Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling.

[1]  D. Wedlich,et al.  Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. , 2007, Developmental cell.

[2]  O. MacDougald,et al.  Regulation of bone mass by Wnt signaling. , 2006, The Journal of clinical investigation.

[3]  E. Vellenga,et al.  Inhibition of the Transforming Growth Factor β (TGFβ) Pathway by Interleukin-1β Is Mediated through TGFβ-activated Kinase 1 Phosphorylation of SMAD3 , 2005 .

[4]  Stefan Mundlos,et al.  Modulation of GDF5/BRI‐b signalling through interaction with the tyrosine kinase receptor Ror2 , 2004, Genes to cells : devoted to molecular & cellular mechanisms.

[5]  T. Takumi,et al.  The Receptor Tyrosine Kinase Ror2 Associates with and Is Activated by Casein Kinase Iϵ* , 2004, Journal of Biological Chemistry.

[6]  Zhijian J. Chen,et al.  TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. , 2004, Molecular cell.

[7]  H. Korswagen,et al.  Wnt Activates the Tak1/Nemo-like Kinase Pathway* , 2004, Journal of Biological Chemistry.

[8]  W. Forrester,et al.  Functional analysis of the domains of the C elegans Ror receptor tyrosine kinase CAM-1. , 2003, Developmental biology.

[9]  T. Komori,et al.  The Receptor Tyrosine Kinase Ror2 Associates with the Melanoma-associated Antigen (MAGE) Family Protein Dlxin-1 and Regulates Its Intracellular Distribution* , 2003, Journal of Biological Chemistry.

[10]  Nobuyuki Onishi,et al.  The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway , 2003, Genes to cells : devoted to molecular & cellular mechanisms.

[11]  Hans Clevers,et al.  Caught up in a Wnt storm: Wnt signaling in cancer. , 2003, Biochimica et biophysica acta.

[12]  Naoto Ueno,et al.  The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/β-Catenin Signaling , 2003, Molecular and Cellular Biology.

[13]  I. Hiratani,et al.  The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. , 2002, Development.

[14]  H. Clevers,et al.  The many faces of the tumor suppressor gene APC. , 2001, Experimental cell research.

[15]  J W Yates,et al.  Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. , 2000, Chemistry & biology.

[16]  S. Mundlos,et al.  Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B. , 2000, American journal of human genetics.

[17]  M. Patton,et al.  Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2 , 2000, Nature Genetics.

[18]  P. Polakis Wnt signaling and cancer. , 2000, Genes & development.

[19]  M. Peifer,et al.  Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus. , 2000, Science.

[20]  G. Yancopoulos,et al.  Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development , 2000, Nature Genetics.

[21]  G. Yancopoulos,et al.  Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B , 2000, Nature Genetics.

[22]  S. Akira,et al.  Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation , 2000, Genes to cells : devoted to molecular & cellular mechanisms.

[23]  Randall T Moon,et al.  Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways , 1999, Oncogene.

[24]  E. Perens,et al.  A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division , 1999, Nature.

[25]  L. Nelles,et al.  SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes* , 1999, The Journal of Biological Chemistry.

[26]  Hans Clevers,et al.  The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF , 1999, Nature.

[27]  Wei Yang,et al.  Expression and genetic analysis of prtb, a gene that encodes a highly conserved proline‐rich protein expressed in the brain , 1999, Developmental dynamics : an official publication of the American Association of Anatomists.

[28]  R. Grosschedl,et al.  Regulation of LEF-1/TCF transcription factors by Wnt and other signals. , 1999, Current opinion in cell biology.

[29]  A. Hoffmann,et al.  Bmp‐2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T½) , 1998, Developmental dynamics : an official publication of the American Association of Anatomists.

[30]  G. Gross,et al.  Parathyroid Hormone Enhances Early and Suppresses Late Stages of Osteogenic and Chondrogenic Development in a BMP‐Dependent Mesenchymal Differentiation System (C3H10T½) , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[31]  K. Irie,et al.  TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase* , 1997, The Journal of Biological Chemistry.

[32]  P. Polakis,et al.  Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein , 1996, Molecular and cellular biology.

[33]  K. Irie,et al.  A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3* , 1996, The Journal of Biological Chemistry.

[34]  K. Irie,et al.  TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction , 1996, Science.

[35]  K. Irie,et al.  Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction , 1995, Science.

[36]  G. Gross,et al.  Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages. , 1993, DNA and cell biology.

[37]  G. Stein,et al.  Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix , 1990, Journal of cellular physiology.

[38]  Dmitry Vasunin,et al.  Additional Figures , 1964 .

[39]  P. Bodine,et al.  The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. , 2005, Molecular endocrinology.

[40]  C. Rubin,et al.  Proline‐rich transcript of the brain (prtb) is a serum‐responsive gene in osteoblasts and upregulated during adhesion , 2002, Journal of cellular biochemistry.