Expanding the Paradigm for Cardiovascular Palliative Care

Cardiovascular disease (CVD) is the leading cause of death worldwide. Despite medical advances, patients with CVD experience high morbidity and mortality rates, affecting their quality of life and death. Among CVD conditions, palliative care has been studied mostly in patients with heart failure, where palliative care interventions have been associated with improvements in patient-centered outcomes, including quality of life, end-of-life care, and health care use. Although palliative care is now incorporated into the American Heart Association/American College of Cardiology/Heart Failure Society of America guidelines for heart failure, the role of palliative care for non–heart failure CVD remains uncertain. Across all causes of CVD, palliative care can play an important role in all domains of CVD care from initial diagnosis to terminal care. In addition to general cardiovascular palliative care practices applicable to all areas, disease-specific palliative care needs may warrant individualized palliative care models. In this review, we discuss the role of cardiovascular palliative care for ischemic heart disease, valvular disease, arrhythmias, peripheral artery disease, and adult congenital heart disease. Although there are multiple barriers to cardiovascular palliative care, we recommend a framework for studying and developing cardiovascular palliative care models to improve patient-centered goal-concordant care for this underserved patient population.

[1]  Rizwan Kalani,et al.  Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association , 2023, Circulation.

[2]  E. Bacha,et al.  Palliative Care Across the Life Span for Children With Heart Disease: A Scientific Statement From the American Heart Association. , 2023, Circulation. Cardiovascular quality and outcomes.

[3]  K. Alexander,et al.  Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association , 2022, Circulation.

[4]  C. Ayers,et al.  ICD Knowledge and Attitudes at End of Life in a Diverse and Vulnerable Patient Population , 2022, Journal of health care for the poor and underserved.

[5]  J. Dearani,et al.  Incidence and Outcomes of Advanced Heart Failure in Adults With Congenital Heart Disease , 2022, Circulation. Heart failure.

[6]  M. B. Allen,et al.  Peri‐procedural code status for transcatheter aortic valve replacement: Absence of program policies and standard practices , 2022, Journal of the American Geriatrics Society.

[7]  L. Allen,et al.  Criteria for Referral of Patients With Advanced Heart Failure for Specialized Palliative Care. , 2022, Journal of the American College of Cardiology.

[8]  R. Kheirbek,et al.  Palliative Care Consultation is Associated with Decreased Rates of In-Hospital Mortality Among Patients Undergoing Major Amputation. , 2022, Annals of vascular surgery.

[9]  S. Sinha,et al.  Integrating palliative care into the modern cardiac intensive care unit: a review. , 2022, European heart journal. Acute cardiovascular care.

[10]  M. Link,et al.  2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. , 2022, Circulation.

[11]  Adam W. Black,et al.  Rural disparities in end-of-life care for patients with heart failure: Are they due to geography or socioeconomic disparity? , 2021, The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association.

[12]  J. Coresh,et al.  Psychosocial factors and subsequent risk of hospitalizations with peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study. , 2021, Atherosclerosis.

[13]  J. Kirkpatrick,et al.  It's part of who I am: The impact of congenital heart disease on adult identity and life experience , 2021 .

[14]  D. Theuns,et al.  Advance care planning and end-of-life care in patients with an implantable cardioverter defibrillator: The perspective of relatives , 2021, Palliative medicine.

[15]  M. Khan,et al.  Association of Palliative Care Intervention with Health Care Use, Symptom Burden and Advance Care Planning in Adults with Heart Failure and Other Noncancer Chronic Illness. , 2021, Journal of pain and symptom management.

[16]  M. Mell,et al.  Underutilization Of Palliative Care For Patients With Advanced Peripheral Arterial Disease , 2021 .

[17]  Francesca N. Delling,et al.  Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association. , 2021, Circulation.

[18]  T. Lüscher,et al.  Management of refractory angina: an update. , 2020, European heart journal.

[19]  H. Ross,et al.  Referral Practices of Cardiologists to Specialist Palliative Care in Canada , 2020, CJC open.

[20]  T Kashiwagi,et al.  What is palliative care? , 2020, InnovAiT: Education and inspiration for general practice.

[21]  E. Volz,et al.  Home Is Where the Heart Is: The Impact of Home-Based Palliative Care on Patients with Advanced Heart Failure , 2020 .

