Introduction to dielectrically modulated biological field effect transistor

In this embedded tutorial, a comprehensive account of dielectrically modulated biological field effect transistor (DM-BioFET) has been presented. The tutorial offers a general overview on BioFET, indicating the underlying physics of charge-modulated and dielectric-modulated transduction mechanism. Next, gradual developments in DM-BioFET have been discussed, and the effects of device downscaling on transduction performance has been typically emphasized. Subsequently, different DM-BioFET designs for transducer performance optimization has been analyzed from their device electrostatics and carrier transport mechanism. The comparative merits/ demerits of such emerging variants of DM-BioFET are also indicated in this context. In essence, the tutorial attempted to convey a clear understanding of DM-BioFET based biosensors for general readers, and the present research scenario, future promises as well as research challenges of this domain are duly elaborated for interested researchers.

[1]  Anuj Dhawan,et al.  Dielectric-Modulated Field Effect Transistors for DNA Detection: Impact of DNA Orientation , 2016, IEEE Electron Device Letters.

[2]  Jin-Woo Han,et al.  Analytical Modeling of a Nanogap-Embedded FET for Application as a Biosensor , 2010, IEEE Transactions on Electron Devices.

[3]  S. Chattopadhyay,et al.  Study and Analysis of the Effects of SiGe Source and Pocket-Doped Channel on Sensing Performance of Dielectrically Modulated Tunnel FET-Based Biosensors , 2016, IEEE Transactions on Electron Devices.

[4]  M. Schöning,et al.  Recent advances in biologically sensitive field-effect transistors (BioFETs). , 2002, The Analyst.

[5]  Denis Flandre,et al.  Direct protein detection with a nano-interdigitated array gate MOSFET. , 2009, Biosensors & bioelectronics.

[6]  D. Sharma,et al.  Performance comparison of single and dual metal dielectrically modulated TFETs for the application of label free biosensor , 2017 .

[7]  Jin-Woo Han,et al.  Development of a Point-of-Care Testing Platform With a Nanogap-Embedded Separated Double-Gate Field Effect Transistor Array and Its Readout System for Detection of Avian Influenza , 2011, IEEE Sensors Journal.

[8]  Cheulhee Jung,et al.  Novel dielectric-modulated field-effect transistor for label-free DNA detection , 2008 .

[9]  M. Saxena,et al.  Numerical Model of Gate-All-Around MOSFET With Vacuum Gate Dielectric for Biomolecule Detection , 2012, IEEE Electron Device Letters.

[10]  C. Sarkar,et al.  Novel charge plasma based dielectric modulated impact ionization MOSFET as a biosensor for label-free detection , 2015 .

[11]  Khalil Tamersit,et al.  Double-Gate Graphene Nanoribbon Field-Effect Transistor for DNA and Gas Sensing Applications: Simulation Study and Sensitivity Analysis , 2016, IEEE Sensors Journal.

[12]  R. Narang,et al.  Comparative Analysis of Dielectric-Modulated FET and TFET-Based Biosensor , 2015, IEEE Transactions on Nanotechnology.

[13]  Jinhuai Liu,et al.  Electrical nanogap devices for biosensing , 2010 .

[14]  Anthony Turner,et al.  Biosensors: Sense and Sensibility , 2013 .

[15]  Wendong Zhang,et al.  Progress of new label-free techniques for biosensors: a review , 2015, Critical reviews in biotechnology.

[16]  S. Ingebrandt,et al.  Biologically sensitive field-effect transistors: from ISFETs to NanoFETs , 2016, Essays in biochemistry.

[17]  James P Chambers,et al.  Biosensor recognition elements. , 2008, Current issues in molecular biology.

[18]  Kotaro Kajikawa,et al.  Label and Label-Free Detection Techniques for Protein Microarrays , 2015, Microarrays.

[19]  Ehsanur Rahman,et al.  Quantum ballistic analysis of transition metal dichalcogenides based double gate junctionless field effect transistor and its application in nano-biosensor , 2017 .

[20]  Sungho Kim,et al.  Dielectric Detection Using Biochemical Assays , 2013 .

[21]  D. Sharma,et al.  A dielectrically modulated electrically doped tunnel FET for application of label free biosensor , 2017 .

[22]  Pedro V. Baptista,et al.  Field Effect Sensors for Nucleic Acid Detection: Recent Advances and Future Perspectives , 2015, Sensors.

