MRI-Guided Focused Ultrasound in Parkinson's Disease: A Review

MRI-guided focused ultrasound is a new technology that enables intracranial ablation. Since lesioning ameliorates some of the symptoms of PD, this technology is being explored as a possible treatment for medication resistant symptoms in PD patients. The purpose of this paper is to review the clinical use and treatment outcomes of PD patients treated to date with this technology.

[1]  Daniel Jeanmonod,et al.  First experience with MR-guided focused ultrasound in the treatment of Parkinson's disease , 2014, Journal of therapeutic ultrasound.

[2]  D. Goldsher,et al.  MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson's Disease , 2015, Parkinson's disease.

[3]  A. Haffenden,et al.  Referrals for Movement Disorder Surgery: Under-Representation of Females and Reasons for Refusal , 2006, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[4]  M. Zaaroor,et al.  A Trial of Focused Ultrasound Thalamotomy for Essential Tremor. , 2016, The New England journal of medicine.

[5]  G. Schaltenbrand,et al.  Atlas for Stereotaxy of the Human Brain , 1977 .

[6]  I. McKeith,et al.  SIC Task Force appraisal of clinical diagnostic criteria for parkinsonian disorders , 2003, Movement disorders : official journal of the Movement Disorder Society.

[7]  K. Kuroda,et al.  A precise and fast temperature mapping using water proton chemical shift , 1995, Magnetic resonance in medicine.

[8]  W. Dewey,et al.  Thermal dose determination in cancer therapy. , 1984, International journal of radiation oncology, biology, physics.

[9]  N. Wetzel.  SURGICAL TREATMENT OF PARKINSON'S DISEASE. , 1963, Chicago medicine.

[10]  W J FRY,et al.  Production of focal destructive lesions in the central nervous system with ultrasound. , 1954, Journal of neurosurgery.

[11]  K Hynynen,et al.  The potential of transskull ultrasound therapy and surgery using the maximum available skull surface area. , 1999, The Journal of the Acoustical Society of America.

[12]  F A Jolesz,et al.  Thermal dosimetry of a focused ultrasound beam in vivo by magnetic resonance imaging. , 1999, Medical physics.

[13]  M. Hallett,et al.  Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? , 2012, Brain : a journal of neurology.

[14]  Alon Sinai,et al.  Magnetic resonance-guided focused ultrasound thalamotomy for tremor: a report of 30 Parkinson's disease and essential tremor cases. , 2018, Journal of neurosurgery.

[15]  G. Deuschl,et al.  Neurostimulation for Parkinson's disease with early motor complications. , 2013, The New England journal of medicine.

[16]  I. Schlesinger,et al.  Relaxation guided imagery reduces motor fluctuations in Parkinson's disease. , 2014, Journal of Parkinson's disease.

[17]  G T Clement,et al.  A non-invasive method for focusing ultrasound through the human skull. , 2002, Physics in medicine and biology.

[18]  Jin Woo Chang,et al.  Factors associated with successful magnetic resonance-guided focused ultrasound treatment: efficiency of acoustic energy delivery through the skull. , 2016, Journal of neurosurgery.

[19]  M. Delong,et al.  Complications of gamma knife surgery for Parkinson disease. , 2001, Archives of neurology.

[20]  G. Deuschl,et al.  Tremors in Parkinson's Disease: Symptom Analysis and Rating , 1994, Clinical neuropharmacology.

[21]  J. Nutt,et al.  Motor fluctuations and dyskinesia in Parkinson's disease. , 2001, Parkinsonism & related disorders.

[22]  Benjamin L Walter,et al.  Surgical treatment for Parkinson's disease , 2004, The Lancet Neurology.

[23]  Young Cheol Na,et al.  Unilateral magnetic resonance–guided focused ultrasound pallidotomy for Parkinson disease , 2015, Neurology.

[24]  A. Lang,et al.  Pallidal and Thalamic Surgery for Parkinson's Disease , 1997, Experimental Neurology.

[25]  E. Moro,et al.  Gamma knife thalamotomy for disabling tremor: a blinded evaluation. , 2010, Archives of neurology.

[26]  R. Gwinn,et al.  132 A Randomized, Sham-Controlled Trial of Transcranial Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Trial for the Treatment of Tremor-Dominant, Idiopathic Parkinson Disease. , 2016, Neurosurgery.

[27]  W. Fry,et al.  Ultrasonic method of modifying brain st ructures. , 1962, Confinia neurologica.

[28]  J. Jankovic,et al.  Therapies in Parkinson's disease. , 2012, Current opinion in neurology.

[29]  S. Paek,et al.  Patients' reluctance to undergo deep brain stimulation for Parkinson's disease. , 2016, Parkinsonism & related disorders.

[30]  P. Fishman,et al.  Paradoxical aspects of parkinsonian tremor , 2008, Movement disorders : official journal of the Movement Disorder Society.

[31]  W. Fry,et al.  Early experiences with ultrasonic irradiation of the pallidofugal and nigral complexes in hyperkinetic and hypertonic disorders. , 1959, Journal of neurosurgery.

[32]  D. Calne,et al.  Early parkinsonism. , 1986, Clinical neuropharmacology.

[33]  R. Gregory.  SURGERY FOR MOVEMENT DISORDERS , 2002, Journal of neurology, neurosurgery, and psychiatry.