[22]  C. Cox,et al.  Operationalizing needs-focused palliative care for older adults in intensive care units: Design of and rationale for the PCplanner randomized clinical trial. , 2020, Contemporary clinical trials.

[23]  A. Gadoud,et al.  Refractory angina is a growing challenge for palliative medicine: a systematic review of non-invasive interventions , 2020, BMJ Supportive & Palliative Care.

[24]  P. Gozalo,et al.  Palliative Care Consultation Reduces Heart Failure Transitions: A Matched Analysis , 2020, Journal of the American Heart Association.

[25]  P. Joseph,et al.  The impact of palliative care on clinical and patient‐centred outcomes in patients with advanced heart failure: a systematic review of randomized controlled trials , 2020, European journal of heart failure.

[26]  M. Kamalesh,et al.  One‐year mortality after implantable cardioverter‐defibrillator placement within the Veterans Affairs Health System , 2020, European journal of heart failure.

[27]  S. Pantilat,et al.  A Comparison of Hospitalized Patients With Heart Failure and Cancer Referred to Palliative Care , 2020, JAMA network open.

[28]  Marco Valgimigli,et al.  2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. , 2019, European heart journal.

[29]  A. Morris,et al.  Palliative Care and End-of-Life Outcomes Following High-Risk Surgery. , 2020, JAMA surgery.

[30]  D. Bichell,et al.  Advanced Heart Failure in Adults With Congenital Heart Disease. , 2019, JACC. Heart failure.

[31]  P. Tanuseputro,et al.  End‐of‐life care following leg amputation in patients with peripheral artery disease or diabetes , 2019, The British journal of surgery.

[32]  D. Redfearn,et al.  Deactivation of Implantable Cardioverter Defibrillator in Patients With Terminal Diagnoses. , 2019, The American journal of cardiology.

[33]  D. Munday,et al.  Defining primary palliative care for universal health coverage , 2019, The Lancet.

[34]  G. Samsa,et al.  Characteristics and Trends Among Patients With Cardiovascular Disease Referred to Palliative Care , 2019, JAMA network open.

[35]  A. van der Heide,et al.  Trends in time in the management of the implantable cardioverter defibrillator in the last phase of life: a retrospective study of medical records , 2019, European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology.

[36]  P. Macdonald,et al.  The Perspectives of Health Care Professionals on Providing End of Life Care and Palliative Care for Patients With Chronic Heart Failure: An Integrative Review. , 2019, Heart, lung & circulation.

[37]  P. Davidson,et al.  Healthcare Providers' Perceived Communication Barriers to Offering Palliative Care to Patients With Heart Failure: An Integrative Review , 2019, The Journal of cardiovascular nursing.

[38]  T. Ando,et al.  Incidence, Trends, and Predictors of Palliative Care Consultation After Aortic Valve Replacement in the United States , 2018, Journal of palliative care.

[39]  J. Kirkpatrick,et al.  Perspectives on advance care planning and palliative care among adults with congenital heart disease. , 2018, Congenital heart disease.

[40]  J. Spertus,et al.  The Evolution of Patient-Reported Outcomes in Clinical Trials and Management of Patients With Coronary Artery Disease: 20 Years With the Seattle Angina Questionnaire. , 2018, JAMA cardiology.

[41]  J. Jackson,et al.  Depressive and Anxiety Symptoms in Adult Congenital Heart Disease: Prevalence, Health Impact and Treatment. , 2018, Progress in cardiovascular diseases.

[42]  Terry Fulmer,et al.  Physicians' Views on Advance Care Planning and End‐of‐Life Care Conversations , 2018, Journal of the American Geriatrics Society.

[43]  Akshay S. Desai,et al.  Social Worker–Aided Palliative Care Intervention in High-risk Patients With Heart Failure (SWAP-HF): A Pilot Randomized Clinical Trial , 2018, JAMA cardiology.

[44]  A. Jemal,et al.  Ovarian cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[45]  D. Polk,et al.  Palliative Care Education in Cardiology. , 2018, Journal of the American College of Cardiology.

[46]  A. Auricchio,et al.  Defibrillator shocks and their effect on objective and subjective patient outcomes: Results of the PainFree SST clinical trial. , 2017, Heart rhythm.

