain. , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

[32]  J. Wykrzykowska,et al.  Impact of aging on the angiogenic potential of the myocardium: implications for angiogenic therapies with emphasis on sirtuin agonists. , 2009, Recent patents on cardiovascular drug discovery.

[33]  Joanna M. Wardlaw,et al.  Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis , 2009, Neurobiology of Aging.

[34]  A. Rodriguez-Perez,et al.  Aging and Sedentarism Decrease Vascularization and VEGF Levels in the Rat Substantia Nigra. Implications for Parkinson's Disease , 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[35]  Tomohiro Miike,et al.  Regional heterogeneity of substance P-induced endothelium-dependent contraction, relaxation, and -independent contraction in rabbit pulmonary arteries. , 2008, Life sciences.

[36]  Huafeng Zhang,et al.  Age‐dependent impairment of HIF‐1α expression in diabetic mice: Correction with electroporation‐facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells , 2008, Journal of cellular physiology.

[37]  Carl W. Cotman,et al.  Gene expression changes in the course of normal brain aging are sexually dimorphic , 2008, Proceedings of the National Academy of Sciences.

[38]  J. Pachter,et al.  Validation of immuno-laser capture microdissection coupled with quantitative RT-PCR to probe blood–brain barrier gene expression in situ , 2008, Journal of Neuroscience Methods.

[39]  Joakim Ekstrand,et al.  Environmental enrichment, exercise and corticosterone affect endothelial cell proliferation in adult rat hippocampus and prefrontal cortex , 2008, Neuroscience Letters.

[40]  H. Kainulainen,et al.  Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice , 2008, Cardiovascular diabetology.

[41]  P. Carmeliet,et al.  Neurovascular signalling defects in neurodegeneration , 2008, Nature Reviews Neuroscience.

[42]  V. Velebný,et al.  Effect of advanced glycation endproducts on gene expression profiles of human dermal fibroblasts , 2008, Biogerontology.

[43]  P. Schimmel,et al.  Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine. , 2008, Methods.

[44]  Yuchuan Ding,et al.  Forced, not voluntary, exercise effectively induces neuroprotection in stroke , 2008, Acta Neuropathologica.

[45]  J. Rak,et al.  Atherosclerosis and vascular aging as modifiers of tumor progression, angiogenesis, and responsiveness to therapy. , 2007, The American journal of pathology.

[46]  J. LaManna,et al.  Physiologic angiodynamics in the brain. , 2007, Antioxidants & redox signaling.

[47]  F. Mora,et al.  Aging, plasticity and environmental enrichment: Structural changes and neurotransmitter dynamics in several areas of the brain , 2007, Brain Research Reviews.

[48]  J. LaManna,et al.  Cerebral angiogenic factors, angiogenesis, and physiological response to chronic hypoxia differ among four commonly used mouse strains. , 2007, Journal of applied physiology.

[49]  Guo-Yuan Yang,et al.  Therapeutic Angiogenesis for Brain Ischemia: A Brief Review , 2007, Journal of Neuroimmune Pharmacology.

[50]  B. Hempstead,et al.  Brain-derived neurotrophic factor: a newly described mediator of angiogenesis. , 2007, Trends in cardiovascular medicine.

[51]  F. Rengo,et al.  Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[52]  Shuzhen Guo,et al.  Cell–cell Signaling in the Neurovascular Unit , 2007, Neurochemical Research.

[53]  Fred H. Gage,et al.  An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus , 2007, Proceedings of the National Academy of Sciences.

[54]  S. Itohara,et al.  Matrix Metalloproteinase-2 Plays a Critical Role in the Pathogenesis of White Matter Lesions After Chronic Cerebral Hypoperfusion in Rodents , 2006, Stroke.

[55]  M A Rupnick,et al.  Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy. , 2006, Microvascular research.

[56]  J. O'Brien,et al.  White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury , 2006, Stroke.

[57]  T. Otsuki,et al.  Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts. , 2006, American journal of physiology. Heart and circulatory physiology.

[58]  M. Mattson,et al.  Ageing and neuronal vulnerability , 2006, Nature Reviews Neuroscience.

[59]  Jie Li,et al.  Cerebral angiogenesis and expression of angiogenic factors in aging rats after exercise. , 2006, Current neurovascular research.

[60]  J. Pachter,et al.  Selective capture of endothelial and perivascular cells from brain microvessels using laser capture microdissection. , 2005, Brain research. Brain research protocols.

[61]  Carl Johan Sundberg,et al.  Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans , 2005, BMC Biology.

[62]  T. Davis,et al.  The Blood-Brain Barrier/Neurovascular Unit in Health and Disease , 2005, Pharmacological Reviews.

[63]  M. Chopp,et al.  Functional Recovery in Aged and Young Rats After Embolic Stroke: Treatment With a Phosphodiesterase Type 5 Inhibitor , 2005, Stroke.

[64]  J. Pachter,et al.  Where is the blood–brain barrier … really? , 2005, Journal of neuroscience research.

