Red cell storage in E‐Sol 5 and Adsol additive solutions: paired comparison using mixed and non‐mixed study designs

If transfusion of older stored red cells is found to negatively affect clinical outcome, one possible alternative to shortened outdate is the use of new additive solutions (AS) that ameliorate the storage lesion. Erythro‐Sol (E‐Sol), a previously developed next‐generation AS, has been reformulated into E‐Sol 5, which is compatible with current anticoagulants and AS volumes. The effect of E‐Sol 5 on red cells during storage compared to current AS has not been reported.

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