Relationship Between Serum and Cerebrospinal Fluid Oxidative Stress Index and the Infarct Volume in Patients with Acute Ischemic Stroke

Objective: The aim of this study was to investigate the relationship between the oxidative stress index (OSI) values in serum and cerebrospinal fluid (CSF) and the multidetector computed tomography (MCT) infarct volumes, in patients with ischemic stroke. Material and Methods: This study included 40 patients (22 females and 18 males) who were hospitalized at the Neurology clinic and who were monitored for ischemic stroke. Infarct volumes of the patients with ischemic stroke were measured with control MCT 48-72 hours later. Blood and CSF samples were collected from all patients after 48-72 hours. Total serum and CSF peroxide concentrations were detected with the FOX-2 method. Total antioxidant capacity in CSF and serum samples was measured with a kit containing ABTS [2-2’ -azinobis-(3-ethyl-benzothiazoline-6-sulphonic acid)]. Total peroxide value was divided by total antioxidant capacity value and OSI was determined. The relationship between serum and CSF oxidative stress index and infarction volumes was studied. Results: There was a significant corelation between average infarct volumes of all patients and both serum and CSF OSI average values in all patients. Conclusion: In conclusion, the finding of a relationship between oxidative stress and infarct volume of the cerebral ischemia might provide new insights into the pathogenesis of ischemic stroke as well as open new therapeutic possibilities. Therefore, we suggest that, OSI may be useful as a marker to determine the progress of the brain tissue damage.