Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2

[1]  T. Horvath,et al.  UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals , 2009, Nature.

[2]  T. Seyfried,et al.  Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet , 2008, Nutrition & metabolism.

[3]  J. Mackey,et al.  Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer , 2008, British Journal of Cancer.

[4]  N. Denko,et al.  Hypoxia, HIF1 and glucose metabolism in the solid tumour , 2008, Nature Reviews Cancer.

[5]  Gabriele Bergers,et al.  Modes of resistance to anti-angiogenic therapy , 2008, Nature Reviews Cancer.

[6]  M. Brand,et al.  On the role of uncoupling protein-2 in pancreatic beta cells. , 2008, Biochimica et biophysica acta.

[7]  Robert J. Gillies,et al.  Causes and Consequences of Increased Glucose Metabolism of Cancers , 2008, Journal of Nuclear Medicine.

[8]  C. Thompson,et al.  Uncoupling protein‐2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis‐derived pyruvate utilization , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  T. Kirkwood,et al.  Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence , 2007, PLoS biology.

[10]  A. Cassard-Doulcier,et al.  Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages. , 2007, The Biochemical journal.

[11]  Weiqin Jiang,et al.  2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. , 2005, Cancer research.

[12]  J. Wands,et al.  Expression of Uncoupling Protein-2 in Human Colon Cancer , 2004, Clinical Cancer Research.

[13]  E. Westman Is dietary carbohydrate essential for human nutrition? , 2002, The American journal of clinical nutrition.

[14]  S. Shirazi-Beechey,et al.  Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy , 2002, British Journal of Cancer.

[15]  P. Reynier,et al.  Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors. , 2001, The Journal of clinical endocrinology and metabolism.

[16]  D. Ricquier,et al.  The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. , 2000, The Biochemical journal.

[17]  G. Semenza,et al.  Oncogenic alterations of metabolism. , 1999, Trends in biochemical sciences.

[18]  R. Wolfe,et al.  Metabolic interactions between glucose and fatty acids in humans. , 1998, The American journal of clinical nutrition.

[19]  Kazutomo Inoue,et al.  Over-expression of facilitative glucose transporter genes in human cancer. , 1990, Biochemical and biophysical research communications.

[20]  R. A. Brennan,et al.  Reduction of weight loss and tumour size in a cachexia model by a high fat diet. , 1987, British Journal of Cancer.

[21]  K. Calman,et al.  Failure of systemic ketosis to control cachexia and the growth rate of the Walker 256 carcinosarcoma in rats. , 1985, British Journal of Cancer.

[22]  R. Denton,et al.  Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart. , 1970, The Biochemical journal.

[23]  G F Cahill,et al.  Brain metabolism during fasting. , 1967, The Journal of clinical investigation.

[24]  Mordecai Schwartz A biomathematical approach to clinical tumor growth , 1961, Cancer.

[25]  A. Goldin,et al.  Effects of glucose analogues (2-deoxy-D-glucose, 2-deoxy-D-galactose) on experimental tumors. , 1960, Journal of the National Cancer Institute.

[26]  O. Warburg [Origin of cancer cells]. , 1956, Oncologia.

[27]  J. Sparano,et al.  Carbohydrate restriction in patients with advanced cancer: A protocol to assess safety and feasibility with an accompanying hypothesis , 2008 .

[28]  C. Warden,et al.  Nutrition & Metabolism BioMed Central Review Uncoupling , 2006 .

[29]  L. Sidossis,et al.  Regulation of fatty acid oxidation in untrained vs. trained men during exercise. , 1998, American Journal of Physiology.