“Normal” liver stiffness values differ between men and women: A prospective study for healthy living liver and kidney donors in a native Korean population

Background and Aim:  Liver stiffness (LS) measurement can distinguish individuals with potential liver disease (LD) from the general population. However, if LS is sex‐sensitive, prevalence of LD may be incorrectly estimated when the same reference LS value is applied irrespective of sex. Here, we evaluated whether normal ranges of LS differ between healthy men and women.

[1]  Z. Goodman,et al.  Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis c. , 2001, Journal of hepatology.

[2]  V. Seagroatt.  An introduction to medical statistics (2nd ed.) , 1996 .

[3]  M. Greenwood.  An Introduction to Medical Statistics , 1932, Nature.

[4]  M. Brunetto,et al.  Liver stiffness in the hepatitis B virus carrier: a non-invasive marker of liver disease influenced by the pattern of transaminases. , 2008, World journal of gastroenterology.

[5]  A. Nakajima,et al.  Transient elastography in patients with non-alcoholic fatty liver disease (NAFLD) , 2007, Gut.

[6]  Z. Younossi,et al.  Evaluation and management of obesity-related nonalcoholic fatty liver disease , 2007, Nature Clinical Practice Gastroenterology &Hepatology.

[7]  A. Marcos.  Right lobe living donor liver transplantation: A review , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[8]  Z. Sparchez,et al.  745 THE INFLUENCE OF FATTY LOAD ON LIVER STIFFNESS IN CHRONIC HEPATITIS C PATIENTS , 2008 .

[9]  I. Shimizu,et al.  Suppressive effects of estradiol on dimethylnitrosamine‐induced fibrosis of the liver in rats , 1999, Hepatology.

[10]  Robert C. Wolpert,et al.  A Review of the , 1985 .

[11]  C. Corpechot,et al.  Gender and liver: Is the liver stiffness weaker in weaker sex? , 2006, Hepatology.

[12]  V. Paradis,et al.  Progression of liver fibrosis in women infected with hepatitis C: Long‐term benefit of estrogen exposure , 2004, Hepatology.

[13]  I. Shimizu.  Impact of oestrogens on the progression of liver disease , 2003, Liver international : official journal of the International Association for the Study of the Liver.

[14]  S. Ahn,et al.  What are ‘true normal’ liver stiffness values using FibroScan®?: a prospective study in healthy living liver and kidney donors in South Korea , 2010, Liver international : official journal of the International Association for the Study of the Liver.

[15]  Anne-Claire Vergnaud,et al.  Liver stiffness values in apparently healthy subjects: influence of gender and metabolic syndrome. , 2008, Journal of hepatology.

[16]  F. Chan,et al.  Clinical and histological features of non‐alcoholic fatty liver disease in Hong Kong Chinese , 2004, Alimentary pharmacology & therapeutics.

[17]  Paul Zimmet,et al.  The metabolic syndrome—a new worldwide definition , 2005, The Lancet.

[18]  W. Kannel,et al.  The natural history of congestive heart failure: the Framingham study. , 1971, The New England journal of medicine.

[19]  Christos Christidis,et al.  Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C , 2005, Hepatology.

[20]  M. Bia,et al.  The evaluation and selection of living kidney donors. , 1995, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[21]  G. Everson,et al.  Evaluation of 100 patients for living donor liver transplantation , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[22]  M. Campbell,et al.  Noninvasive Assessment of Liver Fibrosis by Measurement of Stiffness in Patients With Chronic Hepatitis C , 2006 .

[23]  M. Manns,et al.  A comparison of fibrosis progression in chronic liver diseases. , 2003, Journal of hepatology.

[24]  Y. N. Park,et al.  Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in Chronic Hepatitis B , 2009, Digestive Diseases and Sciences.

[25]  S. Ito,et al.  Protection of estrogens against the progression of chronic liver disease , 2007, Hepatology research : the official journal of the Japan Society of Hepatology.

[26]  Pierre Bedossa,et al.  Non‐invasive assessment of liver fibrosis by stiffness measurement in patients with chronic hepatitis B , 2009, Liver international : official journal of the International Association for the Study of the Liver.

[27]  Dario Conte,et al.  Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease , 2007, Gut.

[28]  S. Ahn,et al.  Transient elastography in chronic hepatitis B: an Asian perspective. , 2010, World journal of gastroenterology.

[29]  Y. N. Park,et al.  Liver Stiffness Measurement in Combination With Noninvasive Markers for the Improved Diagnosis of B-viral Liver Cirrhosis , 2009, Journal of clinical gastroenterology.

[30]  F. Oberti,et al.  Learning curve and interobserver reproducibility evaluation of liver stiffness measurement by transient elastography: , 2017 .

[31]  S. Sanderson,et al.  The natural history of nonalcoholic fatty liver disease: a population-based cohort study. , 2005, Gastroenterology.

[32]  M. Ziol,et al.  87 Prediction of liver fibrosis in non-alcoholic steatohepatitis (NASH): Risk factors and diagnostic potential of liver elasticity using fibroscan , 2006 .

[33]  I. Sporea,et al.  Transient elastographic evaluation of subjects without known hepatic pathology: does age change the liver stiffness? , 2009, Journal of gastrointestinal and liver diseases : JGLD.

[34]  M. Ziol,et al.  Assessment of biliary fibrosis by transient elastography in patients with PBC and PSC , 2006, Hepatology.

[35]  M. Ziol,et al.  Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. , 2003, Ultrasound in medicine & biology.

[36]  A. Clouston,et al.  Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis , 1999, Hepatology.

[37]  M. Yuen,et al.  Correlation of liver biochemistry with liver stiffness in chronic hepatitis B and development of a predictive model for liver fibrosis , 2008, Liver international : official journal of the International Association for the Study of the Liver.

[38]  K. Reddy,et al.  Progression of liver fibrosis in women infected with hepatitis C: Long‐term benefit of estrogen exposure , 2005, Hepatology.

[39]  S. Fan,et al.  Correlation of Liver Stiffness and Histological Features in Healthy Persons and in Patients With Occult Hepatitis B, Chronic Active Hepatitis B, or Hepatitis B Cirrhosis , 2010, The American Journal of Gastroenterology.

[40]  M. Ziol,et al.  Features associated with success rate and performance of FibroScan measurements for the diagnosis of cirrhosis in HCV patients: a prospective study of 935 patients. , 2007, Journal of hepatology.