Increased IL‐21 expression in chronic rhinosinusitis with nasalpolyps

IL‐21 is a key cytokine for regulating B cell immunity, which is involved in several inflammatory conditions. This study sought to define a role for IL‐21 in activated B lymphocytes and enhanced tissue eosinophilia in NP tissues during the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP).

[1]  Jianbo Shi,et al.  The antimicrobial protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is differentially modulated in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps. , 2014, The Journal of allergy and clinical immunology.

[2]  S. Tangye,et al.  The good, the bad and the ugly — TFH cells in human health and disease , 2013, Nature Reviews Immunology.

[3]  A. Peters,et al.  Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression. , 2013, The Journal of allergy and clinical immunology.

[4]  A. Kato,et al.  B-lymphocyte lineage cells and the respiratory system. , 2013, The Journal of allergy and clinical immunology.

[5]  C. Bachert,et al.  Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps , 2013, Allergy.

[6]  R. Liu,et al.  A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis , 2012, Arthritis Research & Therapy.

[7]  M. Holtzman Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens. , 2012, The Journal of clinical investigation.

[8]  Zheng Liu,et al.  Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy. , 2012, The Journal of allergy and clinical immunology.

[9]  H. Goossens,et al.  EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. , 2012, Rhinology.

[10]  J. Egen,et al.  IgE+ memory B cells and plasma cells generated through a germinal-center pathway , 2012, Nature Immunology.

[11]  A. Peters,et al.  Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps. , 2011, The Journal of allergy and clinical immunology.

[12]  C. Bachert,et al.  Pathogenesis of chronic rhinosinusitis: inflammation. , 2011, The Journal of allergy and clinical immunology.

[13]  C. Kallenberg,et al.  Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus , 2011, Arthritis research & therapy.

[14]  Guang-Yu Li,et al.  The Characterization of IL-17A Expression in Patients with Chronic Rhinosinusitis with Nasal Polyps , 2011, American journal of rhinology & allergy.

[15]  A. Peters,et al.  Pathophysiology of Chronic Rhinosinusitis with Nasal Polyp , 2011, American journal of rhinology & allergy.

[16]  D. Ye,et al.  Interleukin-21 as a potential therapeutic target for systemic lupus erythematosus , 2011, Molecular Biology Reports.

[17]  F. Pallone,et al.  Targeting interleukin-21 in inflammatory diseases , 2011, Expert opinion on therapeutic targets.

[18]  Xia Li,et al.  Targeting interleukin-21 in rheumatoid arthritis , 2011, Molecular Biology Reports.

[19]  M. Esiri,et al.  IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain , 2011, The American journal of pathology.

[20]  K. Van Steen,et al.  Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. , 2010, The Journal of allergy and clinical immunology.

[21]  W. Paul,et al.  Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells , 2010, Science.

[22]  K. Toellner,et al.  IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism , 2010, The Journal of experimental medicine.

[23]  M. Linterman,et al.  IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses , 2010, The Journal of experimental medicine.

[24]  Brigitta Stockinger,et al.  The functional plasticity of T cell subsets , 2009, Nature Reviews Immunology.

[25]  C. Mackay,et al.  A fundamental role for interleukin-21 in the generation of T follicular helper cells. , 2008, Immunity.

[26]  A. Peters,et al.  Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. , 2008, The Journal of allergy and clinical immunology.

[27]  I. Sanz,et al.  Phenotypic and functional heterogeneity of human memory B cells. , 2008, Seminars in immunology.

[28]  C. Bachert,et al.  Local immunoglobulin production in nasal polyposis is modulated by superantigens , 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[29]  W. Leonard,et al.  Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation , 2005, Nature Reviews Immunology.

[30]  S. Durham,et al.  Allergen Drives Class Switching to IgE in the Nasal Mucosa in Allergic Rhinitis1 , 2005, The Journal of Immunology.

[31]  R. Sindwani Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese , 2010 .

[32]  Stephen R Durham,et al.  Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma. , 2007, The Journal of allergy and clinical immunology.