Transglutaminase down‐regulates the dimerization of epidermal growth factor receptor in rat perivenous and periportal hepatocytes

Objective:  Recently, we found that transglutaminase 2 (TG2) might be involved in the difference in proliferative capacities between periportal hepatocytes (PPH) and perivenous hepatocytes (PVH) through down‐regulation of high‐affinity epidermal growth factor receptor (EGFR). However, it is uncertain whether this high‐affinity EGFR contributes to the hepatocyte growth signalling pathway. Here, we have investigated the influence of TG2 on EGF‐induced EGFR dimerization and its phosphorylation, which are important steps in the hepatocyte proliferative/growth signalling pathway, in PPH and PVH.

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