Left ventricular dysfunction in normotensive Type 1 diabetic patients: the impact of autonomic neuropathy

Aims  The pathophysiological mechanisms responsible for increased cardiovascular mortality in diabetic autonomic neuropathy (AN) are largely unknown. The aim was to determine the relative role of AN in the pathogenesis of cardiac diastolic dysfunction and left ventricular hypertrophy in Type 1 diabetes.

[1]  D. Iarussi,et al.  Left ventricular performance and autonomic dysfunction in patients with long-term insulin-dependent diabetes mellitus , 1996, Acta Diabetologica.

[2]  N. Christensen,et al.  Haemodynamic changes during graded exercise in patients with diabetic autonomic neuropathy , 1982, Diabetologia.

[3]  K. Karavanaki,et al.  Coexistence of Impaired Indices of Autonomic Neuropathy and Diabetic Nephropathy in a Cohort of Children with Type 1 Diabetes Mellitus , 2003, Journal of pediatric endocrinology & metabolism : JPEM.

[4]  D. Bell,et al.  Diabetic cardiomyopathy. , 2003, Diabetes care.

[5]  Lan Mao,et al.  Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy. , 2001, Journal of the American College of Cardiology.

[6]  B V Howard,et al.  The impact of diabetes on left ventricular filling pattern in normotensive and hypertensive adults: the Strong Heart Study. , 2001, Journal of the American College of Cardiology.

[7]  V. Spallone,et al.  Factors determining the 24-h blood pressure profile in normotensive patients with type 1 and type 2 diabetes , 2001, Journal of Human Hypertension.

[8]  B. Maron,et al.  Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy. , 2000, The New England journal of medicine.

[9]  A. Diedrich,et al.  Sympathetically mediated hypertension in autonomic failure. , 2000, Circulation.

[10]  P. Monteagudo,et al.  Influence of autonomic neuropathy upon left ventricular dysfunction in insulin‐dependent diabetic patients , 2000, Clinical cardiology.

[11]  S. Tuhrim,et al.  Hypertensive cardiovascular damage in patients with primary autonomic failure , 2000, The Lancet.

[12]  H. Parving,et al.  Increased Left Ventricular Mass in Normotensive Type 1 Diabetic Patients With Diabetic Nephropathy , 1998, Diabetes Care.

[13]  G. Sundkvist,et al.  Parasympathetic neuropathy associated with left ventricular diastolic dysfunction in patients with insulin-dependent diabetes mellitus. , 1998, Scandinavian cardiovascular journal : SCJ.

[14]  J. Jordan,et al.  The hypertension of autonomic failure and its treatment. , 1997, Hypertension.

[15]  J. Seward,et al.  The noninvasive assessment of left ventricular diastolic function with two-dimensional and Doppler echocardiography. , 1997, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[16]  K. Sørensen,et al.  Incipient Cardiomyopathy in Young Insulin‐dependent Diabetic Patients: A Seven‐year Prospective Doppler Echocardiographic Study , 1996, Diabetic medicine : a journal of the British Diabetic Association.

[17]  D. Bell,et al.  Diabetic Cardiomyopathy: A unique entity or a complication of coronary artery disease? , 1995, Diabetes Care.

[18]  L. Wilkins.  Proceedings of a Consensus Development Conference on Standardized Measures in Diabetic Neuropathy , 1992, Neurology.

[19]  M. Uusitupa,et al.  Left ventricular function and dimensions in newly diagnosed non-insulin-dependent diabetes mellitus. , 1992, The American journal of cardiology.

[20]  D. Spodick.  Colchicine therapy of recurrent pericarditis. , 1991, Circulation.

[21]  K. Airaksinen,et al.  Diabetic heart muscle disease. , 1990, Annals of medicine.

[22]  M. Starling.  Does clinic definable diabetic cardiomypathy exist , 1990 .

[23]  T. Riggs,et al.  Doppler echocardiographic evaluation of left ventricular diastolic function in adolescents with diabetes mellitus. , 1990, The American journal of cardiology.

[24]  M. Starling.  Does a clinically definable diabetic cardiomyopathy exist? , 1990, Journal of the American College of Cardiology.

[25]  P. Passa,et al.  Prevalence and significance of left ventricular filling abnormalities determined by Doppler echocardiography in young type I (insulin-dependent) diabetic patients. , 1989, The American journal of cardiology.

[26]  M. Roberts,et al.  Diastolic abnormalities in young asymptomatic diabetic patients assessed by pulsed Doppler echocardiography. , 1988, Journal of the American College of Cardiology.

[27]  N. Secher,et al.  Role of motor center activity for hormonal changes and substrate mobilization in humans. , 1987, The American journal of physiology.

[28]  A. Pegg,et al.  Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin. , 1987, The American journal of physiology.

[29]  J. Nordrehaug,et al.  Subclinical left ventricular abnormalities in young subjects with long-term type 1 diabetes mellitus detected by digitized M-mode echocardiography. , 1987, The American journal of cardiology.

[30]  T. Hintze,et al.  Absence of hypertension despite chronic marked elevations in plasma norepinephrine in conscious dogs. , 1987, Hypertension.

[31]  A. Vinik,et al.  Abnormal cardiac function in diabetic patients with autonomic neuropathy in the absence of ischemic heart disease. , 1986, The Journal of clinical endocrinology and metabolism.

[32]  A. Vinik,et al.  Radionuclide assessment of left ventricular diastolic filling in diabetes mellitus with and without cardiac autonomic neuropathy. , 1986, Journal of the American College of Cardiology.

[33]  P. Simpson,et al.  Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating. , 1985, Circulation research.

[34]  M. Ikäheimo,et al.  Impaired left ventricular filling in young female diabetics. An echocardiographic study. , 2009, Acta medica Scandinavica.

[35]  P. Manning,et al.  Guanethidine-induced destruction of sympathetic neurons. , 1984, International review of neurobiology.

[36]  P. Simpson.  Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response. , 1983, The Journal of clinical investigation.

[37]  D. Goldstein,et al.  High Prevalence of Echocardiographic Abnormalities in Diabetic Youths , 1983, Diabetes Care.

[38]  L. Shapiro.  Echocardiographic features of impaired ventricular function in diabetes mellitus. , 1982, British heart journal.

[39]  N. Christensen,et al.  Hemodynamics in diabetic orthostatic hypotension. , 1981, The Journal of clinical investigation.

[40]  L. Shapiro,et al.  Left ventricular function in diabetes mellitus. I: Methodology, and prevalence and spectrum of abnormalities. , 1981, British heart journal.

[41]  B. Leatherdale,et al.  Left ventricular function in diabetes mellitus. II: Relation between clinical features and left ventricular function. , 1981, British heart journal.

[42]  A. DeMaria,et al.  Recommendations Regarding Quantitation in M-Mode Echocardiography: Results of a Survey of Echocardiographic Measurements , 1978, Circulation.

[43]  S. Ahmed,et al.  Evidence for cardiomyopathy in familial diabetes mellitus. , 1977, The Journal of clinical investigation.

[44]  W. Kannel,et al.  Role of diabetes in congestive heart failure: the Framingham study. , 1974, The American journal of cardiology.

[45]  F. Morady,et al.  Myocardial hypertrophy produced by chronic infusion of subhypertensive doses of norepinephrine in the dog. , 1973, Chest.

[46]  A. Grishman,et al.  New type of cardiomyopathy associated with diabetic glomerulosclerosis. , 1972, The American journal of cardiology.