markedinhibitionofIFN-γandIgtranscription.Incontrast,inhibitionofAPRILandBLySinaggregateand diffusesynovitisleftIglevelsunaffectedandenhancedIFN-γproduction.Thesedifferentialimmunomodula- toryeffectscorrelatedwiththepresenceofTACI + Tcellsinaggregateanddiffusesynovitisandtheirabsence inGC + synoviti