[23]  Zahra Ahangari Performance assessment of dual material gate dielectric modulated nanowire junctionless MOSFET for ultrasensitive detection of biomolecules , 2016 .

[24]  A. Kranti,et al.  Enhanced sensitivity of double gate junctionless transistor architecture for biosensing applications , 2015, Nanotechnology.

[25]  Shivendra Yadav,et al.  Comparative analysis of full-gate and short-gate dielectric modulated electrically doped Tunnel-FET based biosensors , 2017 .

[26]  G. S. Wilson,et al.  Electrochemical biosensors: recommended definitions and classification. , 2001, Biosensors & bioelectronics.

[27]  Yang‐Kyu Choi,et al.  Improvement of Sensitivity and Limit of Detection in a Nanogap Biosensor by Controlling Surface Wettability , 2013 .

[28]  M. Jagadesh Kumar,et al.  Dielectric-Modulated Impact-Ionization MOS Transistor as a Label-Free Biosensor , 2013, IEEE Electron Device Letters.

[29]  LABEL-FREE ELECTRICAL DETECTION OF PSA BY A NANOGAP FIELD EFFECT TRANSISTOR , 2008 .

[30]  Dheeraj Sharma,et al.  A Charge-Plasma-Based Dielectric-Modulated Junctionless TFET for Biosensor Label-Free Detection , 2017, IEEE Transactions on Electron Devices.

[31]  M. J. Kumar,et al.  Dielectric modulated overlapping gate-on-drain tunnel-FET as a label-free biosensor , 2015 .

[32]  S. A. Mondal,et al.  Design and Investigation on Bioinverter and Bioring-Oscillator for Dielectrically Modulated Biosensing Applications , 2017, IEEE Transactions on Nanotechnology.

[33]  P. Kondekar,et al.  Label-free biosensor using nanogap embedded dielectric modulated schottky tunneling source impact ionization MOS , 2016 .

[34]  Ajay,et al.  Investigation of dielectric modulated (DM) double gate (DG) junctionless MOSFETs for application as a biosensors , 2015 .

[35]  P. Bergveld,et al.  ISFET based enzyme sensors. , 1987, Biosensors.

[36]  Hafizur Rahaman,et al.  Investigating the performance of Short Gate Insulator Less Dielectrically Modulated Tunnel Field Effect Transistor based bio-sensors , 2015, 2015 6th International Conference on Computers and Devices for Communication (CODEC).

[37]  P Bergveld,et al.  A new approach to immunoFET operation. , 1990, Biosensors & bioelectronics.

[38]  Bonsang Gu,et al.  A dielectric-modulated field-effect transistor for biosensing. , 2007, Nature nanotechnology.

[39]  Wei Cao,et al.  Graphene and beyond-graphene 2D crystals for next-generation green electronics , 2014, Defense + Security Symposium.

[40]  Shivendra Yadav,et al.  Performance Assessment of A Novel Vertical Dielectrically Modulated TFET-Based Biosensor , 2017, IEEE Transactions on Electron Devices.

[41]  Sang Yup Lee,et al.  An Underlap Channel-Embedded Field-Effect Transistor for Biosensor Application in Watery and Dry Environment , 2012, IEEE Transactions on Nanotechnology.

[42]  Sang Kyu Kim,et al.  Ion-Sensitive Field-Effect Transistor for Biological Sensing , 2009, Sensors.

[43]  G. S. Wilson,et al.  Electrochemical Biosensors: Recommended Definitions and Classification , 1999, Biosensors & bioelectronics.

[44]  S. Chattopadhyay,et al.  A Device Simulation-Based Investigation on Dielectrically Modulated Fringing Field-Effect Transistor for Biosensing Applications , 2017, IEEE Sensors Journal.

[45]  M. Saxena,et al.  Dielectric Modulated Tunnel Field-Effect Transistor—A Biomolecule Sensor , 2012, IEEE Electron Device Letters.

[46]  Ehsanur Rahman,et al.  Effect of biomolecule position and fill in factor on sensitivity of a Dielectric Modulated Double Gate Junctionless MOSFET biosensor , 2017 .

[47]  Sang Yup Lee,et al.  Nanogap field-effect transistor biosensors for electrical detection of avian influenza. , 2009, Small.