A computer model of myocardial disarray in simulating ECG features of hypertrophic cardiomyopathy.

Hypertrophic cardiomyopathy (HCM) was simulated with a computer heart model having a realistic shape and rotating fiber orientation in order to elucidate possible mechanisms for abnormal ECG findings. The disarray of myocardial muscle in HCM was simulated by assigning random fiber direction and isotropic electrophysiologic properties to abnormal hypertrophic regions, in contrast to the anisotropic modeling for normal myocardium. With these models, main ECG features including abnormal Q wave and QS pattern were reproduced and were comparable with clinical findings. This study suggests that the change in anisotropy in the hypertrophic myocardium is likely to be the main factor responsible to the ECG features of HCM.

[1]  J. Ross,et al.  Fiber Orientation in the Canine Left Ventricle during Diastole and Systole , 1969, Circulation research.

[2]  L. Clerc.  Directional differences of impulse spread in trabecular muscle from mammalian heart. , 1976, The Journal of physiology.

[3]  A. Goldberger.  Q wave T wave vector discordance in hypertrophic cardiomyopathy: septal hypertrophy and strain pattern. , 1979, British heart journal.

[4]  A. M. Scher,et al.  Influence of Cardiac Fiber Orientation on Wavefront Voltage, Conduction Velocity, and Tissue Resistivity in the Dog , 1979, Circulation research.

[5]  R. Bonow,et al.  Hypertrophic cardiomyopathy. , 1987, Disease-a-month : DM.

[6]  J. Gottdiener,et al.  Patterns and significance of distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy. A wide angle, two dimensional echocardiographic study of 125 patients. , 1981, The American journal of cardiology.

[7]  B. Maron,et al.  Relation of electrocardiographic abnormalities and patterns of left ventricular hypertrophy identified by 2-dimensional echocardiography in patients with hypertrophic cardiomyopathy. , 1983, The American journal of cardiology.

[8]  M. Davies.  The current status of myocardial disarray in hypertrophic cardiomyopathy. , 1984, British heart journal.

[9]  G. Schmidt,et al.  The Electromotive Force of the Ventricular Free Wall and Papillary Muscle Preparations , 1985, Circulation research.

[10]  Y Okamoto,et al.  Clinical application of electrocardiographic computer model. , 1989, Journal of electrocardiology.

[11]  Daming Wei,et al.  Comparative simulation of excitation and body surface electrocardiogram with isotropic and anisotropic computer heart models , 1995, IEEE Transactions on Biomedical Engineering.

[12]  S. Mashima.  Myocardial electrogenesis and the electrocardiogram. , 1999, Japanese heart journal.