Antimicrobial activity of crude and semi-purified fractions of Warburgia ugandensis against some pathogens

The medicinal quality of plants has been known and exploited by man for centuries. A large number of modern drugs have been isolated from traditional herbal plants[1]. Numerous secondary metabolites obtained from plants, with previously unknown pharmacological activities, have been extensively investigated as a source of medicinal agents[1,2]. The acceptance of traditional medicine as an alternative form of health care and the development of microbial resistance to the available antibiotics led to investigation on the antimicrobial activity of medicinal plants. The increasing failure of chemotherapeutics and antibiotic resistance exhibited by pathogenic agents has led to the screening of several PEER REVIEW ABSTRACT

[1]  Yujiong Wang,et al.  Azithromycin Synergistically Enhances Anti-Proliferative Activity of Vincristine in Cervical and Gastric Cancer Cells , 2012, Cancers.

[2]  V. K. Mishra,et al.  Biodiversity Status in Ethiopia and Challenges , 2012 .

[3]  V. K. Mishra,et al.  Medicinal Uses of Chlorophyll: a critical overview , 2012 .

[4]  E. Ateka,et al.  7α-Acetylugandensolide and antimicrobial properties of Warburgia ugandensis extracts and isolates against sweet potato pathogens , 2011 .

[5]  P. Damme,et al.  Antimicrobial and antioxidative effects of Ugandan medicinal barks , 2011 .

[6]  S. Croft,et al.  Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro , 2010, Phytotherapy research : PTR.

[7]  G. Njoroge,et al.  Utilisation of priority traditional medicinal plants and local people's knowledge on their conservation status in arid lands of Kenya (Mwingi District) , 2010, Journal of ethnobiology and ethnomedicine.

[8]  P. Were,et al.  Prophylactic and curative activities of extracts from Warburgia ugandensis Sprague (Canellaceae) and Zanthoxylum usambarense (Engl.) Kokwaro (Rutaceae) against Plasmodium knowlesi and Plasmodium berghei. , 2010, Journal of ethnopharmacology.

[9]  E. Figueiredo,et al.  Digoxin's roles in heart failure patients An overview , 2010 .

[10]  A. Wanjoya,et al.  In vitro effects of Warburgia ugandensis, Psiadia punctulata and Chasmanthera dependens on Leishmania major promastigotes. , 2010, African journal of traditional, complementary, and alternative medicines : AJTCAM.

[11]  P. Erasto,et al.  Antimicrobial and cytotoxic activities of fresh leaf extracts of Warburgia ugandensis , 2009 .

[12]  L. Downsborough,et al.  Conservation, commercialisation and confusion: harvesting of Ischyrolepis in a coastal forest, South Africa , 2009 .

[13]  B. P. Nautiyal,et al.  In vitro antileishmanial activity of extracts of Warburgia ugandensis (Canellaceae), a Kenyan medicinal plant , 2009 .

[14]  F. I. Abdulrahman,et al.  Phytochemical Composition and in Vitro Antimicrobial Investigation of Partition Fractions of the Crude Methanolic Extract of the Stembark of Croton Zambesicus , 2009 .

[15]  R. Mehta,et al.  Antiviral activity of phytochemicals: a comprehensive review. , 2008, Mini reviews in medicinal chemistry.

[16]  P. Ndalut,et al.  Evaluation of natural products as possible alternatives to methyl bromide in soil fumigation , 2006 .

[17]  S. Gibbons,et al.  Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity. , 2005, Phytochemistry.

[18]  D. Abebe,et al.  Screening of some medicinal plants of Ethiopia for their anti-microbial properties and chemical profiles. , 2005, Journal of ethnopharmacology.

[19]  D. Olila,et al.  Antibacterial and antifungal activities of extracts of Zanthoxylum chalybeum and Warburgia ugandensis, Ugandan medicinal plants. , 2001, African health sciences.