[47]  W. Oetgen,et al.  The NCDR ICD Registry: A Foundation for Quality Improvement. , 2017, Journal of the American College of Cardiology.

[48]  J. Kirkpatrick,et al.  Palliative care in end-stage valvular heart disease , 2017, Heart.

[49]  K. Anstrom,et al.  Palliative Care in Heart Failure: The PAL-HF Randomized, Controlled Clinical Trial. , 2017, Journal of the American College of Cardiology.

[50]  A. Kovacs,et al.  Advance Care Planning in Adults with Congenital Heart Disease: A Patient Priority. , 2017, International journal of cardiology.

[51]  G. Moneta,et al.  Patterns of Care in Hospitalized Vascular Surgery Patients at End of Life , 2017, JAMA surgery.

[52]  T. Shanafelt,et al.  Future of the Palliative Care Workforce: Preview to an Impending Crisis. , 2017, The American journal of medicine.

[53]  S. Normand,et al.  Hospice Use Following Implantable Cardioverter-Defibrillator Implantation in Older Patients , 2016, Circulation.

[54]  P. Lee,et al.  Effects of a transitional palliative care model on patients with end-stage heart failure: a randomised controlled trial , 2016, Heart.

[55]  K. Boman,et al.  A cost-effectiveness study of person-centered integrated heart failure and palliative home care: Based on a randomized controlled trial , 2016, Palliative medicine.

[56]  R. Morrison,et al.  Palliative Care for the Seriously Ill. , 2015, The New England journal of medicine.

[57]  J. Robb,et al.  Patient‐defined goals for the treatment of severe aortic stenosis: a qualitative analysis , 2015, Health expectations : an international journal of public participation in health care and health policy.

[58]  S. Dunlay,et al.  A survey of clinician attitudes and self-reported practices regarding end-of-life care in heart failure , 2015, Palliative medicine.

[59]  A. Sillah,et al.  Inpatient palliative care for patients with acute heart failure: outcomes from a randomized trial. , 2015, Journal of palliative medicine.

[60]  K. Boman,et al.  Effects of person‐centred and integrated chronic heart failure and palliative home care. PREFER: a randomized controlled study , 2014, European journal of heart failure.

[61]  T. Henry,et al.  Treatment of refractory angina in patients not suitable for revascularization , 2014, Nature Reviews Cardiology.

[62]  A. Abernethy,et al.  “Not the ‘Grim Reaper Service’”: An Assessment of Provider Knowledge, Attitudes, and Perceptions Regarding Palliative Care Referral Barriers in Heart Failure , 2014, Journal of the American Heart Association.

[63]  M. Drazner,et al.  2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. , 2013, Circulation.

[64]  Abrar H. Shah,et al.  End‐of‐Life Care in Patients with Implantable Cardioverter Defibrillators: A MADIT‐II Substudy , 2013, Pacing and clinical electrophysiology : PACE.

[65]  E. Prescott,et al.  Persistent angina: highly prevalent and associated with long-term anxiety, depression, low physical functioning, and quality of life in stable angina pectoris , 2013, Clinical Research in Cardiology.

[66]  A. Abernethy,et al.  Generalist plus specialist palliative care--creating a more sustainable model. , 2013, The New England journal of medicine.

[67]  I. Higginson,et al.  Heterogeneity and changes in preferences for dying at home: a systematic review , 2013, BMC Palliative Care.

[68]  J. Deanfield,et al.  Quality of life of adult congenital heart disease patients: a systematic review of the literature , 2013, Cardiology in the Young.

[69]  Shaista Malik,et al.  Examining the effects of an outpatient palliative care consultation on symptom burden, depression, and quality of life in patients with symptomatic heart failure. , 2012, Journal of cardiac failure.

[70]  S. Mitchell,et al.  Deactivation of pacemakers and implantable cardioverter-defibrillators. , 2012, Progress in cardiovascular diseases.

[71]  A. Mason,et al.  Collaborative palliative care for advanced heart failure: outcomes and costs from the ‘Better Together’ pilot study , 2012, BMJ Supportive & Palliative Care.

[72]  K. Fox,et al.  Cardiac Rehabilitation to Improve Physical Functioning in Refractory Angina: A Pilot Study , 2012, Cardiology.

