Activity and structural dynamics of human ABCA1 in a lipid membrane.

[1]  E. Tajkhorshid,et al.  Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms , 2022, The EMBO journal.

[2]  W. S. Davidson,et al.  ABCA1 is an extracellular phospholipid translocase , 2022, Nature Communications.

[3]  Xiaochun Li,et al.  Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states , 2022, Nature Cardiovascular Research.

[4]  L. Molday,et al.  Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration , 2021, Progress in Retinal and Eye Research.

[5]  F. van Petegem,et al.  Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease , 2021, Nature Communications.

[6]  S. S.,et al.  Elucidating the Structural Features of ABCA1 in its Heterogeneous Membrane Environment , 2021, bioRxiv.

[7]  M. Liao,et al.  Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins , 2021, Nature Communications.

[8]  X. Gong,et al.  Structural basis of substrate recognition and translocation by human ABCA4 , 2021, Nature Communications.

[9]  Jue Chen,et al.  Molecular structures of the eukaryotic retinal importer ABCA4 , 2021, eLife.

[10]  M. Liao,et al.  The ABCs of Sterol Transport. , 2020, Annual review of physiology.

[11]  M. Liao,et al.  ABCG2 transports anticancer drugs via a closed-to-open switch , 2020, Nature Communications.

[12]  J. Smeitink,et al.  Brothers in Arms: ABCA1- and ABCG1-Mediated Cholesterol Efflux as Promising Targets in Cardiovascular Disease Treatment , 2019, Pharmacological Reviews.

[13]  M. Simon,et al.  Even Cancer Cells Watch Their Cholesterol! , 2019, Molecular cell.

[14]  R. Gaudet,et al.  Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters , 2019, Nature Structural & Molecular Biology.

[15]  K. Beis,et al.  Learning the ABCs one at a time: structure and mechanism of ABC transporters. , 2019, Biochemical Society transactions.

[16]  Erik Lindahl,et al.  New tools for automated high-resolution cryo-EM structure determination in RELION-3 , 2018, eLife.

[17]  B. Antonny,et al.  The Many Faces of Amphipathic Helices , 2018, Biomolecules.

[18]  K. Ueda,et al.  Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation , 2018, Scientific Reports.

[19]  M. Phillips Is ABCA1 a lipid transfer protein? , 2018, Journal of Lipid Research.

[20]  T. Walz,et al.  Structural basis of MsbA-mediated lipopolysaccharide transport , 2017, Nature.

[21]  X. Gong,et al.  Structure of the Human Lipid Exporter ABCA1 , 2017, Cell.

[22]  U. Hellmich,et al.  Diverse relations between ABC transporters and lipids: An overview. , 2017, Biochimica et biophysica acta. Biomembranes.

[23]  S. Hazen,et al.  PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly. , 2016, Circulation research.

[24]  M. Lindén,et al.  Anisotropic Membrane Curvature Sensing by Amphipathic Peptides. , 2014, Biophysical journal.

[25]  R. Marschalek,et al.  Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines. , 2015, Biotechnology journal.

[26]  E. Favari,et al.  Cholesterol efflux and reverse cholesterol transport. , 2015, Handbook of experimental pharmacology.

[27]  Toni Giorgino,et al.  MEMBPLUGIN: studying membrane complexity in VMD , 2014, Bioinform..

[28]  R. Molday,et al.  Differential Phospholipid Substrates and Directional Transport by ATP-binding Cassette Proteins ABCA1, ABCA7, and ABCA4 and Disease-causing Mutants*♦ , 2013, The Journal of Biological Chemistry.

[29]  S. Hazen,et al.  ABCA1 Mediates Unfolding of Apolipoprotein AI N Terminus on the Cell Surface Before Lipidation and Release of Nascent High-Density Lipoprotein , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[30]  A. Kusumi,et al.  ABCA1 dimer–monomer interconversion during HDL generation revealed by single-molecule imaging , 2013, Proceedings of the National Academy of Sciences.

[31]  N. Fitz,et al.  Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice , 2012, The Journal of Neuroscience.

[32]  Eric Gouaux,et al.  A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening. , 2012, Structure.

[33]  M. Hayden,et al.  Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT. , 2012, Biochimica et biophysica acta.

[34]  K. Ueda,et al.  ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding[S] , 2012, Journal of Lipid Research.

[35]  R. Bittman,et al.  A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol , 2011, Journal of Lipid Research.

[36]  D. Higgins,et al.  Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega , 2011, Molecular systems biology.

[37]  G. Voth,et al.  Mechanism of membrane curvature sensing by amphipathic helix containing proteins. , 2011, Biophysical journal.

[38]  E. Tajkhorshid,et al.  Conformational coupling of the nucleotide-binding and the transmembrane domains in ABC transporters. , 2009, Biophysical journal.

[39]  B. Fadeel,et al.  The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease , 2009, Critical reviews in biochemistry and molecular biology.

