The Effect Of Candida Infections On Mortality Of ICU Patients: Results Of Sixty-Three Patients

Backgrounds: The aim of this study was to compare the fungal infections' mortality rates with other our ICU patients having fungal infections' risk factors and prolonged stay. Methods: We performed this retrospective, observational, comparative study on 63 ICU patients with Candida infection and 62 controls. The patients with Candida infection compared with controls for risk factors for fungal infections and mortality. Candida infections were composed of patients with candidemia and candiduria. We also compared candidemia/candiduria cases exclusively to the control group in respect to mortality and morbidity. Results: No statistically significant difference was established for mortality between candida group and controls (50.79 % and 48.38 % respectively, p=0.859). The mortality rates of candiduria and candidemia groups were also similar (46.66% versus 54.55%, p=0.617). When we compared with candidemia and controls for mortality rate, there was no statistically differences between them (54.55% versus 48.38, p=0.668). The mortality rate of the candiduria group was also similar to the controls (46.66% versus 48.38%, p=1). Conclusion: The severity of blood infections developed by Candida is well-known; however candiduria should not dismissed but managed more aggressively. We observed that candiduria had similar mortality rate to candidemia. This study was presented with preliminary data in 26 th International Symposium on Intensive Care and Emergency Medicine, Brussels, 2006.

[1]  C. d’Enfert,et al.  Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome , 2008, Intensive Care Medicine.

[2]  M. Falagas,et al.  Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies , 2006, European Journal of Clinical Microbiology and Infectious Diseases.

[3]  M. Bassetti,et al.  Epidemiological trends in nosocomial candidemia in intensive care , 2006, BMC infectious diseases.

[4]  Maria R R Silva,et al.  Candida colonization in intensive care unit patients' urine. , 2005, Memorias do Instituto Oswaldo Cruz.

[5]  J. L. Noble,et al.  Candidemia in intensive care unit patients: Risk factors for mortality , 2005, Infection.

[6]  A. Tortorano,et al.  Candidosis in the intensive care unit: a 20-year survey. , 2004, The Journal of hospital infection.

[7]  S. Akçağlar,et al.  Persistence of candiduria in ICU catheterized patients is not linked to adherence and proteolytic activities of Candida strains , 2004, Intensive Care Medicine.

[8]  R. Tufano,et al.  Candidemia in Intensive Care patients. Risk factors and mortality. , 2004, Minerva anestesiologica.

[9]  A. Bener,et al.  Epidemiology, presentation, management and outcome of candidemia in a tertiary care teaching hospital in the United Arab Emirates, 1995-2001. , 2003, Medical mycology.

[10]  A. Michalopoulos,et al.  Determinants of candidemia and candidemia-related death in cardiothoracic ICU patients. , 2003, Chest.

[11]  F. Alvarez-lerma,et al.  Candiduria in critically ill patients admitted to intensive care medical units , 2003, Intensive Care Medicine.

[12]  R. D. Gajdobranski,et al.  The role and importance of fungal infections in intensive care units, ICU , 2003 .

[13]  B. Draskovic,et al.  [Role and importance of fungal infections in intensive care units]. , 2003, Medicinski pregled.

[14]  F. Colardyn,et al.  Effects of nosocomial candidemia on outcomes of critically ill patients. , 2002, The American journal of medicine.

[15]  B. Guidet,et al.  Systemic candidiasis in intensive care units: a multicenter, matched-cohort study. , 2002, Journal of critical care.

[16]  R. Gaynes,et al.  Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[17]  R. Gaynes,et al.  Nosocomial Infections in Combined Medical-Surgical Intensive Care Units in the United States , 2000, Infection Control & Hospital Epidemiology.

[18]  Khatib,et al.  Clinicians’ reaction to positive urine culture for Candida organisms , 1999, Mycoses.

[19]  S. Fridkin,et al.  Epidemiology of nosocomial fungal infections , 1996, Clinical microbiology reviews.

[20]  M. Pfaller,et al.  Epidemiology of candidiasis. , 1995, The Journal of hospital infection.

[21]  J. M. Torres Rodríguez,et al.  [Candidiasis in an intensive care unit]. , 1993, Revista clinica espanola.

[22]  R F Woolson,et al.  Hospital-acquired candidemia. The attributable mortality and excess length of stay. , 1988, Archives of internal medicine.