A central osmosensitive receptor for renal sodium excretion.

1. The effect on renal Na and water excretion of increasing the NaCl concentration of blood supplying the brain was investigated in conscious water‐loaded sheep. Intracarotid infusion ot 4 M‐NACl at 0–8 ml./min for 60 min was compared with equivalent intrajugular infusion. 2. A more rapid increase in renal Na excretion and urine osmolality occurred with the intracarotid infusions than with intrajugular infusions. 3. Intracarotid infusions of 2 M sucrose or fructose at 1–6 ml./min for greater increase in renal Na excretion, urine osmolality and a decrease in urine flow rate. 4. The results suggest that there are receptors in the brain sensitive to changes in extracellular tonicity which influence renal Na excretion. It is possible that changes in ADH secretion alone mediate the early natriuresis seen with intracarotid hypertonic infusions although an alternative concurrent mechanism cannot be ruled out.

[1]  M. McKinley,et al.  Water drinking induced in sheep by angiotensin--a physiological or pharmacological effect? , 1975, Journal of comparative and physiological psychology.

[2]  J. McKenzie,et al.  Brain receptors, renin secretion, and renal sodium retention in conscious sheep. , 1974, American Journal of Physiology.

[3]  A. Rothballer,et al.  Forebrain lesion blockade of the natriuretic response to elevated carotid blood sodium. , 1973, Brain research.

[4]  A. Rothballer,et al.  Receptors in cerebral circulation affecting sodium excretion in the cat. , 1973, The American journal of physiology.

[5]  K. Olsson.  Further evidence for the importance of CSF Na+ concentration in central control of fluid balance. , 1973, Acta physiologica Scandinavica.

[6]  A. Rothballer,et al.  Essential hypernatremia. The experimental model. , 1973, Archives of neurology.

[7]  K. Olsson.  On the importance of CSF Na + concentration in central control of fluid balance. , 1972, Life sciences. Pt. 1: Physiology and pharmacology.

[8]  R. Gunther,et al.  Renal concentrating ability in sheep during urea, mannitol, and methylurea diuresis. , 1972, The American journal of physiology.

[9]  K. Olsson,et al.  Differences in the antidiuretic response to intracarotid infusions of various hypertonic solutions in the conscious goat. , 1971, Acta physiologica Scandinavica.

[10]  A. Nováková,et al.  Effect of posterior hypothalamic lesions on renal function in the rat. , 1971, Canadian journal of physiology and pharmacology.

[11]  K. Olsson,et al.  Lack of antidiuretic response to osmotic stimuli in the early stages of a water diuresis in sheep. , 1970, The Journal of endocrinology.

[12]  M. Humphreys,et al.  Natrriuresis produced by vasopressin or hemorrhage during water diuresis in the dog. , 1970, The American journal of physiology.

[13]  W. W. Moore,et al.  Effects of separate and concurrent osmotic and volume stimuli on plasma ADH in sheep. , 1970, The American journal of physiology.

[14]  J. C. Porter,et al.  Diencephalic involvement in sodium excretion in the rat. , 1970, Endocrinology.

[15]  O H Gauer,et al.  The regulation of extracellular fluid volume. , 1970, Annual review of physiology.

[16]  G. Kaley,et al.  Natriuresis Induced by Injection of Hypertonic Saline into the Third Cerebral Ventricle of Dogs∗ , 1969, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[17]  B. Andersson,et al.  Evidence for a hypothalamic control of renal sodium excretion. , 1969, Acta physiologica Scandinavica.

[18]  J. Perlmutt.  Contribution of carotid and vagal reflex mechanisms. , 1968, Federation proceedings.

[19]  W. Moran,et al.  Mechanisms of antidiuretic hormone (ADH) control of importance to the surgical patient. , 1967, Surgery.

[20]  W. V. Macfarlane,et al.  Vasopressins and the Increase of Water and Electrolyte Excretion by Sheep, Cattle and Camels , 1967, Nature.

[21]  M. Jobin,et al.  A study of thirst and other effects of an increased sodium concentration in the 3rd brain ventricle. , 1967, Acta physiologica Scandinavica.

[22]  D. Pleasure,et al.  Neurogenic hypernatremia. , 1966, Archives of neurology.

[23]  D. Denton,et al.  The effect of intracarotid infusions of 4‐M‐NaCl on the sodium drinking of sheep with a parotid fistula , 1965, The Journal of physiology.

[24]  C. W. Gottschalk.  OSMOTIC CONCENTRATION AND DILUTION OF THE URINE. , 1964, The American journal of medicine.

[25]  B. A. Baldwin,et al.  The anatomy of the cerebral circulation of the sheep and ox. The dynamic distribution of the blood supplied by the carotid and vertebral arteries to cranial regions. , 1963, Journal of anatomy.

[26]  V. Gubskii.  [THE EFFECT OF POSTERIOR PITUITARY HORMONES ON THE STIMULATED THYROID GLAND]. , 1963, Biulleten' eksperimental'noi biologii i meditsiny.

[27]  R. Keeler.  Effect of hypothalamic lesions on renal excretion of sodium. , 1959, The American journal of physiology.

[28]  M. Pickford,et al.  The effect of posterior pituitary hormones on the excretion of electrolytes, in dogs , 1958, The Journal of physiology.

[29]  J. Orloff,et al.  The effect of variations in solute excretion and vasopressin dosage on the excretion of water in the dog. , 1958, The Journal of clinical investigation.

[30]  L. Wesson,et al.  Some effects of pressor-antidiuretic and oxytocic fractions of posterior pituitary extract on sodium, chloride, potassium and ammonium excretion in the dog. , 1955, The American journal of physiology.

[31]  W. Sawyer.  Posterior pituitary extracts and excretion of electrolytes by the rat. , 1952, The American journal of physiology.

[32]  Verney Eb.  The antidiuretic hormone and the factors which determine its release. , 1947, Proceedings of the Royal Society of London. Series B, Biological sciences.

[33]  E. B. Verney,et al.  THE EFFECT OF REMOVAL OF THE POSTERIOR LOBE OF THE PITUITARY ON THE INHIBITION OF WATER‐DIURESIS BY EMOTIONAL STRESS , 1942 .