Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson’s disease
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N. Hattori | H. Yoshino | Y. Imai | M. Funayama | T. Tsunemi | Kahori Shiba-Fukushima | Yuanzhe Li | K. Nishioka | J. Ogata | Y. Oji | Tomoyo Shimada | D. Taniguchi | A. Ikeda | Toshiki Tezuka | Mariko Sano
[1] T. Dawson,et al. Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease , 2022, Movement disorders : official journal of the Movement Disorder Society.
[2] M. Kameyama,et al. Autopsy Validation of the Diagnostic Accuracy of 123I-Metaiodobenzylguanidine Myocardial Scintigraphy for Lewy Body Disease , 2022, Neurology.
[3] S. Park,et al. LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss , 2022, Cells.
[4] Yuki Yoshioka,et al. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation , 2021, Nature Communications.
[5] S. Knapp,et al. Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2 , 2021, bioRxiv.
[6] A. Myasnikov,et al. Structural analysis of the full-length human LRRK2 , 2021, Cell.
[7] Changhe Shi,et al. Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants , 2021, Annals of clinical and translational neurology.
[8] E. Tolosa,et al. R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils , 2021, Acta Neuropathologica.
[9] N. Murase,et al. The identified clinical features of Parkinson's disease in homo-, heterozygous and digenic variants of PINK1 , 2020, Neurobiology of Aging.
[10] D. Alessi,et al. Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites , 2020, bioRxiv.
[11] T. Gasser,et al. Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells , 2020, Nature Communications.
[12] Samara L. Reck-Peterson,et al. Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction , 2020, Nature.
[13] G. Oyama,et al. Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan , 2020, Journal of Human Genetics.
[14] Huanming Yang,et al. An atlas of the protein-coding genes in the human, pig, and mouse brain , 2020, Science.
[15] D. Alessi,et al. Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease , 2020, Current opinion in cell biology.
[16] E. Tolosa,et al. LRRK2 in Parkinson disease: challenges of clinical trials , 2020, Nature Reviews Neurology.
[17] Susan S. Taylor,et al. The In Situ Structure of Parkinson’s Disease-Linked LRRK2 , 2019, Cell.
[18] H. Okano,et al. Mutations in CHCHD2 cause α-synuclein aggregation. , 2019, Human molecular genetics.
[19] J. Trojanowski,et al. Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease , 2019, Acta Neuropathologica Communications.
[20] S. Pfeffer,et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins , 2019, bioRxiv.
[21] Luwen Wang,et al. RAB10 PHOSPHORYLATION IS A PROMINENT PATHOLOGICAL FEATURE IN ALZHEIMER’S DISEASE , 2019, Alzheimer's & Dementia.
[22] M. Cookson,et al. LRRK2 links genetic and sporadic Parkinson's disease. , 2019, Biochemical Society transactions.
[23] Gregor Bieri,et al. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons , 2019, bioRxiv.
[24] Susan S. Taylor,et al. Crystal structure of the WD40 domain dimer of LRRK2 , 2019, Proceedings of the National Academy of Sciences.
[25] N. Hattori,et al. Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations , 2018, Acta neuropathologica communications.
[26] E. Masliah,et al. LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation , 2018, Nature Communications.
[27] Xiaoling Liu,et al. The Association between LRRK2 G2385R and Phenotype of Parkinson's Disease in Asian Population: A Meta-Analysis of Comparative Studies , 2018, Parkinson's disease.
[28] Richard J Smeyne,et al. Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo , 2018, Brain : a journal of neurology.
[29] T. Gasser,et al. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils , 2017, The Biochemical journal.
[30] M. Islam,et al. G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain , 2018, Human molecular genetics.
[31] Matthias Mann,et al. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis , 2017, eLife.
[32] S. Schneider,et al. Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature , 2017, Movement disorders : official journal of the Movement Disorder Society.
[33] S. Chen,et al. Fatigue correlates with LRRK2 G2385R variant in Chinese Parkinson's disease patients. , 2017, Parkinsonism & related disorders.
[34] A. Dillman,et al. The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2. , 2017, The Biochemical journal.
[35] W. Seol,et al. G2385R and I2020T Mutations Increase LRRK2 GTPase Activity , 2016, BioMed research international.
[36] Matthias Mann,et al. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases , 2016, eLife.
[37] Ying Wang,et al. Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients , 2016, Aging and disease.
[38] E. Gerhardt,et al. LRRK2 Promotes Tau Accumulation, Aggregation and Release , 2015, Molecular Neurobiology.
[39] G. Deuschl,et al. MDS clinical diagnostic criteria for Parkinson's disease , 2015, Movement disorders : official journal of the Movement Disorder Society.
[40] Xiao-Guang Luo,et al. LRRK2 G2385R variant carriers of female Parkinson’s disease are more susceptible to motor fluctuation , 2013, Journal of Neurology.
[41] D. Mann,et al. Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain , 2013, Acta neuropathologica communications.
[42] K. Scearce-Levie,et al. Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations , 2012, Science Translational Medicine.
[43] M. Cookson,et al. The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation. , 2012, The Biochemical journal.
[44] N. Hattori,et al. LRRK2 I2020T mutation is associated with tau pathology. , 2012, Parkinsonism & related disorders.
[45] Mark Ellisman,et al. LRRK2 Parkinson disease mutations enhance its microtubule association. , 2011, Human molecular genetics.
[46] Charles Duyckaerts,et al. National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach , 2011, Acta Neuropathologica.
[47] E. Shin,et al. The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population. , 2010, Parkinsonism & related disorders.
[48] D. Petrey,et al. The WD40 Domain Is Required for LRRK2 Neurotoxicity , 2009, PLoS ONE.
[49] H. Takagi,et al. A meta-analysis of comparative studies of endovascular versus open repair for blunt thoracic aortic injury. , 2008, The Journal of thoracic and cardiovascular surgery.
[50] J. Burgunder,et al. LRRK2 Gly2385Arg variant is a risk factor of Parkinson’s disease among Han‐Chinese from mainland China , 2008, European journal of neurology.
[51] P. Barone,et al. Apoptotic mechanisms in mutant LRRK2-mediated cell death. , 2007, Human molecular genetics.
[52] M. Farrer,et al. Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia. , 2007, Parkinsonism & related disorders.
[53] N. Hattori,et al. Leucine-Rich Repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population , 2007, Neuroreport.
[54] Cao Li,et al. The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson's disease. , 2007, Movement disorders : official journal of the Movement Disorder Society.
[55] M. Farrer,et al. Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries , 2006, Movement disorders : official journal of the Movement Disorder Society.
[56] A. R.,et al. Review of literature , 1951, American Potato Journal.
[57] Thomas Meitinger,et al. Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology , 2004, Neuron.
[58] Andrew Lees,et al. Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease , 2004, Neuron.
[59] R. Wallace. Is this a practical approach? , 2001, Journal of the American College of Surgeons.