Cellular and biomolecular recognition : synthetic and non-biological molecules

DEVELOPMENT OF FUNCTIONAL MATERIALS FROM ROD-LIKE VIRUSES Introduction Overview Programmable Protein Shells Templated Syntheses of Composite Materials Self-Assembly of Rod-Like Viruses Virus-Based Device and Applications Outlook BIOMIMETIC NANOPARTICLES PROVIDING MOLECULARLY DEFINED BINDING SITES ? PROTEIN-FEATURING STRUCTURES VERSUS MOLECULARLY IMPRINTED POLYMERS Introduction Core Materials and Functionalities Functional Shells Applications Products Conclusions INTERACTION BETWEEN SILICA PARTICLES AND HUMAN EPITHELIAL CELLS: ATOMIC FORCE MICROSCOPY AND FLUORESCENCE STUDY Interaction of Silica with Biological Cells: Background Interaction of Silica Particle with the Cell Surface: How it is Seen with AFM Ultra-Bright Fluorescent Silica Particles to be Used to Study Interaction with Cells Ultra-Bright Fluorescent Silica Particles to Distinguish Between Cancer and Normal Cells CHIRAL MOLECULAR IMPRINTING AS A TOOL FOR DRUG SENSING Introduction Electrochemical Drug Sensors Optical Drug Sensors Mass Drug Sensors CATALYTIC ANTIBODIES FOR SELECTIVE CANCER CHEMOTHERAPY Introduction Catalytic Antibodies Designed for Prodrug Activation Catalytic Antibody 38C2 and Cancer Therapy Chemically Programmed Antibodies NATURAL AND SYNTHETIC STIMULATORS OF THE IMMUNE RESPONSE Introduction Lipopolysaccharide Endotoxin ? A Potent Immunostimulatory Molecule LPS Recognition Septic Shock LPS Biosynthesis Minimal Modified Lipid A Isolation of ?Natural? Kdo2-Lipid A Synthetic LPS, Lipid A and Their Uses Structural Studies Bacterial LPS-Binding Proteins Sphingolipids ? Essential Membrane Components of Mammals, Plants, Fungi, Yeast and Bacteria Natural Killer T Cells and GSLs GSL Antigens Structure ? Activity Relationships Saccharide Modification Ceramide Modification High-Resolution Structural Analysis of Receptor-GSL Complexes SUPRAMOLECULAR ASSEMBLIES OF POLYDIACETYLENES FOR BIOMOLECULAR SENSING: COLORIMETRIC AND ?TURN-ON? FLUORESCENCE APPROACHES Introduction Vesicular PDA Sensors for Colorimetric Signaling of Bacterial Pore-Forming Toxin Fabrication of ?Turn-On? Fluorescence Vesicle Sensors with PDAs ?Mix-and-Detect? Type of ?Turn-On? Fluorescence Sensor for Bacterial Toxin MULTIVALENT SYNTHETIC RECEPTORS FOR PROTEINS Aminopyrazoles for Beta-Sheet Capping in Protein Misfolding Events New Mechanisms of Enzyme Inhibition by Molecular Clips and Tweezers Protein Surface Recognition by Tailor-Made Polymers ANALYSIS OF BIOLOGICAL INTERACTIONS AND RECOGNITIONS BY SURFACE PLASMON RESONANCE Introduction to Surface Plasmon Resonance Technology Working Principle of SPR Sensor Surface Chemistry and Its Fabrications Important Factors Impacting on the Performance of SPR-Based Analyses of Biological Interactions on the Nonbiological Transducer Surface Localized SPR of Inorganic Nanoparticles for Analyses of Biological Interaction MEMBRANE-ACTIVE NATURAL AND SYNTHETIC PEPTIDES AND PEPTIDOMIMETICS Introduction Mode of Action of Membrane-Active Peptides Natural Peptides Synthetic Peptides Peptidomimetics LUMINESCENT QUANTUM DOT FLUORESCENCE RESONANCE ENERGY TRANSFER-BASED PROBES IN CELLULAR AND BIOLOGICAL ASSAYS Introduction Luminescent QDs FRET QD FRET-Based Protease Probes NEW PROTEINS FOR NEW SENSING METHODOLOGIES: THE CASE OF THE PROTEIN-BINDING FAMILY Introduction Galactose/Glucose-Binding Protein from Escherichia Coli Glutamine-Binding Protein from E. Coli Trehalose/Maltose-Binding Protein from the Hyperthermophilic Archaeon Thermococcus Litoralis Lipocalins and Odorant-Binding Protein METHODS OF ANALYSIS FOR IMAGING AND DETECTING IONS AND MOLECULES Fluorescent and Luminescent Proteins Functional Peptides Representative Technologies for Molecular Imaging