Emerging Technologies for Degenerative Disk Disease: Potential Synergy Between Biochemical Signaling and Spinal Biomechanics

[1]  Sudha Agarwal,et al.  Cyclic Tensile Stress Exerts a Protective Effect on Intervertebral Disc Cells , 2008, American journal of physical medicine & rehabilitation.

[2]  James D. Kang,et al.  Safety Assessment of Intradiscal Gene Therapy II: Effect of Dosing and Vector Choice , 2008, Spine.

[3]  L. Dai,et al.  Biologic Response of the Intervertebral Disc to Static and Dynamic Compression In Vitro , 2007, Spine.

[4]  A. Freemont,et al.  Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study , 2007, Arthritis research & therapy.

[5]  Lauren N. Smith,et al.  Regulation of Transgene Expression Using an Inducible System for Improved Safety of Intervertebral Disc Gene Therapy , 2007, Spine.

[6]  V. Vad,et al.  The role of the Back Rx exercise program in diskogenic low back pain: a prospective randomized trial. , 2007, Archives of physical medicine and rehabilitation.

[7]  K. Ando,et al.  Feasibility of Using a Human Nucleus Pulposus Cell Line as a Cell Source in Cell Transplantation Therapy for Intervertebral Disc Degeneration , 2006, Spine.

[8]  H. Baba,et al.  Effect of Mechanical Compression on the Lumbar Nerve Root: Localization and Changes of Intraradicular Inflammatory Cytokines, Nitric Oxide, and Cyclooxygenase , 2005, Spine.

[9]  L. Setton,et al.  Osmolarity Regulates Gene Expression in Intervertebral Disc Cells Determined by Gene Array and Real-Time Quantitative RT-PCR , 2005, Annals of Biomedical Engineering.

[10]  A. Freemont,et al.  The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration , 2005, Arthritis research & therapy.

[11]  W. Marras,et al.  Functional Impairment as a Predictor of Spine Loading , 2005, Spine.

[12]  Xiong Guo,et al.  Bone Mesenchymal Stem Cells Transplanted into Rabbit Intervertebral Discs Can Increase Proteoglycans , 2005, Clinical orthopaedics and related research.

[13]  E. Thonar,et al.  Intradiscal Administration of Osteogenic Protein-1 Increases Intervertebral Disc Height and Proteoglycan Content in the Nucleus Pulposus in Normal Adolescent Rabbits , 2005, Spine.

[14]  A. Freemont,et al.  Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc , 2004, The Journal of pathology.

[15]  Jeffrey C Lotz,et al.  Biological response of the intervertebral disc to dynamic loading. , 2004, Journal of biomechanics.

[16]  J. Rainville,et al.  Exercise as a treatment for chronic low back pain. , 2004, The spine journal : official journal of the North American Spine Society.

[17]  S. Roberts,et al.  Human intervertebral disc cell morphology and cytoskeletal composition: a preliminary study of regional variations in health and disease , 2003, Journal of anatomy.

[18]  W. Hutton,et al.  Disc Chondrocyte Transplantation in a Canine Model: A Treatment for Degenerated or Damaged Intervertebral Disc , 2003, Spine.

[19]  Lars G. Gilbertson,et al.  Gene Transfer of the Catabolic Inhibitor TIMP-1 Increases Measured Proteoglycans in Cells from Degenerated Human Intervertebral Discs , 2003, Spine.

[20]  Farshid Guilak,et al.  The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model. , 2003, Journal of biomechanical engineering.

[21]  Christoph Weiler,et al.  Classification of Age-Related Changes in Lumbar Intervertebral Discs: 2002 Volvo Award in Basic Science , 2002, Spine.

[22]  H. Seeherman,et al.  Retention of 125I‐labeled recombinant human bone morphogenetic protein‐2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[23]  N. Boos,et al.  2002 SSE Award Competition in Basic Science: Expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption , 2002, European Spine Journal.

[24]  B. Caterson,et al.  Matrix Metalloproteinases And Aggrecanase: Their Role in Disorders of the Human Intervertebral Disc , 2000, Spine.

[25]  T. Oegema,et al.  Fibronectin and Its Fragments Increase With Degeneration in the Human Intervertebral Disc , 2000, Spine.

[26]  J. Lotz,et al.  Intervertebral Disc Cell Death Is Dependent on the Magnitude and Duration of Spinal Loading , 2000, Spine.

[27]  L G Gilbertson,et al.  Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene. , 1999, Spine.

[28]  I A Stokes,et al.  Compression-induced changes in intervertebral disc properties in a rat tail model. , 1999, Spine.

[29]  J. Lotz,et al.  Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study. , 1998, Spine.

[30]  E. Viikari-Juntura,et al.  Lumbar disc degeneration in relation to occupation. , 1998, Scandinavian journal of work, environment & health.

[31]  N. Walsh.  The Bone and Joint Decade. , 1998, Archives of physical medicine and rehabilitation.

[32]  H. Tsuji,et al.  Effects of Hydrostatic Pressure on Matrix Synthesis and Matrix Metalloproteinase Production in the Human Lumbar Intervertebral Disc , 1997, Spine.

[33]  James D. Kang,et al.  Toward a Biochemical Understanding of Human Intervertebral Disc Degeneration and Herniation: Contributions of Nitric Oxide, Interleukins, Prostaglandin E2, and Matrix Metalloproteinases , 1997, Spine.

[34]  James D. Kang,et al.  Herniated Lumbar Intervertebral Discs Spontaneously Produce Matrix Metalloproteinases, Nitric Oxide, Interleukin-6, and Prostaglandin E2 , 1996, Spine.

[35]  S. Roberts,et al.  Mechanoreceptors in Intervertebral Discs: Morphology, Distribution, and Neuropeptides , 1995, Spine.

[36]  James D. Kang,et al.  Herniated Cervical Intervertebral Discs Spontaneously Produce Matrix Metalloproteinases, Nitric Oxide, Interleukin‐6, and Prostaglandin E2 , 1995, Spine.

[37]  J. Saal,et al.  Human Disc Phospholipase A2 is Inflammatory , 1992, Spine.

[38]  J. Saal,et al.  High Levels of Inflammatory Phospholipase A2 Activity in Lumbar Disc Herniations , 1990, Spine.

[39]  F. Marchand,et al.  Investigation of the Laminate Structure of Lumbar Disc Anulus Fibrosus , 1990, Spine.

[40]  R. Deyo,et al.  How many days of bed rest for acute low back pain? A randomized clinical trial. , 1986, The New England journal of medicine.

[41]  D. Eyre,et al.  Types I and II collagens in intervertebral disc. Interchanging radial distributions in annulus fibrosus. , 1976, The Biochemical journal.

[42]  H. Hall,et al.  Evidence-informed management of chronic low back pain with physical activity, smoking cessation, and weight loss. , 2008, The spine journal : official journal of the North American Spine Society.

[43]  Kevin F. Spratt,et al.  Classification of Age-Related Changes in Lumbar Intervertebral Discs , 2002 .

[44]  D. Seaman.  Mechanoreceptors in intervertebral discs. , 1996, Spine.