[73]  A. Kovacs,et al.  Knowledge of and preference for advance care planning by adults with congenital heart disease. , 2012, The American journal of cardiology.

[74]  Susheel Kodali,et al.  Transcatheter aortic-valve replacement for inoperable severe aortic stenosis. , 2012, The New England journal of medicine.

[75]  C. Raphael Deactivation of implantable cardioverter-defibrillators in terminal illness and end-of-life care. , 2012, The American journal of cardiology.

[76]  A. Kovacs,et al.  End-of-life in adults with congenital heart disease: a call for early communication. , 2012, International journal of cardiology.

[77]  A. Kovacs,et al.  End-of-life care in hospitalized adults with complex congenital heart disease: care delayed, care denied , 2012, Palliative medicine.

[78]  D. Meier,et al.  America's care of serious illness: a state-by-state report card on access to palliative care in our nation's hospitals. , 2011, Journal of palliative medicine.

[79]  L. Allen,et al.  Palliative care and hospice in advanced heart failure. , 2011, Progress in cardiovascular diseases.

[80]  G. Annas,et al.  Hrs Expert Consensus Statement on the Management of Cardiovascular Implantable Electronic Devices (cieds) in Patients Nearing End of Life or Requesting Withdrawal of Therapy Introduction , 2022 .

[81]  Emily A. Kuhl,et al.  Depression and anxiety in adult congenital heart disease: predictors and prevalence. , 2009, International journal of cardiology.

[82]  W. Lewis,et al.  Should implantable cardioverter-defibrillators and permanent pacemakers in patients with terminal illness be deactivated? Deactivating permanent pacemaker in patients with terminalillness. Patient autonomy is paramount. , 2009, Circulation. Arrhythmia and electrophysiology.

[83]  A. Tsiatis,et al.  Quality of life with defibrillator therapy or amiodarone in heart failure. , 2008, The New England journal of medicine.

[84]  D. Groves,et al.  A brief cognitive-behavioral intervention reduces hospital admissions in refractory angina patients. , 2007, Journal of pain and symptom management.

[85]  R. Bush,et al.  Quality of life and peripheral arterial disease. , 2006, The Journal of surgical research.

[86]  D. Groves,et al.  Health related quality of life of patients with refractory angina before and one year after enrolment onto a refractory angina program , 2005, European journal of pain.

[87]  H. Vliegen,et al.  Health related quality of life and health status in adult survivors with previously operated complex congenital heart disease , 2002, Heart.

[88]  A. Bernstein,et al.  Patients' Attitudes Toward Implanted Defibrillator Shocks , 2000, Pacing and clinical electrophysiology : PACE.

[89]  H. Li,et al.  Sudden death in patients with implantable cardioverter-defibrillators. , 1996, American heart journal.

[90]  R. Langer,et al.  Mortality over a period of 10 years in patients with peripheral arterial disease. , 1992, The New England journal of medicine.

[91]  E. Jones Disease , 2020, Palgrave Studies in Economic History.

[92]  F. Wong,et al.  Effects of a Home-Based Palliative Heart Failure Program on Quality of Life, Symptom Burden, Satisfaction and Caregiver Burden: A Randomized Controlled Trial. , 2018, Journal of pain and symptom management.

[93]  M. Zile,et al.  Palliative Care for Advanced Heart Failure in a Department of Veterans Affairs Regional Hospice Program: Patient Selection, a Treatment Protocol, and Clinical Course. , 2017, Journal of palliative medicine.

[94]  A. Kajanová,et al.  Comparison of Health-Related Quality of Life Between Patients with Implantable Cardioverter Defibrillators and Pacemaker Recipients , 2017 .

[95]  J. Rudolph,et al.  Palliative Care Interventions for Patients with Heart Failure: A Systematic Review and Meta-Analysis. , 2017, Journal of palliative medicine.

[96]  M. Rosenqvist,et al.  Put Into Perspective for the Practicing Clinician 411 Implantable Cardioverter-Defibrillator Therapy Before Death : High Risk for Painful Shocks at End of Life , 2014 .

[97]  O. Brawley,et al.  Disparities in Access to Palliative Care , 2014 .

[98]  D. Meier,et al.  Meeting the Needs of Older Adults with Serious Illness , 2014 .