Plasma exchange in six patients with advanced cancers of the head and neck

Six patients with advanced squamous cell cancers of the head and neck, with serum IgA ≤ 400 mg/dl and IgE ≥ 1000 IU/ml. underwent a trial of six 2‐liter plasma exchanges over a 2–3‐week period. Disease progressed in patients 1. 2. and 4. who died on days 44. 72. and 159. The tumor in patients 3 and 6 regressed significantly. repeatedly in patient 3 over each of four courses of apheresis. Tumor recurred in both patients after cessation of treatment, and they died at days 420 and 79. Patient 5. with inoperable disease, received full‐dose radiotherapy immediately following the course of apheresis. and showed complete response in the primary lesion and a major response in the extensive lymph node metastases, dying on day 421 of apparently unrelated causes. Serum IgE in the three patients experiencing tumor regression rose paradoxically during plasmapheresis. Only patient 3 had an elevated level of soluble E‐receptor suppressor factor prepheresis: the serum of patient 6 was lymphocytotoxic prepheresis but this activity decreased or disappeared during each of the exchanges studied. Controlled trials are now indicated.

[1]  R. Branda,et al.  Specific removal of antibodies with an immunoadsorption system , 1984, Transfusion.

[2]  A. Katz.  Immunobiologic Staging of Patients with Carcinoma of the Head and Neck , 1983, The Laryngoscope.

[3]  G. Unsgaard,et al.  Inhibitory effect on monocyte-mediated cytotoxicity of sera from patients with multiple myeloma and malignant lymphoma. , 2009, Scandinavian journal of haematology.

[4]  P. Boyle,et al.  Multiple‐site avascular necrosis A complication of Goodpasture's syndrome treated with plasma exchange and corticosteroids , 1982, The Medical journal of Australia.

[5]  G. C. Blanchard,et al.  A solid-phase fluoroimmunoassay for human IgE. , 1982, Journal of immunological methods.

[6]  M. Micksche,et al.  Plasmapheresis in patients with advanced malignant disease: a pilot study. , 1982, Oncology.

[7]  F. Moolten,et al.  Nonspecific immunosuppressive factors in malignant ascites: further characterization and possible relationship to erythrocyte receptors of human peripheral T cells. , 1981, Journal of immunology.

[8]  T. Yamamoto,et al.  Preliminary observations of the effects on breast adenocarcinoma of plasma perfused over immobilized protein A. , 1981, The New England journal of medicine.

[9]  P. Schuff-Werner,et al.  [Plasmapheresis: First clinical results in malignant tumors]. , 1981, Schweizerische medizinische Wochenschrift.

[10]  Å. Ahlberg,et al.  A procedure for removing high titer antibodies by extracorporeal protein-A-sepharose adsorption in hemophilia: substitution therapy and surgery in a patient with hemophilia B and antibodies , 1981 .

[11]  D. R. Cooper,et al.  Extracorporeal immunoadsorption of myeloma IgG and autoimmune antibodies: a clinically feasible modality of treatment. , 1980, Clinical and experimental immunology.

[12]  D. R. Cooper,et al.  Ex vivo removal of serum igg in a patient with colon carcinoma.Some biochemical, immunological and histological observations , 1978, Cancer.

[13]  C. Ford,et al.  TOTAL LYMPHOCYTE-COUNTS IN BREAST CANCER , 1978, The Lancet.

[14]  Yong-Wuk Lee,et al.  Squamous cell carcinoma of the tongue in a nine year renal transplant survivor. A case report with a discussion of the risk of development of epithelial carcinomas in renal transplant survivors , 1978, Cancer.

[15]  I. Green,et al.  Protein A from Staphylococcus aureus-a mitogen for human T lymphocytes and B lymphocytes but not L lymphocytes. , 1978, Journal of immunology.

[16]  P. Mannoni,et al.  Plasmapheresis in patients with disseminated cancer: Clinical results and correlation with changes in serum protein. The concept of “nonspecific blocking factors” , 1977, Cancer.

[17]  S. Weitzman,et al.  Impaired humoral immunity in treated Hodgkin's disease. , 1977, The New England journal of medicine.

[18]  J. Rosenbaum,et al.  The role of ige in the immune response to neoplasia: A review , 1977 .

[19]  P. Hersey,et al.  ANTIBODY-DEPENDENT, CELL-MEDIATED CYTOTOXICITY AGAINST MELANOMA CELLS INDUCED BY PLASMAPHERESIS , 1976, The Lancet.

[20]  P. Chretien,et al.  Correlation of tumor burden with in vitro lymphocyte reactivity and antibodies to herpesvirus tumor‐associated antigens in head and neck squamous carcinoma , 1976, Cancer.

[21]  E. Lally,et al.  The association of the IgA levels of serum and whole saliva with the progression of oral cancer , 1975, Cancer.

[22]  M. Mandel,et al.  Salivary immunoglobulins in patients with oropharyngeal and bronchopulmonary carcinoma , 1973, Cancer.

[23]  G. Currie,et al.  Serum Mediated Inhibition of the Immunological Reactions of the Patient to his Own Tumour: A Possible Role for Circulating Antigen , 1972, British Journal of Cancer.

[24]  I. Hellstrom,et al.  Suggestive evidence that the "blocking antibodies" of tumor-bearing individuals may be antigen--antibody complexes. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[25]  R. Morfin,et al.  Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. , 1970, Journal of lipid research.