Clinical effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: population-based longitudinal study

Objectives: to evaluate orthogeriatric and nurse-led fracture liaison service (FLS) models of post-hip fracture care in terms of impact on mortality (30 days and 1 year) and second hip fracture (2 years). Setting: Hospital Episode Statistics database linked to Office for National Statistics mortality records for 11 acute hospitals in a region of England. Population: patients aged over 60 years admitted for a primary hip fracture from 2003 to 2013. Methods: each hospital was analysed separately and acted as its own control in a before–after time-series design in which the appointment of an orthogeriatrician or set-up/expansion of an FLS was evaluated. Multivariable Cox regression (mortality) and competing risk survival models (second hip fracture) were used. Fixed effects meta-analysis was used to pool estimates of impact for interventions of the same type. Results: of 33,152 primary hip fracture patients, 1,288 sustained a second hip fracture within 2 years (age and sex standardised proportion of 4.2%). 3,033 primary hip fracture patients died within 30 days and 9,662 died within 1 year (age and sex standardised proportion of 9.5% and 29.8%, respectively). The estimated impact of introducing an orthogeriatrician on 30-day and 1-year mortality was hazard ratio (HR) = 0.73 (95% CI: 0.65–0.82) and HR = 0.81 (CI: 0.75–0.87), respectively. Following an FLS, these associations were as follows: HR = 0.80 (95% CI: 0.71–0.91) and HR = 0.84 (0.77–0.93). There was no significant impact on time to second hip fracture. Conclusions: the introduction and/or expansion of orthogeriatric and FLS models of post-hip fracture care has a beneficial effect on subsequent mortality. No evidence for a reduction in second hip fracture rate was found.

[1]  S. Sabharwal,et al.  Orthogeriatrics in the management of frail older patients with a fragility fracture , 2015, Osteoporosis International.

[2]  I. Harris,et al.  Orthogeriatric services associated with lower 30‐day mortality for older patients who undergo surgery for hip fracture , 2014, The Medical journal of Australia.

[3]  C. Cooper,et al.  Mortality in British hip fracture patients, 2000-2010: a population-based retrospective cohort study. , 2014, Bone.

[4]  H. Leufkens,et al.  The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000–2010 , 2014, Osteoporosis International.

[5]  C. Cooper,et al.  Describing variation in the delivery of secondary fracture prevention after hip fracture: an overview of 11 hospitals within one regional area in England , 2014, Osteoporosis International.

[6]  P. Geusens,et al.  Fracture liaison service: impact on subsequent nonvertebral fracture incidence and mortality. , 2014, The Journal of bone and joint surgery. American volume.

[7]  J. Eisman,et al.  Models of care for the secondary prevention of osteoporotic fractures: a systematic review and meta-analysis , 2013, Osteoporosis International.

[8]  A. Roddam,et al.  Persistence with osteoporosis medications among postmenopausal women in the UK General Practice Research Database , 2012, Menopause.

[9]  D. Beaton,et al.  Key outcomes are usually not reported in published fracture secondary prevention programs: results of a systematic review , 2014, Archives of Orthopaedic and Trauma Surgery.

[10]  P. Geusens,et al.  Impact of guideline implementation by a fracture nurse on subsequent fractures and mortality in patients presenting with non-vertebral fractures. , 2011, Injury.

[11]  T. Chesser,et al.  New NICE guideline to improve outcomes for hip fracture patients. , 2011, Injury.

[12]  C. Cooper,et al.  Breaking the fragility fracture cycle , 2011, Osteoporosis International.

[13]  S. Beard,et al.  Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost-effectiveness evaluation based on data collected over 8 years of service provision , 2011, Osteoporosis International.

[14]  S. Boonen,et al.  Coordinator-based systems for secondary prevention in fragility fracture patients , 2011, Osteoporosis International.

[15]  M. Seibel,et al.  Targeted intervention reduces refracture rates in patients with incident non-vertebral osteoporotic fractures: a 4-year prospective controlled study , 2011, Osteoporosis International.

[16]  G. Guyatt,et al.  Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis , 2010, Canadian Medical Association Journal.

[17]  M. Safford,et al.  Is withholding osteoporosis medication after fracture sometimes rational? A comparison of the risk for second fracture versus death. , 2010, Journal of the American Medical Directors Association.

[18]  C. Moran,et al.  Age-specific incidence of first and second fractures of the hip. , 2010, The Journal of bone and joint surgery. British volume.

[19]  C. Cooper,et al.  Excess mortality following hip fracture: a systematic epidemiological review , 2009, Osteoporosis International.

[20]  R. Dell,et al.  Osteoporosis disease management: the role of the orthopaedic surgeon. , 2008, The Journal of bone and joint surgery. American volume.

[21]  S. Boonen,et al.  Zoledronic acid and clinical fractures and mortality after hip fracture. , 2007, The New England journal of medicine.

[22]  S. Majumdar,et al.  Use of a case manager to improve osteoporosis treatment after hip fracture: results of a randomized controlled trial. , 2007, Archives of internal medicine.

[23]  P. Vestergaard,et al.  Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications , 2007, Osteoporosis International.

[24]  L. Giangregorio,et al.  Fragility fractures and the osteoporosis care gap: an international phenomenon. , 2006, Seminars in arthritis and rheumatism.

[25]  C. Moran,et al.  Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study , 2005, BMJ : British Medical Journal.

[26]  Stephen E Roberts,et al.  Time trends and demography of mortality after fractured neck of femur in an English population, 1968–98: database study , 2003, BMJ : British Medical Journal.

[27]  D. C. Bauer,et al.  Incidence and risk factors for a second hip fracture in elderly women. The Study of Osteoporotic Fractures , 2003, Osteoporosis International.

[28]  E. Marcantonio,et al.  Reducing Delirium After Hip Fracture: A Randomized Trial , 2001, Journal of the American Geriatrics Society.