Diagnosis of oral submucous fibrosis with optical coherence tomography.

The epithelium (EP) thickness and the standard deviation (SD) of A-mode scan intensity in the laminar propria (LP) layer are used as effective indicators for the diagnosis of oral submucous fibrosis (OSF) based on the noninvasive clinical scanning of a swept-source optical coherence tomography (OCT) system of approximately 6 mum in axial resolution (in tissue) and 103 dB in sensitivity. Compared with the corresponding parameters in healthy oral mucosal mucosa, in OSF mucosa, the EP thickness becomes smaller and the SD of A-mode scan intensity in the LP layer (LP SD) also becomes smaller. The LP SD can also be used for effectively differentiating OSF (small LP SD) from lesion (large LP SD). This application is particularly useful in the case of a lesion without a clear surface feature. Meanwhile, the use of the SD of A-mode scan intensity in the EP layer (EP SD) can further help in differentiating OSF (medium EP SD) from healthy oral mucosal (small EP SD) and lesion (large EP SD) conditions. Compared with the conventional method of maximum mouth opening measurement, the use of the proposed OCT scanning results can be a more effective technique for OSF diagnosis.

[1]  W. Harvey,et al.  Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids. , 1986, Archives of oral biology.

[2]  R. Kuttan,et al.  Collagen treated with (+)-catechin becomes resistant to the action of mammalian collagenase , 1981, Experientia.

[3]  N. Shah,et al.  Role of chewing and smoking habits in the etiology of oral submucous fibrosis (OSF): a case-control study. , 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[4]  I A Razak,et al.  A national epidemiological survey of oral mucosal lesions in Malaysia. , 1997, Community dentistry and oral epidemiology.

[5]  S. Sharma,et al.  Oral submucous fibrosis--a new treatment regimen. , 1988, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[6]  Shun-Fa Yang,et al.  Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinase A activity in buccal mucosal fibroblasts by arecoline as possible mechanisms for oral submucous fibrosis. , 2002, Oral oncology.

[7]  Jun Zhang,et al.  Advances in oral cancer detection using optical coherence tomography , 2005, IEEE Journal of Selected Topics in Quantum Electronics.

[8]  Y. Ko,et al.  Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors. , 1992, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[9]  Hsiang-Chieh Lee,et al.  Delineation of an oral cancer lesion with swept-source optical coherence tomography. , 2008, Journal of biomedical optics.

[10]  Zhongping Chen,et al.  In vivo optical coherence tomography for the diagnosis of oral malignancy , 2004, Lasers in surgery and medicine.

[11]  S. Warnakulasuriya,et al.  Evaluation of multiple micronutrient supplementation in the management of oral submucous fibrosis in Karachi, Pakistan. , 1997, Nutrition and cancer.

[12]  W. Harvey,et al.  Oral submucous fibrosis: its pathogenesis and management , 1986, British Dental Journal.

[13]  S. Ko,et al.  Epidemiologic study of 600 villagers of oral precancerous lesions in Bilugyun: preliminary report. , 1982, Community Dentistry and Oral Epidemiology.

[14]  P. Wilder-Smith,et al.  Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches. , 2006, Photomedicine and laser surgery.

[15]  Hsiang-Chieh Lee,et al.  Effective indicators for diagnosis of oral cancer using optical coherence tomography. , 2008, Optics express.

[16]  N. Johnson,et al.  The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma. , 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[17]  L L Otis,et al.  Imaging of the oral cavity using optical coherence tomography. , 2000, Monographs in oral science.

[18]  R Richards-Kortum,et al.  Detection and diagnosis of oral neoplasia with an optical coherence microscope. , 2004, Journal of biomedical optics.

[19]  B. Wong,et al.  In vivo optical coherence tomography of the human oral cavity and oropharynx. , 2006, Archives of otolaryngology--head & neck surgery.

[20]  Yang Jf,et al.  Collagenase activity in oral submucous fibrosis. , 1992 .

[21]  Zhongping Chen,et al.  In vivo Imaging of Oral Mucositis in an Animal Model Using Optical Coherence Tomography and Optical Doppler Tomography , 2007, Clinical Cancer Research.

[22]  B. Wong,et al.  In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients , 2005, The Laryngoscope.

[23]  R. Borle,et al.  Management of oral submucous fibrosis: a conservative approach. , 1991, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[24]  C. Tsai,et al.  Deficiency in collagen and fibronectin phagocytosis by human buccal mucosa fibroblasts in vitro as a possible mechanism for oral submucous fibrosis. , 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[25]  M. Kuo,et al.  Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. , 2000, Oral oncology.

[26]  Chih-Jen Yu,et al.  High speed interferometric ellipsometer. , 2008, Optics express.

[27]  Anastasia L. Sowers,et al.  Evaluation of Radiation-Induced Oral Mucositis by Optical Coherence Tomography , 2005, Clinical Cancer Research.

[28]  L L Otis,et al.  Optical coherence tomography: a new imaging technology for dentistry. , 2000, Journal of the American Dental Association.

[29]  P. Gupta,et al.  Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing. , 1995, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[30]  J. J. Pindborg,et al.  Oral submucous fibrosis. , 1966, Oral surgery, oral medicine, and oral pathology.

[31]  L. Chiang,et al.  Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis. , 2003, Oral oncology.

[32]  E. Kovacs.  Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. , 1991, Immunology today.

[33]  J A Lewis,et al.  Role of areca nut in the causation of oral submucous fibrosis: a case-control study in Pakistan. , 1994, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[34]  B. Wong,et al.  Optical Coherence Tomography of Laryngeal Cancer , 2006, The Laryngoscope.

[35]  M. Kuo,et al.  Collagen Biosynthesis in Human Oral Submucous Fibrosis Fibroblast Cultures , 1995, Journal of dental research.

[36]  L L Otis,et al.  Imaging of hard- and soft-tissue structure in the oral cavity by optical coherence tomography. , 1998, Applied optics.

[37]  J. F. Yang,et al.  Collagenase activity in oral submucous fibrosis. , 1992, Proceedings of the National Science Council, Republic of China. Part B, Life sciences.

[38]  Zhongping Chen,et al.  Optical coherence tomography of malignancy in hamster cheek pouches. , 2004, Journal of biomedical optics.

[39]  W. Harvey,et al.  An in-vitro comparison of human fibroblasts from normal and oral submucous fibrosis tissue. , 1987, Archives of oral biology.

[40]  F. Mehta,et al.  Prevalence of oral submucous fibrosis among 50,915 Indian villagers. , 1968, British Journal of Cancer.

[41]  C. Tsai,et al.  Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. , 1995, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[42]  T. Ling,et al.  Epidemiological survey of oral submucous fibrosis in Xiangtan City, Hunan Province, China. , 1997, Community dentistry and oral epidemiology.

[43]  W. Harvey,et al.  Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis , 1987, Experientia.