Effect of oral feeding of essence of chicken on the level of 5-hydroxyindole acetic acid in the cerebrospinal fluid of the rat.

The effect of oral feeding of a commercial preparation of essence of chicken (Brand's Essence of Chicken, BEC) on the level of 5-hydroxyindole acetic acid (5-HIAA) in the cerebrospinal fluid (CSF) of the rat was investigated. BEC, when fed to the rat for a period of 3 days, significantly increased the CSF level of 5-HIAA in seven out of 12 animals studied. As the level of CSF 5-HIAA is taken as an indication of 5-hydroxytryptamine (5-HT) activity in the brain, it is possible that BEC increased brain 5-HT activity. This increase was not due to the ingestion of tryptophan, the primary precursor of 5-HT, because BEC contains undetectable level of tryptophan. The data indicate that by causing an increase in brain 5-HT activity, consumption of BEC may lead to the activation of 5-HT-dependent physiological process like sleep improvement, mood elevation, analgesia, facilitation of motor output and regulation of circadian rhythm. However, such a possibility remains to be further investigated.

[1]  A. Cho,et al.  Enantiomeric differences in the effects of 3,4-methylenedioxymethamphetamine on extracellular monoamines and metabolites in the striatum of freely-moving rats: An in vivo microdialysis study , 1990, Neuropharmacology.

[2]  B. Ho,et al.  Serotonin in biological psychiatry. , 1982, Advances in biochemical psychopharmacology.

[3]  J. B. Martin,et al.  TRYPTOPHAN AND 5‐HYDROXYINDOLEACETIC ACID IN HUMAN CEREBROSPINAL FLUID , 1974, Journal of neurochemistry.

[4]  T. Hsu,et al.  Sensitive assays for the determination of monoamine oxidase and phenol sulphotransferase activity in small tissue samples. , 1990, Journal of Pharmacological Methods.

[5]  T. Hsu,et al.  Levels of dopamine and 3,4-dihydroxyphenylacetic acid in the adenohypophysis of normo- and hypertensive rats. , 1990, Clinical and experimental hypertension. Part A, Theory and practice.

[6]  A. Williams,et al.  Use of a traditional blood remedy. A study on regular blood donors , 1993 .

[7]  J. Miyamoto,et al.  Efflux of 5-HIAA form 5-HT neurons: A membrane potential-dependent process , 1990, Physiology & Behavior.

[8]  M. Héry,et al.  Serotonin and the regulation of pituitary hormone secretion and of neuroendocrine rhythms. , 1981, Journal de physiologie.

[9]  M. Roberts.  5-Hydroxytryptamine and antinociception , 1984, Neuropharmacology.

[10]  B. Jacobs,et al.  5-HT and motor control: a hypothesis , 1993, Trends in Neurosciences.

[11]  C. Geissler,et al.  Large acute thermic response to chicken essence in humans , 1989 .

[12]  C. Dugovic,et al.  Serotonin and Sleep‐Wakefulness , 1990, Annals of the New York Academy of Sciences.

[13]  M. Sim,et al.  Discovery of a novel soluble form of monoamine oxidase in the rat brain. , 1992, Biochemical pharmacology.

[14]  G. Ashcroft,et al.  Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain. , 1970, Brain : a journal of neurology.

[15]  M. Lader,et al.  The acute effects of oral (--)-tryptophan in human subjects. , 1975, British journal of clinical pharmacology.

[16]  R. Rajotte,et al.  A chronic conscious dog model for direct transhepatic studies in normal and pancreatic islet cell transplanted dogs. , 1991, Journal of Pharmacological Methods.