Synthesis and anti-inflammatory evaluation of 2-(substituted amino)quinolizinium bromides.

The synthesis and anti-inflammatory evaluation of a number of 2-(substituted amino)quinolizinium bromides, including some previously unreported analogs, are described. The more active compounds in inhibiting carrageenin-induced edema formation are those containing a p-alkoxyanilino group in the 2-position of the quinolizinium ring.