C–H Bond Functionalization of Arylpyrimidines Catalyzed by an in situ Generated Ruthenium(II) Carboxylate System and the Construction of Tris(heteroaryl)‐Substituted Benzenes

A ruthenium(II) carboxylate catalyst, generated in situ from [RuCl 2 (p-cymene)] 2 and 1-phenyl-1-cyclopentanecarboxylic acid (PCCA) in the presence of K 2 CO 3 , allowed activation of the C―H bond in phenyl-substituted pyrimidines and their direct functionalization with both electron-deficient and electron-rich aryl halides. The scope of this process can be extended to the use of heteroaryl bromides and less reactive aryl chlorides. This Ru II -PCCA complex constitutes a better catalytic system in comparison to other carboxylates.

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