Hypervariable ‘minisatellite’ regions in human DNA

The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–15-base pair ‘core’ sequence similar to the generalized recombination signal (χ) of Escherichia coli. Many minisatellites are highly polymorphic due to allelic variation in repeat copy number in the minisatellite. A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.

[1]  A. Young,et al.  A polymorphic DNA marker genetically linked to Huntington's disease , 1983, Nature.

[2]  A. Jeffreys,et al.  Linkage of adult α- and β-globin genes in X. laevis and gene duplication by tetraploidization , 1980, Cell.

[3]  A. Jeffreys.  DNA sequence variants in the G γ-, A γ-, δ- and β-globin genes of man , 1979, Cell.

[4]  C. Kurz,et al.  A colorimetric method for DNA hybridization. , 1984, Nucleic acids research.

[5]  N. Morton.  Outline of Genetic Epidemiology , 1982 .

[6]  C. Thomas White,et al.  The diagonal-traverse homology search algorithm for locating similarities between two sequences , 1984, Nucleic Acids Res..

[7]  W. Rutter,et al.  The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences , 1982, Nature.

[8]  K. Davies,et al.  Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy , 1982, Nature.

[9]  G. Dover,et al.  Molecular drive: a cohesive mode of species evolution , 1982, Nature.

[10]  W. Ewens.  Mathematical Population Genetics , 1980 .

[11]  D. Weatherall.  The new genetics and clinical practice , 1982 .

[12]  E. Chen,et al.  Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue , 1983, Nature.

[13]  A. Jeffreys,et al.  Organization of the human myoglobin gene. , 1984, The EMBO journal.

[14]  J. Vieira,et al.  The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. , 1982, Gene.

[15]  R. White,et al.  A highly polymorphic locus in human DNA. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[16]  G. Hong,et al.  Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[17]  W. Gilbert,et al.  Sequencing end-labeled DNA with base-specific chemical cleavages. , 1980, Methods in enzymology.

[18]  W. Ewens,et al.  Estimation of genetic variation at the DNA level from restriction endonuclease data. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[19]  P. Chambon,et al.  A reliable method for the recovery of DNA fragments from agarose and acrylamide gels. , 1981, Analytical biochemistry.

[20]  S. Orkin,et al.  Development of homozygosity for chromosome 11p markers in Wilms' tumour , 1984, Nature.

[21]  A. Feinberg,et al.  Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours , 1984, Nature.

[22]  W. J. Brammar,et al.  A bacteriophage lambda vector for cloning large DNA fragments made with several restriction enzymes. , 1980, Gene.

[23]  Gerald R. Smith.  Chi hotspots of generalized recombination , 1983, Cell.

[24]  F. Sanger,et al.  DNA sequencing with chain-terminating inhibitors. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[25]  D. Barker,et al.  Restriction sites containing CpG show a higher frequency of polymorphism in human DNA , 1984, Cell.

[26]  S. Kunes,et al.  Structure of chi hotspots of generalized recombination , 1981, Cell.

[27]  T. P. Dryja,et al.  Expression of recessive alleles by chromosomal mechanisms in retinoblastoma , 1983, Nature.

[28]  G. Hong,et al.  Rapid synthesis of oligodeoxyribonucleotides VI. Efficient, mechanised synthesis of heptadecadeoxyribonucleotides by an improved solid phase phosphotriester route. , 1981, Nucleic acids research.

[29]  J. Vieira,et al.  A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. , 1982, Gene.

[30]  D. Botstein,et al.  Construction of a genetic linkage map in man using restriction fragment length polymorphisms. , 1980, American journal of human genetics.

[31]  W. Ewens.  The sampling theory of selectively neutral alleles. , 1972, Theoretical population biology.

[32]  S. Goodbourn,et al.  Highly variable regions of DNA flank the human alpha globin genes. , 1981, Nucleic acids research.

[33]  K. Davies,et al.  Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[34]  N. Copeland,et al.  Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour , 1984, Nature.

[35]  E. Southern.  Gel electrophoresis of restriction fragments. , 1979, Methods in enzymology.

[36]  T. Maniatis,et al.  The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene , 1982, Cell.

[37]  S. Goodbourn,et al.  Molecular basis of length polymorphism in the human zeta-globin gene complex. , 1983, Proceedings of the National Academy of Sciences of the United States of America.