[40]  K. Ueda,et al.  Formation of Two Intramolecular Disulfide Bonds Is Necessary for ApoA-I-dependent Cholesterol Efflux Mediated by ABCA1* , 2009, Journal of Biological Chemistry.

[41]  A. Vaughan,et al.  ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation ** This work was supported by National Institutes of Health Grant RO1HL-55362. Published, JLR Papers in Press, September 5, 2008. , 2009, Journal of Lipid Research.

[42]  Andreas Engel,et al.  Structure and mechanics of membrane proteins. , 2008, Annual review of biochemistry.

[43]  A. Tall,et al.  HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis. , 2008, Cell metabolism.

[44]  G. Meer,et al.  Membrane lipids: where they are and how they behave , 2008, Nature Reviews Molecular Cell Biology.

[45]  Amy B. Ghering,et al.  ABCA1-Induced Cell Surface Binding Sites for ApoA-I , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[46]  A. Vaughan,et al.  ATP-binding Cassette Transporter A1 Expression Disrupts Raft Membrane Microdomains through Its ATPase-related Functions* , 2006, Journal of Biological Chemistry.

[47]  A. Vaughan,et al.  ATP-Binding cassette cholesterol transporters and cardiovascular disease. , 2006, Circulation research.

[48]  Elina Ikonen,et al.  Mechanisms for cellular cholesterol transport: defects and human disease. , 2006, Physiological reviews.

[49]  M. Phillips,et al.  Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I Published, JLR Papers in Press, January 17, 2006. , 2006, Journal of Lipid Research.

[50]  Paul Curnow,et al.  Membrane proteins, lipids and detergents: not just a soap opera. , 2004, Biochimica et biophysica acta.

[51]  A. Horwitz,et al.  ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I Published, JLR Papers in Press, January 1, 2004. DOI 10.1194/jlr.M300336-JLR200 , 2004, Journal of Lipid Research.

[52]  M. Freeman,et al.  ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux Published, JLR Papers in Press, November 16, 2003. DOI 10.1194/jlr.M300355-JLR200 , 2004, Journal of Lipid Research.

[53]  S. Yokoyama,et al.  Effects of Mutations of ABCA1 in the First Extracellular Domain on Subcellular Trafficking and ATP Binding/Hydrolysis* 210 , 2003, The Journal of Biological Chemistry.

[54]  A. von Eckardstein,et al.  The Central Helices of ApoA-I Can Promote ATP-binding Cassette Transporter A1 (ABCA1)-mediated Lipid Efflux , 2003, The Journal of Biological Chemistry.

[55]  S. Witting,et al.  The Role of Apolipoprotein A-I Helix 10 in Apolipoprotein-mediated Cholesterol Efflux via the ATP-binding Cassette Transporter ABCA1* , 2002, The Journal of Biological Chemistry.

[56]  M. Freeman,et al.  Naturally Occurring Mutations in the Largest Extracellular Loops of ABCA1 Can Disrupt Its Direct Interaction with Apolipoprotein A-I* , 2002, The Journal of Biological Chemistry.

[57]  J. Dietschy,et al.  Cholesterol metabolism in the brain , 2001, Current opinion in lipidology.

[58]  H. Rigneault,et al.  Specific Docking of Apolipoprotein A-I at the Cell Surface Requires a Functional ABCA1 Transporter* , 2001, The Journal of Biological Chemistry.

[59]  A. Rzhetsky,et al.  The human ATP-binding cassette (ABC) transporter superfamily. , 2001, Genome research.

[60]  R. Lawn,et al.  ABCA1 Is the cAMP-inducible Apolipoprotein Receptor That Mediates Cholesterol Secretion from Macrophages* , 2000, The Journal of Biological Chemistry.

[61]  A. Tall,et al.  Specific Binding of ApoA-I, Enhanced Cholesterol Efflux, and Altered Plasma Membrane Morphology in Cells Expressing ABC1* , 2000, The Journal of Biological Chemistry.

[62]  A. Vaughan,et al.  The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. , 1999, The Journal of clinical investigation.

[63]  T. Langmann,et al.  Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. , 1999, Biochemical and biophysical research communications.

[64]  K. Marheineke,et al.  Lipid composition of Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) insect cells used for baculovirus infection , 1998, FEBS letters.

[65]  F. Maxfield,et al.  Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. , 1998, Biophysical journal.

[66]  K Schulten,et al.  VMD: visual molecular dynamics. , 1996, Journal of molecular graphics.

[67]  F. Denizot,et al.  Cloning of two novel ABC transporters mapping on human chromosome 9. , 1994, Genomics.

[68]  A A Spector,et al.  Membrane lipid composition and cellular function. , 1985, Journal of lipid research.

[69]  W. Higuchi,et al.  Water solubility of cholesterol. , 1965, Journal of pharmaceutical sciences.