Human histologic evaluation of anorganic bovine bone mineral combined with recombinant human platelet-derived growth factor BB in maxillary sinus augmentation: case series study.

The objective of this proof-of-principle study was to examine the potential for improved bone regenerative outcomes in maxillary sinus augmentation procedures when recombinant human platelet-derived growth factor BB (0.3 mg/mL) is combined with particulate anorganic bovine bone mineral. The surgical outcomes in all treated sites were uneventful at 6 to 8 months, with sufficient regenerated bone present to allow successful placement of maxillary posterior implants. Large areas of dense, well-formed lamellar bone were seen throughout the intact core specimens in more than half of the grafted sites. Abundant numbers of osteoblasts were noted in concert with significant osteoid in all sites, indicating ongoing osteogenesis. A number of cores demonstrated efficient replacement of the normally slowly resorbing anorganic bovine bone mineral matrix particles with newly formed bone when the matrix was saturated with recombinant human platelet-derived growth factor BB.

[1]  D. Kim,et al.  Minimally invasive alveolar ridge augmentation procedure (tunneling technique) using rhPDGF-BB in combination with three matrices: a case series. , 2009, The International journal of periodontics & restorative dentistry.

[2]  D. Kim,et al.  Vertical ridge augmentation using an equine block infused with recombinant human platelet-derived growth factor-BB: a histologic study in a canine model. , 2009, The International journal of periodontics & restorative dentistry.

[3]  D. Kim,et al.  Human histologic evaluation of mineralized collagen bone substitute and recombinant platelet-derived growth factor-BB to create bone for implant placement in extraction socket defects at 4 and 6 months: a case series. , 2009, The International journal of periodontics & restorative dentistry.

[4]  S. Froum,et al.  Histomorphometric comparison of a biphasic bone ceramic to anorganic bovine bone for sinus augmentation: 6- to 8-month postsurgical assessment of vital bone formation. A pilot study. , 2008, The International journal of periodontics & restorative dentistry.

[5]  Hom-lay Wang,et al.  Long-term evaluation of implant survival in augmented sinuses: a case series. , 2008, The International journal of periodontics & restorative dentistry.

[6]  A. Piattelli,et al.  Anorganic bone matrix retrieved 14 years after a sinus augmentation procedure: a histologic and histomorphometric evaluation. , 2007, Journal of periodontology.

[7]  C. Dellavia,et al.  Three-dimensional ridge augmentation with xenograft and recombinant human platelet-derived growth factor-BB in humans: report of two cases. , 2007, The International journal of periodontics & restorative dentistry.

[8]  S. Froum,et al.  Comparison of mineralized cancellous bone allograft (Puros) and anorganic bovine bone matrix (Bio-Oss) for sinus augmentation: histomorphometry at 26 to 32 weeks after grafting. , 2006, The International journal of periodontics & restorative dentistry.

[9]  J. Fiorellini,et al.  Vertical ridge augmentation by means of deproteinized bovine bone block and recombinant human platelet-derived growth factor-BB: a histologic study in a dog model. , 2006, The International journal of periodontics & restorative dentistry.

[10]  I. Rhyu,et al.  Bone reaction to bovine hydroxyapatite for maxillary sinus floor augmentation: histologic results in humans. , 2006, The International journal of periodontics & restorative dentistry.

[11]  Hom-lay Wang,et al.  Histologic analyses of human mineralized bone grafting material in sinus elevation procedures: a case series. , 2006, The International journal of periodontics & restorative dentistry.

[12]  S. Froum,et al.  Sinus augmentation utilizing anorganic bovine bone (Bio-Oss) with absorbable and nonabsorbable membranes placed over the lateral window: histomorphometric and clinical analyses. , 2005, The International journal of periodontics & restorative dentistry.

[13]  J. Hatch,et al.  Histologic evaluation of mineralized and demineralized freeze-dried bone allograft for ridge and sinus augmentations. , 2005, The International journal of periodontics & restorative dentistry.

[14]  T. Testori,et al.  Systematic review of survival rates for implants placed in the grafted maxillary sinus. , 2004, The International journal of periodontics & restorative dentistry.

[15]  E. Burger,et al.  Histomorphometry of human sinus floor augmentation using a porous beta-tricalcium phosphate: a prospective study. , 2004, Clinical oral implants research.

[16]  Hans-Dieter John,et al.  Histomorphometric analysis of natural bone mineral for maxillary sinus augmentation. , 2004, The International journal of oral & maxillofacial implants.

[17]  S. Froum,et al.  Effect of maxillary sinus augmentation on the survival of endosseous dental implants. A systematic review. , 2003, Annals of periodontology.

[18]  P. Fugazzotto.  GBR using bovine bone matrix and resorbable and nonresorbable membranes. Part 1: histologic results. , 2003, The International journal of periodontics & restorative dentistry.

[19]  E. Burger,et al.  Deproteinized cancellous bovine bone (Bio-Oss) as bone substitute for sinus floor elevation. A retrospective, histomorphometrical study of five cases. , 2003, Journal of clinical periodontology.

[20]  Lars Sennerby,et al.  A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture. , 2002, The International journal of oral & maxillofacial implants.

[21]  David Yu.  Sinus Floor Elevation Using Anorganic Bovine Bone Matrix (OsteoGraf/N) With and Without Autogenous Bone: A Clinical, Histologic, Radiographic, and Histomorphometric Analysis—Part 2 of an Ongoing Prospective Study , 2002 .

[22]  G. Tawil,et al.  Sinus floor elevation using a bovine bone mineral (Bio-Oss) with or without the concomitant use of a bilayered collagen barrier (Bio-Gide): a clinical report of immediate and delayed implant placement. , 2001, The International journal of oral & maxillofacial implants.

[23]  A. Bolin,et al.  Reconstruction of severely resorbed alveolar ridge crests with dental implants using a bovine bone mineral for augmentation. , 2001, The International journal of oral & maxillofacial implants.

[24]  S. Froum,et al.  Histologic and clinical comparison of bilateral sinus floor elevations with and without barrier membrane placement in 12 patients: Part 3 of an ongoing prospective study. , 2000, The International journal of periodontics & restorative dentistry.

[25]  S. Lynch,et al.  Modification of an osteoconductive anorganic bovine bone mineral matrix with growth factors. , 1999, Journal of periodontology.

[26]  R. Genco,et al.  Tissue engineering : applications in maxillofacial surgery and periodontics , 1999 .

[27]  R. Kitazawa,et al.  Expression of platelet-derived growth factor proteins and their receptor alpha and beta mRNAs during fracture healing in the normal mouse. , 1999, Histochemistry and cell biology.

[28]  P. Valentini,et al.  Maxillary sinus floor elevation for implant placement with demineralized freeze-dried bone and bovine bone (Bio-Oss): a clinical study of 20 patients. , 1997, The International journal of periodontics & restorative dentistry.

[29]  A. Freemont,et al.  Platelet-derived growth factor expression in normally healing human fractures. , 1995, Bone.

[30]  S. Scully,et al.  Role of growth factors in fracture healing. , 1991, Progress in clinical and biological research.