Reconfigurable, Multi-channel and Modular Bioimpedance Spectroscopy System on Field Programmable Gate Arrays

This paper presents the design and implementation of a multichannel bio-impedance spectroscopy system on field programmable gate arrays (FPGA). The proposed system is capable of acquiring multiple signals from multiple bio-impedance sensors, process the data on the FPGA and store the final data in the on-board Memory. The system employs the Digital Automatic Balance Bridge (DABB) method to acquire data from biosensors. The DABB measures initial data of a known impedance to extrapolate the value of the impedance for the device under test. This method offers a simpler design because the balancing of the circuit is done digitally in the FPGA rather than using an external circuit. Calculations of the impedance values for the device under test were done in the processor. The final data is sent to an onboard Flash Memory to be stored for later access. The control unit handles the interfacing and the scheduling between these different modules (Processor, Flash Memory) as well as interfacing to multiple Balance Bridge and multiple biosensors. The system has been simulated successfully and has comparable performance to other FPGA based solutions. The system has a robust design that is capable of handling and interfacing input from multiple biosensors. Data processing and storage is also performed with minimal resources on the FPGA.

[1]  John H. Miller,et al.  Nonlinear Impedance of Whole Cells Near an Electrode as a Probe of Mitochondrial Activity , 2011, Biosensors.

[2]  Richard D. Beach,et al.  Towards a miniature implantable in vivo telemetry monitoring system dynamically configurable as a potentiostat or galvanostat for two- and three-electrode biosensors , 2005, IEEE Transactions on Instrumentation and Measurement.

[3]  E. Alocilja,et al.  Design and fabrication of a microimpedance biosensor for bacterial detection , 2004, IEEE Sensors Journal.

[4]  Jack E. Volder The CORDIC Trigonometric Computing Technique , 1959, IRE Trans. Electron. Comput..

[5]  Juvenal Rodríguez-Reséndiz,et al.  Dual-Phase Lock-In Amplifier Based on FPGA for Low-Frequencies Experiments , 2016, Sensors.

[6]  Miqin Zhang,et al.  Cellular impedance biosensors for drug screening and toxin detection. , 2007, The Analyst.

[7]  R. Salomon,et al.  CDL, a Precise, Low-Cost Coincidence Detector Latch , 2015 .

[8]  Hui Xu,et al.  Wide bandwidth cell impedance spectroscopy based on digital auto balancing bridge method , 2011, 2011 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[9]  Steffen Leonhardt,et al.  System Description and First Application of an FPGA-Based Simultaneous Multi-Frequency Electrical Impedance Tomography , 2016, Sensors.

[10]  Marco Tartagni,et al.  A Low-cost and Portable System for Real-time Impedimetric Measurements and Impedance Spectroscopy of Sensors , 2012 .

[11]  Lin Yang,et al.  In Vivo Bioimpedance Spectroscopy Characterization of Healthy, Hemorrhagic and Ischemic Rabbit Brain within 10 Hz–1 MHz , 2017, Sensors.

[12]  Patrick Schweitzer,et al.  Embedded System Design for Impedance Measurement of Multi-piezo Sensor , 2010, 2010 Third International Conference on Advances in Circuits, Electronics and Micro-electronics.