Epitope spreading: a mechanism for progression of autoimmune disease.

[1]  V. Tuohy,et al.  Regression and spreading of self-recognition during the development of autoimmune demyelinating disease. , 1999, Journal of autoimmunity.

[2]  V. Tuohy,et al.  Spontaneous Regression of Primary Autoreactivity during Chronic Progression of Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis , 1999, The Journal of experimental medicine.

[3]  R. Zinkernagel,et al.  Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes , 1998, The Journal of experimental medicine.

[4]  R. Maki,et al.  Role of interleukin 12 and costimulators in T cell anergy in vivo , 1997, The Journal of experimental medicine.

[5]  R. Kinkel,et al.  Diversity and plasticity of self recognition during the development of multiple sclerosis. , 1997, The Journal of clinical investigation.

[6]  L. Weiner,et al.  Defective post–thymic tolerance mechanisms during the chronic progressive stage of multiple sclerosis , 1996, Nature Medicine.

[7]  L Steinman,et al.  Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System , 1996, Cell.

[8]  C. Vandevyver,et al.  In vivo clonotypic regulation of human myelin basic protein-reactive T cells by T cell vaccination. , 1995, Journal of immunology.

[9]  S. Miller,et al.  Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis , 1995, The Journal of experimental medicine.

[10]  H. McFarland,et al.  Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals. , 1995, Journal of immunology.

[11]  M. Ejima,et al.  [Expression of Fas-antigen on T cells in multiple sclerosis]. , 1995, Rinsho shinkeigaku = Clinical neurology.

[12]  V. Tuohy,et al.  Sequence 104–117 of myelin proteolipid protein is a cryptic encephalitogenic T cell determinant for SJL/J mice , 1995, Journal of Neuroimmunology.

[13]  V. Tuohy,et al.  Self-determinants in autoimmune demyelinating disease: changes in T- cell response specificity. , 1994, Current opinion in immunology.

[14]  E. Sercarz,et al.  T cell determinant structure of myelin basic protein in B10.PL, SJL/J, and their F1S. , 1994, Journal of immunology.

[15]  W. I. McDonald,et al.  Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis , 1994, Neurology.

[16]  I. Cohen,et al.  Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis. , 1993, The Journal of clinical investigation.

[17]  A. Cross,et al.  Development of reactivity to new myelin antigens during chronic relapsing autoimmune demyelination. , 1993, Cellular immunology.

[18]  D. Miller,et al.  The significance of brain magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of multiple sclerosis. A 5-year follow-up study. , 1993, Brain : a journal of neurology.

[19]  E. Sercarz,et al.  Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen , 1992, Nature.

[20]  M. Jenkins,et al.  Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. , 1991, Journal of immunology.

[21]  A. Thompson,et al.  Multiple sclerosis and HLA: is the susceptibility gene really HLA-DR or -DQ? , 1991, Human immunology.

[22]  J. Trotter,et al.  T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis , 1991, Journal of Neuroimmunology.

[23]  A. Vandenbark,et al.  T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. , 1991, Science.

[24]  R. Sobel,et al.  Parental MHC molecule haplotype expression in (SJL/J x SWR)F1 mice with acute experimental allergic encephalomyelitis induced with two different synthetic peptides of myelin proteolipid protein. , 1991, Journal of immunology.

[25]  R. McCarron,et al.  Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis , 1990, Journal of Neuroimmunology.

[26]  R. Schwartz,et al.  A cell culture model for T lymphocyte clonal anergy. , 1990, Science.

[27]  Raine Cs.  Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis. , 1984 .

[28]  R. Kinkel,et al.  HLA-DP: a class II restriction molecule involved in epitope spreading during the development of multiple sclerosis. , 1998, Human immunology.

[29]  H. Erlich,et al.  Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles. , 1994, Human immunology.

[30]  D. McFarlin,et al.  Immunological aspects of demyelinating diseases. , 1992, Annual review of immunology.