Antigen-receptor degeneracy and immunological paradigms.

This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.

[1]  I. Cohen,et al.  T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  I. Cohen.  Tending Adam's Garden: Evolving the Cognitive Immune Self , 2004 .

[3]  E. Sercarz,et al.  Self-reactive T cells and degeneracy of T cell recognition: evolving concepts-from sequence homology to shape mimicry and TCR flexibility. , 2001, Journal of autoimmunity.

[4]  I. Cohen,et al.  Immune information, self-organization and meaning. , 1998, International immunology.

[5]  S. Solomon,et al.  The importance of being discrete: life always wins on the surface. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[6]  A. Coutinho,et al.  From an Antigen‐Centered, Clonal Perspective of Immune Responses to an Organism‐Centered, Network Perspective of Autonomous Activity in a Self‐Referential Immune System , 1984, Immunological reviews.

[7]  I. Cohen,et al.  Discrimination and dialogue in the immune system. , 2000, Seminars in immunology.

[8]  F. Miedema,et al.  T cell dynamics in HIV-1 infection. , 1999, Advances in immunology.

[9]  C. Anderson,et al.  Danger: the view from the bottom of the cliff. , 2000, Seminars in immunology.

[10]  Z. Grossman,et al.  Autoreactivity, dynamic tuning and selectivity. , 2001, Current opinion in immunology.

[11]  Sorin Solomon,et al.  Complexity; a science at 30 , 2003 .

[12]  David Harel,et al.  The immune system as a reactive system: modeling T cell activation with statecharts , 2001, Proceedings IEEE Symposia on Human-Centric Computing Languages and Environments (Cat. No.01TH8587).

[13]  Martin Meier-Schellersheim,et al.  SIMMUNE, a tool for simulating and analyzing immune system behavior , 1999, ArXiv.

[14]  F. Burnet.  Self And Not-Self , 1969 .

[15]  Henri Atlan,et al.  Proliferation and competition in discrete biological systems , 2003, Bulletin of mathematical biology.

[16]  Sol Efroni,et al.  Simplicity belies a complex system: a response to the minimal model of immunity of Langman and Cohn. , 2002, Cellular immunology.

[17]  I. Cohen,et al.  The cognitive principle challenges clonal selection. , 1992, Immunology today.

[18]  Melvin Cohn,et al.  Does complexity belie a simple decision--on the Efroni and Cohen critique of the minimal model for a self-nonself discrimination. , 2003, Cellular immunology.

[19]  Sol Efroni,et al.  The heuristics of biologic theory: the case of self-nonself discrimination. , 2003, Cellular immunology.

[20]  P. Marrack,et al.  The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand , 1996, Cell.

[21]  Charles A. Janeway,et al.  Decoding the Patterns of Self and Nonself by the Innate Immune System , 2002, Science.