[65]  T. Skalak,et al.  Angiogenesis and Microvascular Remodeling: A Brief History and Future Roadmap , 2005, Microcirculation.

[66]  J. LaManna,et al.  The neurovascular unit and its growth factors: coordinated response in the vascular and nervous systems , 2004, Neurological research.

[67]  Carl D Langefeld,et al.  Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosis. , 2004, Radiology.

[68]  I. Kohane,et al.  Gene regulation and DNA damage in the ageing human brain , 2004, Nature.

[69]  J. LaManna,et al.  Hypoxic Regulation of Angiopoietin-2 Expression in Endothelial Cells* , 2004, Journal of Biological Chemistry.

[70]  P. Sham,et al.  Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease , 2004, Stroke.

[71]  M. Reed,et al.  Impaired angiogenesis in the aged. , 2004, Science of Aging Knowledge Environment.

[72]  M. Endres,et al.  Physical Training Increases Endothelial Progenitor Cells, Inhibits Neointima Formation, and Enhances Angiogenesis , 2004 .

[73]  S. Fujimoto,et al.  [Vasculogenesis and angiogenesis]. , 2003, Journal of UOEH.

[74]  David Botstein,et al.  Endothelial cell diversity revealed by global expression profiling , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[75]  E. Sadoun,et al.  Impaired Angiogenesis in Aging Is Associated with Alterations in Vessel Density, Matrix Composition, Inflammatory Response, and Growth Factor Expression , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[76]  E. Sadoun,et al.  Inhibited angiogenesis in aging: a role for TIMP-2. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[77]  G. Thurston Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis , 2003, Cell and Tissue Research.

[78]  P. Carmeliet Angiogenesis in health and disease , 2003, Nature Medicine.

[79]  David R. Riddle,et al.  Microvascular plasticity in aging , 2003, Ageing Research Reviews.

[80]  D. Charnock-Jones,et al.  Expression of CD105 (endoglin) in arteriolar endothelial cells of human endometrium throughout the menstrual cycle. , 2002, Reproduction.

[81]  Leonardo Pantoni,et al.  Pathophysiology of Age-Related Cerebral White Matter Changes , 2002, Cerebrovascular Diseases.

[82]  J. Mulliken,et al.  Molecular genetics of vascular malformations. , 2001, Matrix biology : journal of the International Society for Matrix Biology.

[83]  F. Peale,et al.  Gene profiling techniques and their application in angiogenesis and vascular development , 2001, The Journal of pathology.

[84]  Hirofumi Tanaka,et al.  Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men , 2000, Circulation.

[85]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[86]  L. Ghiadoni,et al.  Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. , 2000, Circulation.

[87]  StefanoTaddei,et al.  Physical Activity Prevents Age-Related Impairment in Nitric Oxide Availability in Elderly Athletes , 2000 .

[88]  P. Carmeliet Mechanisms of angiogenesis and arteriogenesis , 2000, Nature Medicine.

[89]  J. Isner,et al.  Age-dependent impairment of angiogenesis. , 1999, Circulation.

[90]  C. Bucana,et al.  Regulation of distinct steps of angiogenesis by different angiogenic molecules. , 1998, International journal of oncology.

[91]  Thomas N. Sato,et al.  Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. , 1997, Science.

[92]  J. Aten,et al.  Measurement of co‐localization of objects in dual‐colour confocal images , 1993, Journal of microscopy.

[93]  R. Collins,et al.  A quantitative study of cerebrovascular variation in inbred mice. , 1990, Journal of anatomy.

[94]  W. Greenough,et al.  Progressive failure of cerebral angiogenesis supporting neural plasticity in aging rats , 1989, Neurobiology of Aging.

[95]  W. Kuschinsky,et al.  Interdependency of local capillary density, blood flow, and metabolism in rat brains. , 1986, The American journal of physiology.

[96]  H. Davson Blood–brain barrier , 1977, Nature.

[97]  W. Hancock,et al.  Analysis of mouse brain microvascular endothelium using laser capture microdissection coupled with proteomics. , 2011, Methods in molecular biology.

[98]  Raj N Kalarianure,et al.  Vascular basis for brain degeneration : faltering controls and risk factors for dementia , 2010 .

[99]  M. Schwartz,et al.  Stem Cells , Tissue Engineering and Hematopoietic Elements Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal Modeling the Neurovascular Niche , 2009 .

[100]  D. Riddle,et al.  Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[101]  W. Aird Endothelium in health and disease. , 2008, Pharmacological reports : PR.

[102]  David R. Riddle,et al.  Regulation of Cerebrovascular Aging , 2007 .

[103]  J. LaManna,et al.  Is cycloxygenase-2 (COX-2) a major component of the mechanism responsible for microvascular remodeling in the brain? , 2006, Advances in experimental medicine and biology.

[104]  G. Zoccoli,et al.  Density of perfused brain capillaries in the aged rat during the wake-sleep cycle , 1999, Experimental Brain Research.