Two-graph receiver operating characteristic (TG-ROC): update version supports optimisation of cut-off values that minimise overall misclassification costs.

TG-ROC was recently introduced as a novel PC-assisted device for cut-off optimisation and evaluation of quantitative serodiagnostic tests (Greiner, 1995, J. Immunol. Methods 185, 145; Greiner et al., 1995, J. Immunol. Methods 185, 123). In this notice a recent extension of the programme is described which facilitates the cut-off selection when estimates of costs associated with false-positive and false-negative results are available.