Reaction time in healthy elderly is associated with chronic low-grade inflammation and advanced glycation end product

ABSTRACT Chronic inflammation and Advanced Glycation End products (AGE) are associated with sarcopenia. Decreased voluntary muscle activation and increased antagonist coactivation can contribute to age‐related muscle weakness. The influence of chronic inflammation and AGE in these neuromuscular mechanisms is not clear. We studied whether a relation exists between circulating levels of inflammatory cytokines and AGEs as well as the interplay between agonist and antagonist muscle activation. We studied 64 community‐dwelling old subjects, during a maximal isometric voluntary contraction (MVC) and a reaction‐time (RT) test of the upper limb. Twenty‐five circulating inflammatory biomarkers were determined. Linear regression showed significant relationships between chronic inflammation and six muscle activation parameters. MIP‐1&bgr; showed a significant negative relation with antagonist coactivation (during MVC) and antagonist muscle activity during pre‐movement time (PMT) and movement time (MT) (during RT). A higher level of pentosidine (AGE) was predictive for a longer PMT. We conclude that in older relatively healthy persons antagonist muscle activation is influenced by chronic inflammation, contributing to age‐related muscle weakness. Our results also suggest a mechanical and inflammatory influence of pentosidine in upper limb slowing of movement. These findings show novel insight in underlying mechanisms of age‐related muscle weakness. HIGHLIGHTSRelations of inflammation & AGE's with antagonist muscle activation were studied.Inflammation related negatively to antagonist activation during maximal contraction.MIP‐1&bgr; was negatively related to antagonist activity during a reaction time test.A higher level of pentosidine was predictive for a longer pre‐movement time.We provided novel insight in underlying mechanisms of age‐related muscle weakness.

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