论文信息 - GC-MS/MS Analyses of Biological Samples in Support of Developmental Toxic Effects on Subcutaneous Exposure of Rats to GB

GC-MS/MS Analyses of Biological Samples in Support of Developmental Toxic Effects on Subcutaneous Exposure of Rats to GB

Abstract : This report documents the results of gas chromatography-tandem mass spectrometry (GC-MS/MS) analyses of blood, tissues, and organs (heart, lung, liver, kidney, brain, eye, diaphragm, and skin) that were obtained from rats (postnatal days 42 and 70) percutaneously exposed to various concentrations of O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX). The amount of O-ethyl methylphosphonofluoridate (VX-G) present in these biological samples was quantified using chemical ionization mass spectrometry with isotope dilution. In addition, free VX present on the skin surface was quantified from cellophane tape strip sampling using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Paul S. Demond | L. Lumley | Michael W. Busch | J. McGuire | L. Wright

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